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Alexanderwerk group is a leading manufacturer of high-technology compaction and granulation machines for the chemical, food, life science, nuclear and pharmaceutical industries. For decades, pharmaceutical and chemical companies all over the world have been using solutions supplied by Alexanderwerk.

Alexanderwerk specialises in the development and production of roller compaction and granulation machines for the chemical and pharmaceutical industries. With their (as seen at University of 91̽��) Alexanderwerk offers a roller compactor specifically designed for use in R&D departments or small scale production. Even batches of as little as 5g can be processed on the WP 120 Pharma.

Alexanderwerk AG
Alexanderwerk GmbH
Kippdorfstrasse 6-24, 42857 Remscheid
Tel: +49 2191 795-0
E-mail: contact@alexanderwerk.com
Website:

A global full service company founded in 1972, Freund-Vector Corporation designs, manufactures and markets processing equipment and services for the processing of powders, particles, beads, pellets, tablets and other solid materials/forms to the pharmaceutical, nutritional, food, confectionery, chemical, powdered metals, automotive and pyrotechnics industries. Equipment applications include coating, drying, agglomerating, granulating, layering, densification and tablet forming.

The product lines include for applying an aqueous, solvent or sugar film coating;  for granulating, coating and drying; high shear granulator mixers for wet granulation and roll compactors for material densification and granulation along with automated process control systems for all of the equipment/systems. A unique in-house that specializes in product feasibility, process development and process technology provides processing expertise to support the marketing of all of the product lines.
A key to Freund-Vector’s continued growth and profitability, in an increasingly competitive global market, is a dedicated work force of well-educated and experienced employees. Freund-Vector has a very strong commitment to quality and was assessed and is a registered International ISO 9001:08 Quality Manufacturing Company.

Ownership

Freund Corporation of Tokyo, Japan a business partner since 1974 purchased controlling interest of Vector Corporation in 1997. Freund Corporation is a highly focused product research and development based company. Freund is committed to the continued development of innovative processing equipment and to provide new technology solutions for the pharmaceutical and nutritional markets. Freund possesses more than 300 domestic and international intellectual properties reflecting their creative technologies and unique products. Together Freund and Vector have over 5000 installations in 51 countries of the world.
Vector Corporation became Freund-Vector Corporation in January 2012.

Freund-Vector Corporation
675, 44th Street
Marion, Iowa
52302, United States of America
Tel.: +1-319-377-8263
Contact: Steve Kray (Marketing Product Manager)
Email: steve.kray@freund-vector.com
Website: 

Glatt is a full-service provider and offers integrated process solutions throughout the entire value chain: from primary particle manufacturing to refining and right up to finished tablets. Glatt is an international operating family owned company with 15 subsidiaries and 3000 employees around the world. The headquarter is located in Binzen in the south-west of Germany.
Glatt covers four areas of expertise:

Process Technology Pharma develops and produces individual production plants for the production and processing of solid dosage forms, like tablets, capsules or pellets. The service portfolio includes integrated process solutions from engineering up to manufacturing. The batch processing technology developments started in 1954 and our continuous processing developments 10 years later in 1964.

Pharmaceutical Services develops solid pharmaceutical dosage forms, with focus on multiparticulate systems, such as pellets, granules, tablets and capsules. The service portfolio covers the full range from feasibility studies & the formulation development over the production of samples for clinical trials, the bulk manufacturing of medicines up to logistic services.

Process Technology Food, Feed & Fine Chemicals develops, plans and distributes fluidized & spouted bed systems for the food, feed and chemical industries. The service portfolio covers the entire value chain, from particle design to industrial production.

Process & Plant Engineering plans, engineers and implements plant projects for the pharmaceutical, biotechnological, fine chemical and the cosmetics industry. The service portfolio ranges from the expansion or modernization of existing production sites to the new construction of an entire plant.

Glatt GmbH
Process Technology
Werner-Glatt-Straße 1
79589 Binzen, Deutschland
Phone: +49 7621 664-0
E-mail: info@glatt.com

Granutools improves powder understanding by delivering leading edge physical characterization tools. “All we do is powder flow characterization”

PHYSICAL INSIGHTS
Combining decades of experience in scientific instrumentation with fundamental research on powders characterization, our tools are designed for accuracy, repeatability and operator independence with strict initialization protocols and high level of automation.
Therefore, the measurables lead to the physical understanding of powder mechanisms.

