Professor Dame Pamela J Shaw

DBE, MBBS, MD, FRCP, FMedSci, FAAN, FANA, FAAAS

Neuroscience, School of Medicine and Population Health

Director of the 91探花 Institute for Translational Neuroscience (SITraN)

Professor of Neurology

Director, NIHR Biomedical Research Centre Translational Neuroscience for Chronic Neurological Disorders

Director, 91探花 Care and Research Centre for Motor Neuron Disorders

Director, Cross-Faculty Flagship Neuroscience Institute

Honorary Consultant Neurologist, 91探花 Teaching Hospitals NHS Foundation Trust

Pamela Shaw
Profile picture of Pamela Shaw
pamela.shaw@sheffield.ac.uk
+44 114 222 2295
+44 114 226 1049 (Medical NHS Secretary: Helen Rains)
+44 114 222 2295 (Academic Administrator: Gillian Griffiths)

Full contact details

Professor Dame Pamela J Shaw
Neuroscience, School of Medicine and Population Health
91探花 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91探花
S10 2HQ
Profile

Pamela Shaw is an academic neurologist and a world-leading researcher in motor neuron disease (MND). She has held extensive leadership roles at local/national/international levels including: Director-91探花 Institute for Translational Neuroscience (SITraN) (2010-present); Director University of 91探花 Cross-Faculty Neuroscience Institute (2019-present); Pro-Vice Chancellor Faculty of Health (2016-2019). NIHR leadership roles include DeNDRoN Associate Director (2006-15);Yorkshire&Humber CRN Division 4 Lead (2014-16);Director-91探花 NIHR BRC (2017-present). Nationally she led the Association of British Neurologists (ABN) Clinical Research Academic Committee and served as panel member for MRC, Wellcome, Academy Medical Sciences, UKRI, Lister Institute, NIHR Senior Investigator awards. Internationally she is a founding/executive member of ENCALS and chaired the International Scientific Programme Committee for ALS/MND (2004-10).

She has systematically built scientific and clinical facilities and diverse, multidisciplinary teams to deliver effective translational research for neurodegeneration. She uses genetics and biological studies in pre-clinical model systems linked to human biosamples, to define novel pathways of disease, and to identify promising small molecule and gene-therapy targets, together with novel biomarkers.

Significant contributions from MND clinical research include: identification and introduction into clinical practice of riluzole; evaluation of further potential neuroprotective therapies in >22 clinical trials; demonstration that support with non-invasive ventilation (NIV) has a major positive impact on QOL and survival which changed management internationally.  She has contributed significantly to the genetic subclassification of MND including identification of changes in CHMP2B;TARDB;FUS;C9ORF72;TUBA4A;NEK1;Annexin A11;GLT8D1 genes, together with the associated clinical phenotype and molecular pathology. She has also demonstrated the value of offering routine genetic screening for MND patients.

Her team has generated a translational pipeline of potential neuroprotective therapies.  Using viral vectors (AAV9) to deliver neuroprotective cargoes to the CNS, she has demonstrated dramatic therapeutic effects in pre-clinical models of SOD1-MND and SMA. This work has underpinned successful experimental medicine trials.   Transcriptomic work has identified several pathways which can be modified therapeutically including the NRF2-anti-oxidant response and SRSF1, which are currently being developed towards MND clinical trials. 

She has authored >560 publications (H-index 116, Citations 48,225) and secured >拢140m in research funding. She has supervised and mentored the career development of >190 young scientists and clinicians, including 55 PhD students.  She has delivered >600 presentations at national/international venues including many plenary/keynote invited lectures.

Multiple awards recognising her translational research contributions include: NIHR Senior Investigator Award-2013-2021; DBE for Services to Neuroscience-2014; American Academy of Neurology Sheila Essey Award-2001;International ALS/MND Alliance Forbes Norris Award-2007;Royal College of Physicians Jean Hunter Award-2006/Croonian Lecture-2016; FMedSci-2007; Fellowship American Association for the Advancement of Science-2015;ABN Medallist-2019; Queen鈥檚 Anniversary Award to SITraN-2019; Singhal Award Lecture World Congress of Neurology 2021; Platinum Clinical Excellence Award-2013-present; British Neuroscience Research Excellence award 2022.

She has supported academic capacity development locally, building a department of >300 staff and graduate students since 2000 and nationally through DeNDroN and the ABN. She has mentored future research leaders through the NIHR Academy and the Academy of Medical Sciences.  As Pro-VC she led the Medical School Athena Swan Silver award and promoted the Faculty Equality-Diversity-Inclusion agenda appointing a Faculty EDI Director and introducing mandatory EDI staff training.   

Professor Shaw graduated in Medicine with 1st Class Honours from the University of Newcastle in 1979. She undertook her MRCP and Specialist Training in Neurology in Newcastle.

In 1988 she was awarded an MD with commendation for her work on the neurological complications of coronary bypass surgery. After an intermediate fellowship award from the Wellcome Trust, she was awarded a Wellcome Senior Fellowship in Clinical Science which she held from 1991 -2001.

In 1997 she was appointed Professor of Neurological Medicine at the University of Newcastle and in 2000 was appointed as Professor of Neurology at the University of 91探花.

As an undergraduate in Newcastle she was awarded the Stephen Scott; Gibb; Mary Gordon; Mona McNaughton and Phillipson Prizes/Scholarships and achieved distinction in all undergraduate examinations.

Research interests

Professor Shaw is a Clinician Scientist in Neurology, an emeritus NIHR Senior Investigator and formerly a Wellcome Senior Clinical Fellow. Supported by long-term programme funding from the Wellcome Trust, she has since 1991 led a major multidisciplinary programme of research investigating genetic, molecular and neurochemical factors underlying neurodegenerative disorders of the human motor system.

Her team use robust cellular and in vivo models of neurodegeneration and correlate key findings with disease related changes in the human nervous system. Significant research achievements include:

  1. Identification of cell specific features of motor neurons which underlie susceptibility to neurodegeneration.
  2. Understanding the cellular pathways of motor neuron injury in the presence of mutant SOD1 using a combination of cell biology, proteomics and gene expression profiling.
  3. Subclassification of motor neuron disease (MND) based on genetics and molecular pathology.
  4. Development of new small molecule and gene therapy candidate treatments for patients using staged screening programmes in cellular and other experimental model systems linked to human biosamples.
  5. Promoting the introduction of neuroprotective treatments for MND into trials and clinical practice e.g. riluzole, tofersen, aldesleukin.
  6. Establishing the role of non-invasive ventilation (NIV) in improving the quality of life and prolonging survival of MND patients.

Professor Shaw鈥檚 research is currently funded by the Medical Research Council, NIHR, LifeArc, the Motor Neurone Disease Association, the My Name鈥5 Doddie Foundation, Fight MND, the US Department of Defence, the European Union and biotechnology & pharmaceutical industry partners.