Our tools have been developed to help you to answer the following questions:

- High resolution tapped density analyzer - Granular material density analyzer - Automated tapped density and compaction dynamic measurements

- Granular material electric charge analyzer - Electrostatic charge measurement of a flowing powder on a surface

- Automated instrument able to set a desired humidity level inside a chamber (with a volume lower than 200L). Usually this instrument works paired with the GranuCharge in order to study the influence of humidity on triboelectricity

GRANUTOOLS
Rue J-L Defrêne 107
4340 AWANS
BELGIUM
+32 4 384 00 74
+32 483 19 83 39
contact@granutools.com

WORKFLOWS
We follow a general principle for powder flow measurement: “The stress state and the flow field of the powder should be comparable in the measurement cell and in the process.”
Our instruments mimic processes at a different scale.
The complementary instruments are then combined into workflows to reproduce each step of the processes we want to characterize.

- Granular material flowmeter - Semi-automated measurement of powder flow rates through apertures

- Granular material heap analyzer - Automated repose angle and cohesive index measurements

- Granular material flow analyzer – Powder rheometer - Automated cohesive index and rheology measurements

Hosokawa Micron B.V., located in the Netherlands, is specialised in Mixing, Drying, Agglomeration and allied Powder Processing Systems. The main activities are concentrated in the field of design and supply of equipment and systems for mechanical and thermal processing of dry and wet powders.

Hosokawa Micron's main goal is to be leading in the field of powder processing technology and to offer superior products and systems which are always one step ahead of others.
Constant efforts and improvements supported by Hosokawa Micron's intensive R&D programs, combined with many decades of practical expertise from the field, have led to an unique range of products which are continuously setting new standards in powder processing technologies.

Hosokawa Micron B.V. focuses its expertise on three core businesses:

Hosokawa Micron has developed a wide range of innovative mixing equipment and technologies for powders, pastes, slurries and liquids. Our mixing technologies can be used for a multitude of applications, like homogenizing bulk materials, improving product quality, coating particles, fusing materials, wetting, dispersion of liquids, altering functional properties and agglomeration.

Looking for industrial dryers to effectively reduce the moisture level of your product? Hosokawa Micron has developed a wide range of innovative (freeze) drying and cooling technologies for powders, pastes, slurries and liquids.

Hosokawa Micron provides the solids and bulk handling industry with process equipment for the agglomeration of fine powders and particles, also called wet granulation or particle size enlargement. Agglomeration solutions are great tools for improving physical properties like flowability, wettability and dispersability, bulk density and product appearance.

The company's strong emphasis on system design capability is backed up by and tolling facilities to support you in finding optimal solutions for your applications. This service is supported by a group of process, mechanical, electrical and project engineering specialists each with specific know how for the design and performance of complete systems and plants.

Hosokawa Micron BV
Gildenstraat 26
7005 BL Doetinchem
The Netherlands
Phone: +31 314 373 333
e-mail: info@hmbv.hosokawa.com

The Parsum principle: Particle measurement directly within the process

The well-known technique of fibre-optic spatial filter anemometry was developed by Parsum so that not only the velocities of particles could be measured, but also their sizes. Unlike traditional particle size measuring methods that involve sampling and laboratory analysis, Parsum has always used inline measurement right from the start. Several patents have been granted for this method in Germany, Europe and the USA.

The consistent development of accessories for process adaptation – the so-called “process interface” – has been the principal factor in allowing Parsum to establish itself as the market leader in the area of particle measurement in Fluidised Bed and High-Shear Granulation processes. With the new inline dispersers, Parsum probes can perform measurements even in very high-load, wet and dusty processes.

Parsum has installed more than 380 measuring systems in 24 countries to date. In addition to global pharmaceutical firms and companies in the food and chemical sectors, its customer base also includes numerous universities and research institutions. For international distribution, Parsum has had UK-based Malvern Instruments Ltd. on side as a partner since 2003.In several R&D projects carried out in cooperation with customers, plant manufacturers and universities; Parsum has put a lot of investment into the advanced development of its particle probes in recent years.

The Parsum Inline Particle Probes make it possible to carry out inline monitoring of all granulation processes and allows for the real-time visualisation of granulate growth in batch processes or constant product quality in continuous processes. Critical parameters for these processes, such as spray rate, temperature, air volume, contact pressure, rotational speed, binder amounts, spray pressure, etc., can be controlled and optimised for the specific product. The final granulate size can therefore be accurately defined and the process time for batch processes can be reduced. In continuous processes, trends and quality fluctuations can be detected at an early stage.

Parsum Inline Particle Probes:

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Parsum Case studies:

Contact information:
Reichenhainer Strasse 34-36
09126 Chemnitz, Germany
Tel: +49 (0) 371 2675869-0
Fax: +49 (0) 371 2675869-9
info@parsum.de

Dynamic Vapor Sorption (DVS)
ProUmid manufactures and sells fully automated gravimetric vapor sorption systems. The multi-sample capacity of the instruments with up to 23 sample positions ensures a high sample throughput. Sorption isotherm and sorption kinetics are determined within a broad temperature and humidity range. Our sorption systems combine an easy operation with a robust design for accurate and reliable measurement results.

Humidity Generators
The humidity generators of the MHG series are designed for fast and accurate control of relative humidity in small specimen chambers of analytical equipment as well as large chambers and technical environments. The modular design enables to adapt the humidity generators to all kind of applications. Typical applications are XRPD, TGA, DMA, powder rheometer, microscopy, glove boxes and customer specific measurement chambers.

Powder Equilibration
The ProUmid powder conditioner enables simple and fast moisture equilibration of powders, granules or pellets at controlled relative humidity. The powder conditioner replaces large volume climatic chambers and laborious handling of salt solutions in desiccators. Additionally, the system enables to determine the moisture content of the equilibrated powder.

ProUmid GmbH & Co. KG
August-Nagel-Str. 23
89079 Ulm
Germany

Contact: Roman Kirsch
E-mail: r.kirsch@proumid.com
Tel.: +49 (0) 7305 2030 442
Web: 

The Fitzpatrick Company

Innovation In Particle Processing Technology

The Fitzpatrick Company, a unit of IDEX MPT, Inc. manufactures the FitzMill™ Comminutor for precise particle size reduction, and the Chilsonator® Roll Compactor for dry granulation/powder agglomeration. Fitzpatrick engineers and manufactures particle processing equipment for size reduction and dry granulation applications that offer enhanced ROI in subsequent processing steps, by improving powder characteristics such as flow and compressibility, and reducing segregation potential. Modern containment designs employ current Good Manufacturing Practices (cGMP) for ease and reliability of cleaning. The Fitzpatrick Company offers proven, high-performance solids processing equipment for a wide range of products including pharmaceuticals, bulk chemicals, cosmetics, food and veterinary medicines. The Fitzpatrick Company offers fully scalable solutions with repeatable results, backed by decades of hands-on application knowledge and a worldwide sales & processing support structure.

The Fitzpatrick Company
613 Colby Drive
Waterloo, Ontario
N2V 1A1 Canada
Telephone: +1-519-884-9660
Fax: +1-519-884-0253
Email: fitzinfo@idexcorp.com
Web: 

Quadro Engineering Corp.

Industry Leader In Process & Size Reduction Equipment

Quadro Engineering Corp., a unit of IDEX MPT, Inc. is the originator of the conical screen mill. For more than four decades, Quadro Engineering’s cutting-edge equipment designs and relentless innovation have combined to allow for significantly streamlined manufacturing solutions. With Quadro Engineering products, customers know they can expect to achieve unmatched coarse-to-fine particle/powder size reduction and milling results, and the highest returns-on-investment. Quadro has developed the world’s leading technology for achieving uniform size reduction, sieving, deagglomeration and dispersion. Quadro manufactures an innovative line of size reduction mills, fine grind mills, and security screeners for the Pharmaceutical and associated industries. Services include custom equipment engineering, process testing at our R&D Test Center, a complete Parts & Service Program, and an In-Plant Trial Program featuring a wide range of Quadro's equipment.

Quadro Engineering Corp.
613 Colby Drive
Waterloo, Ontario
N2V 1A1 Canada
Telephone: +1-519-884-9660
Fax: +1-519-884-0253
Email: quadrosales@idexcorp.com
Web:

Use is guaranteed even under extreme conditions (high temperatures and pressure ranges)

develops and sells photo-optical and image-based analysis measurement technology that quantitatively characterizes particulate multi-phase systems. In combination with SOPAT hardware, real time analysis of particle size distribution and characteristics is made possible with the innovative company software.