Current projects

Professor Shaw鈥檚 research is focused on 3 main goals:

  1. To understand the function of motor neurons in health and disease and to translate basic science findings into health benefits for patients with degenerative motor system disorders.
  2. To provide excellent clinical care for patients with motor system disorders, at all disease stages incorporating: multidisciplinary team working, evidence based standards of care for symptomatic management, and evaluation of new neuroprotective therapies.
  3. To foster excellent training for clinical and scientific junior staff with the aim of ensuring high standards of future care and linking new developments in medical science firmly to the needs of patients with neurological disorders.

Since 1983 she has supervised the research training of > 190 individuals from medicine and science including 55 PhD/MD students.

Professor Shaw is the Director of the NIHR 91探花 Biomedical Research Centre translating new potential treatments from SITraN research into early phase and experimental medicine clinical trials

Publications

Journal articles

  • Qiang Z, Barnett L, Bingham G, Han O, Walsh A, Conwill M, McDonough HE, McDermott CJ, Shaw PJ & Alix JJP (2025) . Journal of Neurology, 272(1). RIS download Bibtex download
  • Webster CP, Hall B, Crossley OM, Dauletalina D, King M, Lin Y-H, Castelli LM, Yang Z-L, Coldicott I, Kyrgiou-Balli E , Higginbottom A et al (2025) . Life Science Alliance, 8(2), e202402757-e202402757. RIS download Bibtex download
  • Harvey C, Nowak A, Zhang S, Moll T, Weimer AK, Barcons AM, Souza CDS, Ferraiuolo L, Kenna K, Zaitlen N , Caggiano C et al (2024) . RIS download Bibtex download
  • Rawlinson C, Gould RL, McDermott CJ, Thompson B, Weeks K, Gossage-Worrall R, Serfaty MA, Graham CD, McCracken L, White D , Howard RJ et al (2024) . The Cognitive Behaviour Therapist, 17. RIS download Bibtex download
  • Saez-Atienzar S, Souza CDS, Chia R, Beal SN, Lorenzini I, Huang R, Levy J, Burciu C, Ding J, Gibbs JR , Jones A et al (2024) . Cell Genomics, 100679-100679. RIS download Bibtex download
  • Burrows DJ, McGown A, Abduljabbar O, Castelli LM, Shaw PJ, Hautbergue GM & Ramesh TM (2024) . Annals of Neurology. RIS download Bibtex download
  • van den Berg LH, Rothstein JD, Shaw PJ, Babu S, Benatar M, Bucelli RC, Genge A, Glass JD, Hardiman O, Libri V , Mobach T et al (2024) . The Lancet Neurology. RIS download Bibtex download
  • Vrellaku B, Hassan IS, Howitt R, Webster CP, Harriss E, McBlane F, Betts C, Schettini J, Lion M, Mindur JE , Duerr M et al (2024) . Molecular Therapy. RIS download Bibtex download
  • Shaw PJ & Cooper-Knock J (2024) . Neurology, 103(2). RIS download Bibtex download
  • Au WH, Miller-Fleming L, Sanchez-Martinez A, Lee JAK, Twyning MJ, Prag HA, Raik L, Allen SP, Shaw PJ, Ferraiuolo L , Mortiboys H et al (2024) . Life Science Alliance, 7(9), e202402853-e202402853. RIS download Bibtex download
  • Marriott H, Spargo TP, Al Khleifat A, Andersen PM, Ba艧ak NA, Cooper鈥怟nock J, Corcia P, Couratier P, de Carvalho M, Drory V , Gotkine M et al (2024) . Annals of Clinical and Translational Neurology. RIS download Bibtex download
  • Ta艧 G, Westerdijk T, Postma E, van Rheenen W, Bakker MK, van Eijk KR, Kooyman M, Al Khleifat A, Iacoangeli A, Ticozzi N , Cooper-Knock J et al (2024) . Bioinformatics, 40(6). RIS download Bibtex download
  • Alarcan H, Bruno C, Emond P, Raoul C, Vourc'h P, Corcia P, Camu W, Veyrune J, Garlanda C, Locati M , Juntas鈥怣orales R et al (2024) . Annals of the New York Academy of Sciences. RIS download Bibtex download
  • Gould RL, McDermott CJ, Thompson BJ, Rawlinson CV, Bursnall M, Bradburn M, Kumar P, Turton EJ, White DA, Serfaty MA , Graham CD et al (2024) . The Lancet. RIS download Bibtex download
  • Arag贸n-Gonz谩lez A, Shaw AC, Kok JR, Roussel FS, Santos Souza CD, Granger SM, Vetter T, de Diego Y, Meyer KC, Beal SN , Shaw PJ et al (2024) . Fluids and Barriers of the CNS, 21(1). RIS download Bibtex download
  • Conwill MT, Alix JJP & Shaw PJ (2024) . Muscle & Nerve, 69(6), 733-734. RIS download Bibtex download
  • Alix JJP, Plesia M, Dudgeon AP, Kendall CA, Hewamadduma C, Hadjivassiliou M, Gorman GS, Taylor RW, McDermott CJ, Shaw PJ , Mead RJ et al (2024) . The Analyst. RIS download Bibtex download
  • Harvey C, Weinreich M, Lee JAK, Shaw AC, Ferraiuolo L, Mortiboys H, Zhang S, Hop PJ, Zwamborn RAJ, van Eijk K , Julian TH et al (2024) . Heliyon, 10(3), e24975-e24975. RIS download Bibtex download
  • Evans LJ, O鈥橞rien D & Shaw PJ (2024) . RIS download Bibtex download
  • Bell SM, Wareing H, Hamshaw A, De S, New E, Shaw P, De Marco M, Venneri A, Blackburn DJ, Ferraiuolo L & Mortiboys H (2023) . Alzheimer's & Dementia, 19(S13). RIS download Bibtex download
  • Lombardo FL, Spila Alegiani S, Mayer F, Cipriani M, Lo Giudice M, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH , Hardiman O et al (2023) . Trials, 24(1). RIS download Bibtex download
  • Richardson PJ, Smith DP, de Giorgio A, Snetkov X, Almond-Thynne J, Cronin S, Mead RJ, McDermott CJ & Shaw PJ (2023) . Translational Neurodegeneration, 12(1). RIS download Bibtex download
  • Gould RL, Rawlinson C, Thompson B, Weeks K, Gossage-Worrall R, Cantrill H, Serfaty MA, Graham CD, McCracken LM, White D , Howard RJ et al (2023) . Pilot and Feasibility Studies, 9. RIS download Bibtex download
  • Chen Z, Reynolds RH, Pardi帽as AF, Gagliano Taliun SA, van Rheenen W, Lin K, Shatunov A, Gustavsson EK, Fogh I, Jones AR , Robberecht W et al (2023) . Neurobiology of Disease, 180, 106082-106082. RIS download Bibtex download
  • Adey BN, Cooper-Knock J, Al Khleifat A, Fogh I, van Damme P, Corcia P, Couratier P, Hardiman O, McLaughlin R, Gotkine M , Drory V et al (2023) . Frontiers in Cellular Neuroscience, 17. RIS download Bibtex download
  • Castelli LM, Lin Y-H, Sanchez-Martinez A, G眉l A, Mohd Imran K, Higginbottom A, Upadhyay SK, M谩rkus NM, Rua Martins R, Cooper-Knock J , Montmasson C et al (2023) . Science Translational Medicine, 15(685). RIS download Bibtex download
  • Gandhi R, Selvarajah D, Sloan G, Greig M, Wilkinson ID, Shaw PJ, Griffiths P & Tesfaye S (2023) . Frontiers in Pain Research, 3. RIS download Bibtex download
  • Yildiz O, Schroth J, Tree T, Turner MR, Shaw PJ, Henson SM & Malaspina A (2023) . Neurology - Neuroimmunology Neuroinflammation, 10(1), e200042-e200042. RIS download Bibtex download
  • Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JNG, dos Santos Souza C, Zhang S , Castelli L et al (2023) . Life Science Alliance, 6(1), e202201449-e202201449. RIS download Bibtex download
  • Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-脕lvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) . Frontiers in Cellular Neuroscience, 16. RIS download Bibtex download
  • Al Khleifat A, Iacoangeli A, Jones AR, van Vugt JJFA, Moisse M, Shatunov A, Zwamborn RAJ, van der Spek RAA, Cooper-Knock J, Topp S , van Rheenen W et al (2022) . Frontiers in Cellular Neuroscience, 16. RIS download Bibtex download
  • Arag贸n-Gonz谩lez A, Shaw PJ & Ferraiuolo L (2022) . International Journal of Molecular Sciences, 23(23). RIS download Bibtex download
  • Opie-Martin S, Iacoangeli A, Topp SD, Abel O, Mayl K, Mehta PR, Shatunov A, Fogh I, Bowles H, Limbachiya N , Spargo TP et al (2022) . Nature Communications, 13(1). RIS download Bibtex download
  • Mehta PR, Iacoangeli A, Opie-Martin S, van Vugt JJFA, Al Khleifat A, Bredin A, Ossher L, Andersen PM, Hardiman O, Mehta AR , Fratta P et al (2022) . Brain, 145(12), 4440-4447. RIS download Bibtex download
  • Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chi貌 A, Van Damme P, Ludolph AC, Glass JD , Andrews JA et al (2022) . New England Journal of Medicine, 387(12), 1099-1110. RIS download Bibtex download
  • Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ & Sobue G (2022) . The Lancet. RIS download Bibtex download
  • Sassani M, Alix J, Baster K, Cercignani M, Shaw P & Jenkins T (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.136-e2.136. RIS download Bibtex download
  • Chapman L, Shepheard S, Verber N, Turner M, Malaspina A, Rogers M-L & Shaw P (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.130-e2.130. RIS download Bibtex download
  • Shaw P, Miller T, Cudkowicz M, Genge A, Sobue G, Nestorov I, Graham D-I, Fanning L, Fradette S & McNeill M (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.208-e2.208. RIS download Bibtex download
  • Dennys C, Baggio C, Rodrigo R, Roussel F, Kulinich A, Heintzman S, Fox A, Kolb SJ, Shaw PJ, Ethell IM , Pellecchia M et al (2022) . iScience, 104877-104877. RIS download Bibtex download
  • Cooper鈥怟nock J, Julian TH, Feneberg E, Highley JR, Sidra M, Turner MR, Talbot K, Ansorge O, Allen SP, Moll T , Shelkovnikova T et al (2022) . Brain Pathology. RIS download Bibtex download
  • Alix JJP, Plesia M, Hool SA, Coldicott I, Kendall CA, Shaw PJ, Mead RJ & Day JC (2022) . Muscle and Nerve. RIS download Bibtex download
  • Franklin J, Cooper-Knock J, Baheerathan A, Moll T, Heverin M, Hardiman O, Mannikko R, Shaw P & Hanna M (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(6), A13.2-A13. RIS download Bibtex download
  • Price K, Mellor J, Mcnamara M, Hewamadduma C, Shaw P, Derott CM & Hadjivassiliou M (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(6), A10.1-A10. RIS download Bibtex download
  • Schooling CN, Healey TJ, McDonough HE, French SJ, McDermott CJ, Shaw PJ, Kadirkamanathan V & Alix JJP (2022) . Clinical Neurophysiology, 139, 69-75. RIS download Bibtex download
  • Alix J, Plesia M, Lloyd GR, Dudgeon A, Kendall CA, Hewamadduma C, Hadjivassiliou M, McDermott C, Gorman G, Taylor R , Shaw PJ et al (2022) . Analyst. RIS download Bibtex download
  • Marrone L, Marchi PM, Webster CP, Marroccella R, Coldicott I, Reynolds S, Alves-Cruzeiro J, Yang Z-L, Higginbottom A, Khundadze M , Shaw PJ et al (2022) . Human Molecular Genetics. RIS download Bibtex download
  • Gomes C, Sequeira C, Likhite S, Dennys CN, Kolb SJ, Shaw PJ, Vaz AR, Kaspar BK, Meyer K & Brites D (2022) . Cells, 11(7). RIS download Bibtex download
  • Eitan C, Siany A, Barkan E, Olender T, van Eijk KR, Moisse M, Farhan SMK, Danino YM, Yanowski E, Marmor-Kollet H , Rivkin N et al (2022) . Nature Neuroscience, 25(4), 433-445. RIS download Bibtex download
  • Boddy S, Islam M, Moll T, Kurz J, Burrows D, McGown A, Bhargava A, Julian TH, Harvey C, Marshall JNG , Hall BPC et al (2022) . Brain Communications, 4(2). RIS download Bibtex download
  • Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J , Tazelaar GHP et al (2022) . Science Translational Medicine, 14(633). RIS download Bibtex download
  • Thompson AG, Gray E, Verber N, Bobeva Y, Lombardi V, Shepheard SR, Yildiz O, Feneberg E, Farrimond L, Dharmadasa T , Gray P et al (2022) . Brain Communications, 4(1). RIS download Bibtex download
  • van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P , Shireby G et al (2022) . Nature Genetics, 54(3), 361-361. RIS download Bibtex download
  • Al Khleifat A, Iacoangeli A, van Vugt JJFA, Bowles H, Moisse M, Zwamborn RAJ, van der Spek RAA, Shatunov A, Cooper-Knock J, Topp S , Byrne R et al (2022) . npj Genomic Medicine, 7(1). RIS download Bibtex download
  • Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS , Ning K et al (2022) . Neuron. RIS download Bibtex download
  • 艩kori膰-Milosavljevi膰 D, Tadros R, Bosada FM, Tessadori F, van Weerd JH, Woudstra OI, Tjong FVY, Lahrouchi N, Bajolle F, Cordell HJ , Agopian AJ et al (2022) . Circulation Research, 130(2), 166-180. RIS download Bibtex download
  • Julian TH, Boddy S, Islam M, Kurz J, Whittaker KJ, Moll T, Harvey C, Zhang S, Snyder MP, McDermott C , Cooper-Knock J et al (2022) . Brain, 145(3), 832-842. RIS download Bibtex download
  • Alix JJP, Plesia M, Lloyd GR, Dudgeon AP, Kendall CA, McDermott CJ, Gorman GS, Taylor RW, Shaw PJ & Day JC (2022) . Journal of Raman Spectroscopy, 53(2), 172-181. RIS download Bibtex download
  • Chan Y, Alix JJP, Neuwirth C, Barkhaus PE, Castro Tech J, Jenkins TM, McDermott CJ, Shaw PJ, Carvalho M, Nandedkar S , St氓lberg E et al (2022) . Muscle & Nerve, 65(2), 203-210. RIS download Bibtex download
  • Anton A, Mead RJ, Shaw PJ, Edden RAE, Bigley J, Jenkins TM, Wild JM, Hoggard N & Wilkinson ID (2022) . Journal of Magnetic Resonance Imaging, 55(2), 435-442. RIS download Bibtex download
  • Benson BC, Shaw PJ, Azzouz M, Highley JR & Hautbergue GM (2021) . Frontiers in Neuroscience, 15. RIS download Bibtex download
  • Moll T, Marshall JNG, Soni N, Zhang S, Cooper-Knock J & Shaw PJ (2021) . Essays in Biochemistry, 65(7), 999-1011. RIS download Bibtex download
  • van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P , Shireby G et al (2021) . Nature Genetics, 53(12), 1636-1648. RIS download Bibtex download
  • Schooling CN, Healey TJ, McDonough HE, French SJ, McDermott CJ, Shaw PJ, Kadirkamanathan V & Alix JJP (2021) . Physiological Measurement, 42(10). RIS download Bibtex download
  • Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR , Cookson MR et al (2021) . JAMA Neurology, 78(10), 1236-1248. RIS download Bibtex download
  • Shaw P (2021) . Journal of the Neurological Sciences, 429, 117636-117636. RIS download Bibtex download
  • Sassani M, Alix J, Mcdermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T (2021) . Journal of the Neurological Sciences, 429, 119412-119412. RIS download Bibtex download
  • van Eijk RPA, Nikolakopoulos S, Roes KCB, Kendall L, Han SS, Lavrov A, Epstein N, Kliest T, de Jongh AD, Westeneng H-J , Al-Chalabi A et al (2021) . Neurology, 97(11), 528-536. RIS download Bibtex download
  • Gerou M, Hall B, Woof R, Allsop J, Kolb SJ, Meyer K, Shaw PJ & Allen SP (2021) . Neurobiology of Aging, 105, 64-77. RIS download Bibtex download
  • Jim茅nez-Villegas J, Ferraiuolo L, Mead RJ, Shaw PJ, Cuadrado A & Rojo AI (2021) . Free Radical Biology and Medicine, 173, 125-141. RIS download Bibtex download
  • Watkins JA, Alix JJP, Shaw PJ & Mead RJ (2021) . Scientific Reports, 11(1). RIS download Bibtex download
  • Giovannelli I, Bayatti N, Brown A, Wang D, Mickunas M, Camu W, Veyrune J-L, Payan C, Garlanda C, Locati M , Juntas-Morales R et al (2021) . Brain Communications, 3(3). RIS download Bibtex download
  • Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Lin Y-H, Myszczynska MA, Heath PR, Livesey MR, Ning K , Azzouz M et al (2021) . Molecular Neurodegeneration, 16(1). RIS download Bibtex download
  • Dajti I, Valenzuela JI, Boccalatte LA, Gemelli NA, Smith DE, Dudi-Venkata NN, Kroon HM, Sammour T, Roberts M, Mitchell D , Lah K et al (2021) . British Journal of Surgery, 108(11), 1274-1292. RIS download Bibtex download
  • Ciervo Y, Gatto N, Allen C, Grierson A, Ferraiuolo L, Mead RJ & Shaw PJ (2021) . Molecular Therapy 鈥 Methods & Clinical Development, 21, 413-433. RIS download Bibtex download
  • Pham TK, Buczek WA, Mead RJ, Shaw PJ & Collins MO (2021) . Frontiers in Molecular Neuroscience, 14. RIS download Bibtex download
  • Julian TH, Glascow N, Barry ADF, Moll T, Harvey C, Klimentidis YC, Newell M, Zhang S, Snyder MP, Cooper-Knock J & Shaw PJ (2021) . EBioMedicine, 68. RIS download Bibtex download
  • Plesia M, Stevens OA, Lloyd GR, Kendall CA, Coldicott I, Kennerley AJ, Miller G, Shaw PJ, Mead RJ, Day JCC & Alix JJP (2021) . ACS Chemical Neuroscience, 12(10), 1768-1776. RIS download Bibtex download
  • Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS , Wallace L et al (2021) . Genome Biology, 22. RIS download Bibtex download
  • Shepheard SR, Parker MD, Cooper-Knock J, Verber NS, Tuddenham L, Heath P, Beauchamp N, Place E, Sollars ESA, Turner MR , Malaspina A et al (2021) . Journal of Neurology, Neurosurgery & Psychiatry, 92(5), 510-518. RIS download Bibtex download
  • Appleby鈥怣allinder C, Schaber E, Kirby J, Shaw PJ, Cooper鈥怟nock J, Heath PR & Highley JR (2021) . Neuropathology and Applied Neurobiology, 47(1), 61-72. RIS download Bibtex download
  • Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin JP, Allen S, Nezhad HG, Iacoangeli A, Yacovzada NY, Eitan C , Hornstein E et al (2021) . Cell Reports, 34(5), 108730-108730. RIS download Bibtex download
  • Boddy SL, Giovannelli I, Sassani M, Cooper-Knock J, Snyder MP, Segal E, Elinav E, Barker LA, Shaw PJ & McDermott CJ (2021) . BMC Medicine, 19(1). RIS download Bibtex download
  • Gatto N, Dos Santos Souza C, Shaw AC, Bell SM, Myszczynska MA, Powers S, Meyer K, Castelli LM, Karyka E, Mortiboys H , Azzouz M et al (2021) . Aging Cell, 20(1). RIS download Bibtex download
  • Moisse M, Zwamborn RAJ, Vugt J, Spek R, Rheenen W, Kenna B, Van Eijk K, Kenna K, Corcia P, Couratier P , Vourc'h P et al (2021) . Annals of Neurology, 89(4), 686-697. RIS download Bibtex download
  • Sassani M, Alix J, McDermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T (2021) . Brain, 143(12), 3603-3618. RIS download Bibtex download
  • Bell SM, Barnes K, De Marco M, Shaw PJ, Ferraiuolo L, Blackburn DJ, Venneri A & Mortiboys H (2021) . Biomedicines, 9(1). RIS download Bibtex download
  • Bury JJ, Chambers A, Heath PR, Ince PG, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB (2021) . Acta Neuropathologica Communications, 9(1). RIS download Bibtex download
  • Dewan R, Chia R, Ding J, Hickman RA, Stein TD, Abramzon Y, Ahmed S, Sabir MS, Portley MK, Tucci A , Ib谩帽ez K et al (2021) . Neuron, 109(3), 448-460.e4. RIS download Bibtex download
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  • Majounie E, Renton AE, Mok K, Dopper EGP, Waite A, Rollinson S, Chi貌 A, Restagno G, Nicolaou N, Simon-Sanchez J , van Swieten JC et al (2012) . The Lancet Neurology, 11(4), 323-330. RIS download Bibtex download
  • Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chi貌 A, Restagno G, Nicolaou N, Simon-Sanchez J , van Swieten JC et al (2012) Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. The Lancet Neurology. RIS download Bibtex download
  • Bourke SC, O'Neill CL, Williams TL, Peel ET, Gibson GJ, McDermott CJ & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, 83(4), 368-369. RIS download Bibtex download
  • Hughes P, Seymour L, Hollinger H, Evans J, McDermott C & Shaw P (2012) . BMJ Supportive & Palliative Care, 2(Suppl 1), A102.3-A103. RIS download Bibtex download
  • Cooper-Knock J, Hewitt C, Highley JR, Brockington A, Milano A, Man S, Martindale J, Hartley J, Walsh T, Gelsthorpe C , Baxter L et al (2012) . Brain, 135(3), 751-764. RIS download Bibtex download
  • Harwood CA, McDermott CJ & Shaw PJ (2012) . Medicine, 40(10), 540-545. RIS download Bibtex download
  • Mok K, Traynor BJ, Schymick J, Tienari PJ, Laaksovirta H, Peuralinna T, Myllykangas L, Chi貌 A, Shatunov A, Boeve BF , Boxer AL et al (2012) . Neurobiology of Aging, 33(1), 209.e3-209.e8. RIS download Bibtex download
  • O'Neill CL, Williams TL, Peel ET, McDermott CJ, Shaw PJ, Gibson GJ & Bourke SC (2012) . Journal of Neurology, Neurosurgery & Psychiatry, 83(4), 371-376. RIS download Bibtex download
  • Gibbons CJ, Mills RJ, Thornton EW, Ealing J, Mitchell JD, Shaw PJ, Talbot K, Tennant A & Young CA (2011) . Health and Quality of Life Outcomes, 9(1). RIS download Bibtex download
  • Ince PG, Highley JR, Kirby J, Wharton SB, Takahashi H, Strong MJ & Shaw PJ (2011) . Acta Neuropathologica, 122(6), 657-671. RIS download Bibtex download
  • Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) . Neuroscience Letters, 505(1), 25-30. RIS download Bibtex download
  • Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort. Neuroscience Letters. RIS download Bibtex download
  • Ferraiuolo L, Kirby J, Grierson AJ, Sendtner M & Shaw PJ (2011) . Nat Rev Neurol, 7(11), 616-630. RIS download Bibtex download
  • Ismail A, Sharrack B, Constantinescu C, McDermott C & Shaw P (2011) Multiple sclerosis and amyotrophic lateral sclerosis - what is the link? A case series of six patients. MULTIPLE SCLEROSIS JOURNAL, 17, S472-S472. RIS download Bibtex download
  • Ning K, Drepper C, Valori CF, Wyles M, Ismail A, Higginbottom A, Herrmann T, Shaw PJ, Sendtner M & Azzouz M (2011) PTEN signalling in motor neuron disease (ALS & SMA). HUMAN GENE THERAPY, 22(10), A64-A64. RIS download Bibtex download
  • Nanou A, Higginbottom A, Wyles M, Ning K, Shaw P & Azzouz M (2011) Gene therapy approaches to evaluate neuroprotection in experimental models of Amyotrophic Lateral Sclerosis. HUMAN GENE THERAPY, 22(10), A64-A64. RIS download Bibtex download
  • Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE , Brayne C et al (2011) . Neurobiology of Aging, 32(10), 1795-1807. RIS download Bibtex download
  • Sargsyan SA, Blackburn DJ, Barber SC, Grosskreutz J, De Vos KJ, Monk PN & Shaw PJ (2011) . BMC Neuroscience, 12(1). RIS download Bibtex download
  • Mok K, Traynor BJ, Schymick J, Tienari PJ, Laaksovirta H, Peuralinna T, Myllykangas L, Chi貌 A, Shatunov A, Boeve BF , Boxer AL et al (2011) The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Aging. RIS download Bibtex download
  • Rafiq M, Sharrack N, Shaw PJ & Hadjivassiliou M (2011) . Practical Neurology, 11(5), 296-300. RIS download Bibtex download
  • Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J & Shaw PJ (2011) . Brain, 134(9), 2627-2641. RIS download Bibtex download
  • Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) . PLoS ONE, 6(8). RIS download Bibtex download
  • O'Neill CL, Williams TL, Peel ET, McDermott CJ, Shaw PJ, John G & Bourke SC (2011) Non-invasive ventilation in motor neuron disease: An update of current UK practice. Journal of Neurology, Neurosurgery and Psychiatry. RIS download Bibtex download
  • Simpson J, Ince P, Heath P, Raman R, Garwood C, Shaw P, Gelstorpe C, Baxter L, Forster G, Fiona M , Savva G et al (2011) . Alzheimer's & Dementia, 7(4S_Part_16). RIS download Bibtex download
  • Duffy LM, Chapman AL, Shaw PJ & Grierson AJ (2011) . Neuropathology and Applied Neurobiology, 37(4), 336-352. RIS download Bibtex download
  • Cooper-Knock J, Ahmedzai SH & Shaw P (2011) . Amyotrophic Lateral Sclerosis, 12(6), 464-465. RIS download Bibtex download
  • Barber SC, Wood-Allum CA, Sargsyan SA, Walsh T, Cox LE, Monk PN & Shaw PJ (2011) . Amyotrophic Lateral Sclerosis, 12(4), 257-263. RIS download Bibtex download
  • Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo S-W, Valori CF, Cox L, Sharrack B, Wharton SB , Ince PG et al (2011) . Brain, 134(2), 506-517. RIS download Bibtex download
  • Shaw PJ, Otto M, Bowser R, Turner M, Berry J, Brettschneider J, Connor J, Costa J, Cudkowicz M & Glass J (2011) . Amyotrophic Lateral Sclerosis. RIS download Bibtex download
  • Al-Chalabi A, Shaw PJ, Young CA, Morrison KE, Murphy C, Thornhill M, Kelly J, Steen IN & Leigh PN (2011) . BMC Neurology, 11. RIS download Bibtex download
  • Shaw PJ, Gibbons CJ, Mills RJ, Thornton EW, Ealing J, Mitchell JD, Talbot K, Tennant A & Young CA (2011) . Health and Quality of Life Outcomes. RIS download Bibtex download

Chapters

  • Shaw PJ & Kirby J (2024) INTERNATIONAL REVIEW OF NEUROBIOLOGY Motor Neurone Disease Preface, MOTOR NEURONE DISEASE (pp. XIX-XX). RIS download Bibtex download
  • Shaw PJ & Kirby J (2024) , International Review of Neurobiology (pp. xix-xx). Elsevier RIS download Bibtex download
  • Verber N & Shaw PJ (2021) , Aminoff's Neurology and General Medicine (pp. 285-302). Elsevier RIS download Bibtex download
  • Chandran JS, Scarrott JM, Shaw P & Azzouz M (2017) Gene Therapy in the Nervous System: Failures and Successes In El-Khamisy S (Ed.), Personalised Medicine Lessons from Neurodegeneration to Cancer Springer RIS download Bibtex download
  • Allen C, Shaw PJ & Ferraiuolo L (2017) In El-Khamisy (Ed.), Personalised Medicine RIS download Bibtex download
  • Chandran JS, Scarrott JM, Shaw PJ & Azzouz M (2017) , Advances in Experimental Medicine and Biology (pp. 241-257). Springer International Publishing RIS download Bibtex download
  • Hardiman O, Kelly JA, Bak TH, Elamin M, Mihaila DL, Shaw PJ, Mitsumoto H & Shefner JM (2016) , Neurodegenerative Disorders (pp. 289-303). Springer International Publishing RIS download Bibtex download
  • Abrams GM, Albers GW, Alix JJP, Aminoff MJ, Bharucha AE, Batla A, Benson CM, Betjemann JP, Brosch JR, Camilleri M , Chen R et al (2014) , Aminoff's Neurology and General Medicine (pp. vii-xii). Elsevier RIS download Bibtex download
  • Abrams CS, Accurso FJ, Afdhal NH, Akin C, Aksamit AJ, Al-Awqati Q, Allos BM, Altshuler D, Aminoff MJ, Anderson JL , Anderson KE et al (2012) , Goldman's Cecil Medicine (pp. ix-xxx). Elsevier RIS download Bibtex download
  • Shaw PJ (2012) , Goldman's Cecil Medicine (pp. 2343-2347). Elsevier RIS download Bibtex download
  • Shaw PA & Bryant RG (2011) (pp. 373-401). Wiley RIS download Bibtex download
  • Shaw PJ, Cooper-Knock J, Bury JJ, Ferraiuolo L, Goodall EF & Kirby J (2011) Gene Expression Profiling and its Application in Amyotrophic Lateral Sclerosis InTech Open Access RIS download Bibtex download
  • Shaw PJ & Wood-Allum C (2011) The Neurology of Thyroid Disease In Aminoff M (Ed.), Neurology of Systemic Disease RIS download Bibtex download

Conference proceedings papers

  • Hartopp N, Thoma A, Mossman E, Ellis L, Hughes R, Bhosale G, Gandini A, Pristera A, Doe C, Allen S , Ferraiuolo L et al (2024) . I: Experimental therapeutics 鈥 preclinical (pp A152.1-A152) RIS download Bibtex download
  • Ryan C, Shaw P & Shorey P (2023) . Posters RIS download Bibtex download
  • Miller TM, Cudkowicz M, Genge A, Shaw PJ, Sobue G, Fanning L, Gambino G, Garafalo S, Nestorov I, Graham D , Inra J et al (2023) Two-Year Results from the Open-Label Extension of VALOR: Tofersen in Adults with SOD1-ALS. MUSCLE & NERVE, Vol. 68 (pp S1-S2) RIS download Bibtex download
  • Milanese M, Provenzano F, Balbi M, Giunti D, Nyberg S, Parodi B, Bacchetti F, Torazza C, Bonifacino T, Usai C , de Rosbo NK et al (2023) In-vitro and in-vivo evidence supporting the therapeutic effect of extracellular vesicles derived from mesenchymal stem cells in amyotrophic lateral sclerosis. GLIA, Vol. 71 (pp E280-E281) RIS download Bibtex download
  • Bell S, De Marco M, Barnes K, Shaw P, Ferraiuolo L, Blackburn D, Mortiboys H & Venneri A (2020) Do deficits in Mitochondrial Spare Respiratory Capacity contribute to Neuropsychological changes seen in Alzheimer's disease?. NEUROLOGY, Vol. 94(15) RIS download Bibtex download
  • Allen SP, Hall B, Castelli L, Francis L, Woof R, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Webster CP , De Vos K et al (2018) . Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1859 (pp e23-e23) RIS download Bibtex download
  • Hewamadduma CA, Omalley R, Robinson M, Beauchamp N, Rogers T, Martindale J, Mcdermott C, Shaw P, Hoggard N & Hadjivassiliou M (2017) . Journal of the Neurological Sciences, Vol. 381 (pp 304-305) RIS download Bibtex download
  • Jenkins T, Alix J, Rao G, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J, McDermott C, Wilkinson I & Shaw P (2017) . Journal of the Neurological Sciences, Vol. 381 (pp 102-102) RIS download Bibtex download
  • (2016) . The Journal of Pathology, Vol. 240 (pp S1-S48) RIS download Bibtex download
  • Iannitti T, Scarrot JM, Coldicott IRP, Kaspar BK, Ferraiuolo L, Shaw PJ & Azzouz M (2016) Gene Therapy for Familial ALS Using AAV9 Mediated Silencing of Mutant SOD1. HUMAN GENE THERAPY, Vol. 27(7) (pp A12-A12) RIS download Bibtex download
  • Herranz-Martin S, Lewis KE, Coldicott I, Chandran JS, Lukashchuk V, Iannitti T, Shaw PJ & Azzouz M (2016) Experimental modelling of ALS by AAV-mediated in vivo modulation of the C9ORF72 gene. HUMAN GENE THERAPY, Vol. 27(7) (pp A16-A16) RIS download Bibtex download
  • Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2016) . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42(S1) (pp 28-28), 2 March 2016 - 4 March 2016. RIS download Bibtex download
  • Rafiq M, Proctor A, McDermott C & Shaw P (2015) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86(11) (pp e4.54-e4) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) . Journal of the Neurological Sciences, Vol. 357 (pp e49-e49) RIS download Bibtex download
  • Rafiq M, Lee E, Bradburn M, McDermott C & Shaw P (2015) Elevated creatine kinase is associated with a better prognosis in patients with amyotrophic lateral sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 22 (pp 741-741) RIS download Bibtex download
  • Rafiq M, Bradburn M, McDermott C & Shaw P (2015) Effects of cough augmentation on pulmonary morbidity, survival, and quality of life in patients with amyotrophic lateral sclerosis in respiratory failure: a randomised trial. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 22 (pp 244-244) RIS download Bibtex download
  • Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2015) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 26-27) RIS download Bibtex download
  • Beer A, Cooper-Knock J, Higginbottom A, Robin Highley J, Wharton SP, Milano A, Jones A, Al-Chalabi A, Kirby J & Shaw PJ (2014) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4) RIS download Bibtex download
  • Rafiq MK, Bradburn M, Proctor A, Billings C, Bianchi S, McDermott C & Shaw P (2014) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.93-e4) RIS download Bibtex download
  • Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32) RIS download Bibtex download
  • Rafiq M, Lee E, Bradburn M, McDermott C & Shaw P (2013) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 84(11) (pp e2.135-e2) RIS download Bibtex download
  • Binny C, Karyka E, Ning K, Bennett E, Ince P, Shaw P & Azzouz M (2013) Efficient scAAV9-mediated delivery of SMN to motor neurons in neonatal and juvenile mice. HUMAN GENE THERAPY, Vol. 24(5) (pp A38-A38) RIS download Bibtex download
  • Little D, Valori C, Wyles M, Shaw P, Azzouz M & Ning K (2013) Systemic delivery of scAAV9 expressing PTEN siRNA prolongs survival in a model of spinal muscular atrophy. HUMAN GENE THERAPY, Vol. 24(5) (pp A27-A27) RIS download Bibtex download
  • Highley JR, Cooper-Knock J, Frolov A, Charlesworth G, Kirby J, Wharton SB, Ince PG, Shaw PJ, Wood N & Bandman O (2013) A pathological basis for the association of parkinsonism and amyotrophic lateral sclerosis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 51-51) RIS download Bibtex download
  • Cooper-Knock J, Highley JR, Hartley J, Milano A, Sawcer S, Compston A, Frolov A, Charlesworth G, Wood N, Bandmann O , McDermott CJ et al (2013) . The Lancet, Vol. 381 (pp S32-S32) RIS download Bibtex download
  • Woollacott I, Shatunov A, Jones A, Morrison KE, Leigh PN, Shaw PJ, Shaw CE & Al-Chalabi A (2013) . The Lancet, Vol. 381 (pp S116-S116) RIS download Bibtex download
  • Rafiq M, Proctor AR, McDermott CJ & Shaw P (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A32.3-A33) RIS download Bibtex download
  • Al-Chalabi A, Shaw P, Kelly J, Morrison K, Murphy C, Thornhill M, Steen N & Leigh PN (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A31.3-A31) RIS download Bibtex download
  • Gibbons CJ, Cousins R, Pomeroy IM, Ando H, Al-Chalabi A, Chataway J, Constaninescu C, Ealing J, Hawkins C, Morrison K , Palace J et al (2012) Work in progress: quality of life (QoL) and neurological disease - trajectories of outcome in neurological conditions (TONiC): a study protocol. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 19 (pp 264-264) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) . Neurology, Vol. 78(Meeting Abstracts 1) (pp P03.180-P03.180) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) . Neurology, Vol. 78(Meeting Abstracts 1) RIS download Bibtex download
  • Hewamadduma C, Higgenbottom CAA, Moens C, Helde K, Raman R, Tennore R, Grierson A & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.116-e1) RIS download Bibtex download
  • Aridegbe T, Kandler R, Walsh T, Shaw PJ & McDermott CJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.108-e1) RIS download Bibtex download
  • Brockington A, Ning K, Heath P, Wood E, Malik K, Fusi N, Wharton S, Ince PG & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.110-e1) RIS download Bibtex download
  • Rajan S, Shaw P & Wood-Allum C (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.26-e1) RIS download Bibtex download
  • Ramesh T, McGown A, Al Mashhadi S, Redhead N, Lyon A, Bettie CE & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.122-e1) RIS download Bibtex download
  • Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.115-e1) RIS download Bibtex download
  • McDermott C, Proctor A, Walsh T, Ackroyd R, Rao G, Bianchi S, Englert L, Rafiq MK & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.120-e1) RIS download Bibtex download
  • Smith BN, Topp S, Barwell J, Al-Chalabi A, Kirby J, Shaw PJ, Paul H, Morrison KE, de Jong V, Baas F , Lewis CM et al (2012) Age-dependent penetrance and anticipation in ALS+/-FTLD kindreds due to C9ORF72 hexanucleotide intronic repeat expansion mutations (C9HIREM). DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, Vol. 33 (pp 282-282) RIS download Bibtex download
  • Smith BN, Topp S, Barwell J, Al-Chalabi A, Kirby J, Shaw PJ, Paul H, Morrison KE, de Jong V, Baas F , Lewis CM et al (2012) Age-dependent penetrance and anticipation in ALS+/-FTLD kindreds due to C9ORF72 hexanucleotide intronic repeat expansion mutations (C9HIREM). DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, Vol. 33 (pp 36-37) RIS download Bibtex download
  • Baxter SK, Baird WO, Thompson S, Bianchi S, Walters S, Ahmedzai SH, Proctor A, Shaw PJ & McDermott CJ (2012) The Use of Non-Invasive Ventilation for Patients with Motor Neurone Disease: Patient and Carer Perceptions of Obstacles and Outcomes. ANNALS OF NEUROLOGY, Vol. 72 (pp S73-S74) RIS download Bibtex download
  • Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiology of Aging RIS download Bibtex download
  • Bunting E, Wood-Allum C, Barber S & Shaw P (2011) Congruent handedness and side of onset in ALS-evidence in favour of the exercise hypothesis?. JOURNAL OF NEUROLOGY, Vol. 258 (pp 57-57) RIS download Bibtex download
  • Eckmann J, Eckert SH, Leuner K, Bordet T, Pruss R, Grierson A, Shaw P, Clemens L, Nguyen HP, Mueller WE & Eckert GP (2011) Impact of Olesoxime on disease related mitochondrial membrane properties in mouse models of neurodegenerative diseases. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol. 383 (pp 51-51) RIS download Bibtex download
  • Simpson JE, Ince PG, Heath PR, Raman R, Shaw PJ, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33) RIS download Bibtex download
  • Highley R, Kirby J, Jansweijer JA, Heath PR, Shaw PJ & Ince PG (2011) TARDBP mutations, amyotrophic lateral sclerosis and alternative splicing. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 20-20) RIS download Bibtex download

Other

  • McDermott CJ & Bradburn MJ (2016) . The Lancet Neurology, 15(6), 543-544. RIS download Bibtex download

Preprints

  • Grant OA, Iacoangeli A, Zwamborn RAJ, van Rheenen W, Byrne R, Van Eijk KR, Kenna K, van Vugt JJFA, Cooper-Knock J, Kenna B , Vural A et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Weinreich M, McDonough H, Yacovzada N, Magen I, Cohen Y, Harvey C, Gornall S, Boddy S, Alix J, Mohseni N , Kurz JM et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Pham TK, Verber N, Turner MR, Malaspina A, Collins MO, Mead RJ & Shaw PJ (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • McKinnon S, Qiang Z, Keerie A, Wells T, Shaw PJ, Alix JJP & Mead RJ (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Zhang S, Moll T, Rubin-Sigler J, Tu S, Li S, Yuan E, Liu M, Butt A, Harvey C, Gornall S , Alhalthli E et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Iacoangeli A, Dilliott AA, Al Khleifat A, Andersen PM, Ba艧ak NA, Cooper-Knock J, Corcia P, Couratier P, de Carvalho M, Drory V , Glass JD et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Lin Y-H, Dodd JE, Cutillo L, Castelli LM, Mihaylov SR, Norris K, Higginbottom A, Walsh MJ, Cooper-Knock J, Highley JR , Granata I et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Burrows DJ, McGown A, Abduljabbar O, Castelli LM, Shaw PJ, Hautbergue GM & Ramesh TM (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Michael B, Wood G, Sargent B, Ahmad Z-U-A, Tharmaratnam K, Dunai C, Egbe F, Martin N, Facer B, Pendered S , Rogers H et al (2024) , Research Square Platform LLC. RIS download Bibtex download
  • Kalia M, Spargo TP, Al Khleifat A, Opie-Martin S, Kabiljo R, Dobson RJB, van Damme P, Corcia P, Couratier P, Hardiman O , McLaughlin R et al (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Spargo TP, Marriott H, Hunt GP, Pain O, Kabiljo R, Bowles H, Sproviero W, Gillett AC, Fogh I, Andersen PM , Ba艧ak NA et al (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Bell SM, Wareing H, Hamshaw A, De S, New E, Shaw PJ, De Marco M, Venneri A, Blackburn DJ, Ferraiuolo L & Mortiboys H (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Kalia M, Miotto M, Ness D, Opie-Martin S, Spargo TP, Di Rienzo L, Biagini T, Petrizzelli F, Al-Khleifat A, Kabiljo R , Topp S et al (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Marriott H, Spargo TP, Khleifat AA, Fogh I, Andersen PM, Ba艧ak NA, Cooper-Knock J, Corcia P, Couratier P, de Carvalho M , Drory V et al (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Adey BN, Cooper-Knock J, Khleifat AA, Fogh I, van Damme P, Corcia P, Couratier P, Hardiman O, McLaughlin R, Gotkine M , Drory V et al (2022) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Byrne RP, van Rheenen W, van den Berg LH, Veldink JH & McLaughlin RL (2020) , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
  • Adrian Higginbottom
  • Laura Evans
  • Aytac Gul
  • Ilaria Giovanelli
  • Simon Bell
  • Anushka Bharkava
  • Marco Destro
  • Ana Aragon Gonzalez
  • Allan Shaw
  • Tobi Moll
  • Calum Harvey
  • Selina Beal
  • Kriti Gupta
  • Kayal Mujthukrishnan
  • Deborati Bhattachryya
  • Ekene Anakor
  • Thomas Marlow
  • Raquel Rua Martins
  • Aoife Kernan
  • Laura Chapman

SITraN PI Scientific Collaborators

  • Laura Ferraiuolo
  • Robin Highley
  • Richard Mead
  • Janine Kirby
  • Scott Allen
  • Guillaume Hautbergue
  • Mimoun Azzouz
  • Johnathan Cooper-Knock
  • James Alix
  • Tennore Ramesh
  • Ryan West
  • Kurt de Vos
  • Christopher McDermott

Current Clinical Research Team

  • Mbombe Kazoka
  • Lee Tuddenham
  • Madalina Roman
  • Mary Sikaonga
  • James Alix
  • Stacy Young
  • Johnathan Cooper-Knock
  • Calum Harvey
  • Daniel Madarshahian
  • Aoife Kernan
Grants

Principal Funding Sources

  • The Motor Neurone Disease Association
  • The Medical Research Council
  • LifeArc
  • NIHR
  • My Name鈥5 Doddie Foundation
  • European Union
  • Pharmaceutical partners
Professional activities and memberships

Professor Shaw has served as a member of multiple national and international committees, and has been a research advisory panel member for the Wellcome Trust, MNDA, MRC, the Muscular Dystrophy Association, the Academy of Medical Sciences, the Academy of Science Finland, NIHR and reviews for multiple grant awarding bodies.

Current Membership of National and International Committees

  • Academy of Medical Sciences New Lectureship Panel Fellowship Panel 2020 - present.
  • Lister Institute Board of Governors 2018 鈥 present
  • UKRI Future Leaders Fellowship Panel and College 2020- present
  • NIHR Senior fellowship panel 2021 鈥 present
Postgraduate awards
  • 2022 British Neuroscience Association Award for Outstanding Contribution to Neuroscience
  • 2022 Award of the 2nd Dr M Gourie Devi Oration, National Institute of Mental Health and Neuroscience, Bengaluru, India
  • 2022 Oktoberfest Plenary Lecture, Ludwig-Maximilian University of Munich
  • 2021    Singhal award Lecture XXV World Congress of Neurology, Rome.
  • 2019    National Queen鈥檚 Anniversary Prize 2019 for excellence and innovation in Neuroscience awarded to the 91探花 Institute for Translational Neuroscience.
  • 2019    European Academy of Neurology Moritz Romberg Lecture
  • 2019    Association of British Neurologists 2019 Medallist
  • 2018/19 The Physiological Society GL Brown Prize Lectures
  • 2018    Science and Society Public Lecture University of Liverpool, June 2018.
  • 2017    Honorary Doctor of Medicine, University of Sussex in recognition of major contribution to the field of Neurology.
  • 2017 Kosterlitz Prize and Lecture, University of Aberdeen.
  • 2017 Honorary Degree, University of Bradford for internationally recognized work in the field of Neurology and instrumental work in setting standards of excellence in the clinical care for patients.
  • 2017 Honorary Doctor of Medicine, University of Sussex in recognition of major contribution to the field of Neurology.
  • 2017 University of Sussex Brain Visiting Professorship
  • 2017 Kosterlitz Lecture, University of Aberdeen.
  • 2016 Croonian Lecture, UK Royal College of Physicians
  • 2015 Osler Lecture, Association of Physicians of the United Kingdom and Ireland
  • 2015 Elected Fellow of the American Association for the Advancement of Science for groundbreaking basic and translational research of relevance to the understanding and treatment of neurodegenerative diseases.
  • 2014 Dame Commander of the Order of the British Empire (DBE) for services to Neuroscience
  • 2014 Jacobson Visiting Professorship, University of Newcastle upon Tyne
  • 2013 Alfred Meyer鈥檚 Memorial Award Lecture British Neuropathological Society
  • 2013 NIHR Senior Investigator Award
  • 2013 UK ACCEA Platinum Clinical Excellence Award
  • 2012 Gary and Peggy Edwards Distinguished Visiting Professorship for ALS, Houston USA
  • 2012 Elected President of the North of England Neurological Association
  • 2012 Visiting Professorship, Association of Physicians (Kerala Chapter) India
  • 2012 Elected to membership of the Medical Pilgrims
  • 2007 The International ALS/MND Forbes Norris Award for excellence in research and compassion in clinical care
  • 2007 Fellowship of the Academy of Medical Sciences
  • 2007 Spinoza Visiting Professorship, University of Amsterdam
  • 2006 Royal College of Physicians Jean Hunter Prize for research into nervous disorders
  • 2004 Invited Fellowship of the American Neurological Association
  • 2001 American Academy of Neurology and ALS Association Sheila Essey Award for outstanding research contribution in amyotrophic lateral sclerosis/ motor neurone disease
  • 2000 Hong Kong Neurological Association Li Po Shan/ Dr Vincent Liu visiting Professorship
  • 1997 Invited Fellowship of the American Academy of Neurology
  • 1996 Renewal of Wellcome Senior Fellowship in Clinical Science
  • 1995 British Medical Association Vera Down Award
  • 1992 Poster Research prize at the Third International Symposium on ALS/MND
  • 1991 Award of Wellcome Senior Fellowship in Clinical Science
  • 1991 Association of British Neurologists Sir Charles Symonds Prize
  • 1990 North of England Neurological Association Liversedge Research Prize
  • 1985 Northern Regional Health Authority David Dickson Research Prize
  • 1985 Association of Physicians UK Dewar Research Prize
  • 1985 British Cardiac Society Young Investigator of the Year award