The goal is to produce particle measurement systems tailor made for customers worldwide that allow for the early detection of trends and efficient process optimization. This advantage leads to time and personnel cost reductions that increase product quality as well as considerably reduce waste.

Whether the system contains emulsions, crystallization, or polymerization, diverse applications are possible with SOPAT’s innovative particle size analysis technology, be it concentration, size, form, or distribution. Measurements occur inline during the production process, so neither sampling nor dilution is necessary. This guarantees that the sample is neither changed on the way to the laboratory, nor must production be stopped.

The Benefits of SOPAT Particle Measuring Technology:
• Inline Measurement
• Real Time Process Monitoring
• Simultaneous Analysis of Diverse Particles
• Process Optimization
• Quality Control

Solutions in Particle Sizing

Retsch Technology develops, sells, supports and services the state-of-the-art CAMSIZER range of optical measuring systems for particle characterization measuring both Particle Size and Shape by Digital Image Analysis:

• Measuring range from 0.8 micron to 30mm
• Analysis of particle size and shape of colloidal materials, emulsions, suspensions, dispersions, powders and granulates.

RETSCH Technology’s  and CAMSIZER X2 particle analyzers use the principle of Dynamic Image Analysis. This is a powerful state-of-the-art method for particle size and shape characterization of powders, granules and suspensions. This methodology is superior to the others in its resolution, precision and reproducibility and delivers additional detailed particle shape information. Typical analysis time is 3 to 5 minutes with excellent reproducibility.

Parsons Lane, Hope, Hope Valley, S33 6RB
Tel: +44 (0) 845 458 5196
E-mail: info@retsch.co.uk
Web:

Thermo Fisher Scientific is the world leader in serving science. We help pharmaceutical customers accelerate innovation and enhance productivity by supplying innovative solutions with applications that span the drug discovery process – from formulation through manufacturing. Our broad range of solutions include:

Visit our stand to take a closer look at the . This unique, flexible extruder for hot melt extrusion and continuous granulation - helps scientists in the early development of new drug research and development formulation.

Thermo Fisher Scientific
Stafford House
Boundary Way
Hemel Hempstead
HP2 7GE
United Kingdom
Tel.: 44 (0) 1442 233555
E-mail: dirk.leister@thermofisher.com

Fluid Air has established itself as an innovator in developing equipment for the modification and creation of powders and particles, & provider of customized solutions to solid dosage process challenges across several industries including pharmaceuticals, foods, fine chemical & cosmetics. With our newest technology, the patent-pending PolarDry® Electrostatic Spray Dryers produce a faster, continuous process that eliminates active ingredient loss, creates a higher bulk density, and has longer shelf life because of lower drying temperatures. They also eliminate the need of purchasing a secondary piece of equipment since drying and agglomeration operations are done in the same process, very cost effective. We've developed revolutionary technology for our customers on a global scale & cultivated a strong international presence with best-in-class service.

Stephane Lecuyer
Fluid Air West Europe
Division of Spraying Systems Co®
Experts in Spray Technology
Phone (33) 1 46 20 96 40 / 96 41
Fax (33) 1 42 53 17 34
stephane.lecuyer@spray.com

Leistritz is one of the leading companies in the field of twin screw extruders and extrusion lines.
Compounding with co-rotating twin-screws has been successfully applied in the plastics industry for decades. Now it is a proven system for hot melt extrusion, granulation, lipid extrusion, transdermals and implants.

The continuous extrusion process is being applied in many fields of life sciences and the pharmaceutical industry. In various processes – hot melt extrusion, granulation, lipid extrusion – the usage of co-rotating twin screws is well established.

Leistritz was a pioneer when pharmaceutical extrusion started: Our extruders have been used in the pharmaceutical industry for over 30 years. Today, we are a technology leader in pharma and life science extrusion. We have extensive knowledge in the areas of process technology, GMP design, plant engineering, and qualification.

Apart from the use in the pharmaceutical sector for the manufacturing of, for example, granules, pellets, implants or contraceptive vaginal rings, Leistritz technology comes also into effect in the following fields:

↗ Nutraceuticals, for example in the manufacturing of functional food or dietary supplements (such as the incorporation of omega-3 fatty acids or amino acids into the excipient)
↗ Cosmeceuticals, for example in the incorporation of active ingredients or vitamins
↗ Foods, for example the incorporation of starch, the manufacturing of meat substitutes or rice crisps

With its large wealth of experience in the fields of process technology, GMP design, plant engineering and qualification, Leistritz assists you as a competent partner: from the development stage right up to the production phase.

We offer valuable process know-how and engineering experience from the production of tablet masses, micro pellets for the use in capsules to transdermal applications. For the special demands in this sensitive application area the German extruder manufacturer offers a range of extruders and auxiliary equipment in GMP design.

Leistritz has subsidiaries, sales and service branch offices in the main markets of Europe, the USA and Asia, while machinery is manufactured in Germany. The headquarters of Leistritz in Nuremberg, Germany, accommodate administration, development and production facilities as well as completely equipped laboratories for process technology.

Leistritz Extrusionstechnik GmbH
Markgrafenstr. 36-39
90459 Nuremberg
Germany
Tel.: +49 (0) 911 / 43 06 0
E-Mail: extruder@leistritz.com
Website: 

A love of research and high quality standards have made Anton Paar a world market leader in the fields of density measurement, the determination of dissolved CO2, rheometry, material and particle characterization and the production of complex high-precision parts, e.g. for medicinal prostheses. Innovation is essential: About 20 % of the company’s annual turnover is invested in Research & Development. Anton Paar provides solutions to industries in over 110 countries. Customers include, among others, the world’s largest soft drink producers, all major breweries, Formula 1, the chemical and pharmaceutical industry and food producers, including chocolate manufacturers.

Anton Paar GmbH is owned by the Santner Foundation, which is exclusively and directly aimed at charitable causes.

Anton Paar Switzerland AG
Pulverhausweg 13
5033 Buchs
SWITZERLAND
Tel.+41 (0) 62 745 16 80
Fax +41 (0) 62 745 16 81
info.ch@anton-paar.com

Surface Measurement Systems develop and engineer gravimetric sorption analyzers and inverse gas chromatography instruments for physico-chemical characterization of solid state materials. Our instruments can be used for studying sorption and desorption isotherms, vapor and gas diffusion kinetics, hysteresis effects, stability studies, water activity, phase transformations, amorphous content, permeability, surface energy heterogeneity, dispersive and acid-base surface energy, solubility parameters, heats of adsorption and works of adhesion and cohesion.

We are world leaders in sorption science and inventors of Dynamic Vapour Sorption (DVS) technology and Inverse Gas Chromatography (IGC) instrumentations. We provide professional world-class scientific and technical support for all our customers and our products are used by hundreds of leading laboratories and universities globally.

Inverse Gas Chromatography - Surface Energy Analyzer (iGC-SEA)
This system is specially designed to determine the surface energy heterogeneity but nevertheless suitable for measuring different surface and bulk properties of solid materials including acid / base properties, heat of sorption, glass transition temperature, solubility parameters and so on.

Dynamic Vapor Sorption (DVS)
This system allows for real-time monitoring and controlling of vapor and gas concentration for sorption measurements in solid state materials. The sorption mechanism may be investigated from sorption / desorption isotherms, hysteresis effects, and sorption kinetics. The combination of a video microscope and vibrational spectroscopic techniques with DVS would allow for increased understanding of vapor-induced structural changes of solid materials.

Vapor Pressure Analyzer (VPA)
The Vapor Pressure Analyzer or VPA measures the vapor pressures of solids, liquids and oils using the Knudsen effusion method.

Telephone number: +44 (0) 208 795 9400
Contact Email: sales@surfacemeasurementsystems.com
Website: 

PSE is the world’s foremost provider of  software and services for digital design and operation to the process industries. Companies apply digital design to explore the process decision space rapidly and effectively, in order to reduce uncertainty and make better, faster and safer formulation, process design and operating decisions.

PSE provides the  modelling suite for optimising the formulation and manufacture of drug substances and drug products using mechanistic process and material models of unit operations – such as crystallization, spray drying and granulation – combined with in-vitro/vivo product performance models.

Use of PSE’s technology and services results in faster innovation, more rapid formulation screening, improved process and product designs, enhanced operations, reduced risk, more effective R&D and experimental campaigns and better capture and transfer of corporate knowledge across the organisation.

The company is pioneering the emerging science of  with Eli Lilly, Pfizer, GSK and Roche, and is the leader of the £20.4m digital design .

Process Systems Enterprise Limited
5th Floor East, 26-28 Hammersmith Grove,
London W6 7HA, United Kingdom
Tel: +44 20 8563 0888
E-mail: info@psenterprise.com
Website: