Professor Nicholas Latimer
BSc, MSc, PhD
Population Health, School of Medicine and Population Health
Professor of Health Economics
+44 114 222 0821
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
91探花
S1 4DA
- Research interests
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My research interests focus on economic evaluation methodology, with a particular emphasis on the incorporation of survival analysis within economic models. I am especially interested in the use of causal inference methods to estimate comparative effectiveness in clinical trials confounded by treatment switching, and in observational (or 鈥淏ig鈥, or 鈥淩eal World鈥) data.
My past research focused primarily on methods for adjusting survival estimates in the presence of treatment switching - that is, when patients in the control group of a clinical trial switch onto the experimental treatment, thus confounding estimates of the treatment effect (where the relevant question for an economic analysis is what would have happened if control group patients did not receive this experimental treatment).
I am currently undertaking a Senior Research Fellowship funded by Yorkshire Cancer Research. During this Fellowship, my focus is on investigating the use of cancer registry datasets to estimate the comparative effectiveness of cancer treatments used in the NHS.
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I also have an active interest in economic evaluations alongside clinical trials, and particularly the incorporation of value of information analysis in feasibility trials.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Statistical Methods in Medical Research.
- . Value in Health.
- . Medical Decision Making.
- . Medical Decision Making, 37(4), 377-390.
- . Statistical Methods in Medical Research, 26(2), 724-751.
- . The Oncologist, 20(7), 798-805.
- . Expert Review of Pharmacoeconomics & Outcomes Research, 15(4), 561-564.
- . PharmacoEconomics, 32(12), 1171-1183.
- . Med Decis Making, 34(3), 387-402.
- . Pharmaceutical Statistics, 12(6), 348-357.
- . BMJ, 346, f1363.
- . Med Decis Making, 33(6), 743-754.
- . BMC Med Res Methodol, 11, 4.
- . BMJ, 339, b2538.
All publications
Journal articles
- A comparison of the effectiveness of different treatment regimens for pancreatic cancer using English cancer registry data. SCHARR HEDS Discussion Paper(24.05).
- . PharmacoEconomics.
- . PharmacoEconomics.
- . BMC Cancer, 24(1), 879.
- . Value in Health, S1098-3015(23)06241.
- . Value in Health, 26(12), S394-S394.
- . Value in Health, 26(12), S13-S13.
- . Value in Health, 26(12), S423-S424.
- . Value in Health, 26(12), S421-S422.
- . Value in Health, 26(12), S365-S365.
- . Brain and Behavior, e3331.
- . PharmacoEconomics, 1-12.
- . Value in Health.
- . Medical Decision Making, 43(5), 610-620.
- TREATMENT EFFECT WANING IN IMMUNO-ONCOLOGY HEALTH TECHNOLOGY ASSESSMENTS: A REVIEW OF ASSUMPTIONS AND SUPPORTING EVIDENCE. VALUE IN HEALTH, 26(12), S365-S365.
- A REVIEW OF EXTERNAL EVIDENCE USED TO SUPPORT SURVIVAL EXTRAPOLATION IN ASSESSMENTS OF CANCER DRUGS BY THE NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE (NICE). VALUE IN HEALTH, 25(12), S340-S340.
- . Value in Health.
- . Transplant International, 35.
- . Pilot and Feasibility Studies, 8(1), 74-74.
- . PharmacoEconomics.
- . BMJ Medicine, 1.
- . JAMA : the Journal of the American Medical Association, 325(20), 2110-2111.
- . Expert Review of Pharmacoeconomics & Outcomes Research.
- . PharmacoEconomics.
- . Clinical Kidney Journal.
- . Value in Health.
- . Health Technology Assessment, 24(19), 1-176.
- . Statistical Methods in Medical Research.
- . Value in Health.
- . Medical Decision Making.
- . Advances in Therapy.
- . Medical Decision Making.
- . The Lancet Diabetes & Endocrinology, 7(10), 750-751.
- . The Lancet Neurology, 18(9), 821-833.
- . Health Technology Assessment, 23(47), 1-176.
- . Statistical Methods in Medical Research, 28(8), 2475-2493.
- . Value in Health, 22(7), 772-776.
- . PharmacoEconomics, 1-10.
- . BMC Medical Research Methodology, 19, 69-69.
- . Value in Health.
- . International Journal of Technology Assessment in Health Care, 34(3), 300-316.
- . PharmacoEconomics.
- . Statistical Methods in Medical Research, 27(3), 765-784.
- . PharmacoEconomics.
- . Medical Decision Making, 37(4), 377-390.
- . Statistical Methods in Medical Research, 26(2), 724-751.
- . Targeted Oncology, 12(1), 111-121.
- . International Journal of Technology Assessment in Health Care, 32(3), 167-174.
- . International Journal of Technology Assessment in Health Care, 32(3), 160-166.
- . Pilot and Feasibility Studies, 2(1).
- . Value in Health.
- . Cancer Medicine, 5(5), 806-815.
- . Oncology, 90(3), 119-126.
- . Value in Health, 18(3), A195-A195.
- . Trials, 16(1).
- . Value in Health, 18(7), A700-A700.
- . Value in Health, 18(7), A687-A687.
- . Melanoma Research, 25(6), 528-536.
- . The Oncologist, 20(7), 798-805.
- . Expert Review of Pharmacoeconomics & Outcomes Research, 15(4), 561-564.
- . Aphasiology, 29(7), 763-780.
- . PharmacoEconomics, 32(12), 1171-1183.
- . Frontiers in Psychiatry.
- . Med Decis Making, 34(3), 387-402.
- . Med Decis Making, 34(3), 279-282.
- . Health Technol Assess, 18(13), 1-210.
- . Health Technol Assess, 18(36), 1-viii.
- . Pharmaceutical Statistics, 12(6), 348-357.
- . Int J Technol Assess Health Care, 29(4), 402-409.
- . Age Ageing, 42(5), 641-645.
- . Journal of Clinical Oncology, 31(15_suppl), 9040-9040.
- . Journal of Clinical Oncology, 31(15_suppl), 636-636.
- . Journal of Clinical Oncology, 31(15_suppl), 9044-9044.
- . BMJ, 346, f1363.
- . Alcohol Alcohol, 48(2), 180-188.
- . Medical Acupuncture, 25(1), 2-4.
- . Med Decis Making, 33(6), 743-754.
- . Acupuncture in Medicine, 30(3), 182-186.
- . Stroke, 43(7), 1904-1911.
- . Epilepsy and Behavior, 24(1), 36-43.
- . BMC Med Res Methodol, 11, 4.
- . Pharmacoeconomics, 29(3), 225-237.
- . Acupunct Med, 27(2), 72-75.
- . BMJ, 339, b2538.
- . Sex Transm Infect, 83(6), 441-446.
- . Statistical Methods in Medical Research.
- . Medical Decision Making.
- . PharmacoEconomics.
- . PharmacoEconomics.
- The feasibility and acceptability of an app-based intervention with brief behavioural support (APPROACH) to promote brisk walking in people diagnosed with breast, prostate, and colorectal cancer in the UK. Cancer Medicine.
- Challenges and Opportunities in Interdisciplinary Research and Real-World Data for Treatment Sequences in Health Technology Assessments. PharmacoEconomics.
- . BMC Medical Research Methodology, 24(1).
- . Bone & Joint Open, 4(11), 873-880.
- . Statistics in Medicine.
- . Medical Decision Making.
- . Clinical Rehabilitation, 026921552097534-026921552097534.
- . Journal of Public Health.
- Prevalence of Immature Survival Data for Anti-Cancer Drugs Presented to NICE and Impact on Decision-Making. Value in Health.
- Extrapolation of survival curves using standard parametric models and flexible parametric spline models: comparisons in large registry cohorts with advanced cancer. Medical Decision Making.
- . BMC Health Services Research.
Conference proceedings papers
- TESTING A SURVIVAL EXTRAPOLATION ALGORITHM FOR CANCER IMMUNOTHERAPIES: PASS OR FAIL?. VALUE IN HEALTH, Vol. 26(12) (pp S13-S13)
- COMBINING CAUSAL INFERENCE AND WITHIN-TRIAL ECONOMIC EVALUATION METHODS TO ASSESS THE COST-EFFECTIVENESS OF A MENTAL HEALTH SERVICE USING REAL-WORLD DATA: THE QUASI-EXPERIMENTAL ADAPT STUDY. VALUE IN HEALTH, Vol. 26(12) (pp S87-S87)
- ADJUSTING FOR SWITCHES TO MULTIPLE TREATMENTS IN RANDOMISED CONTROLLED TRIALS: A COMPARISON OF INVERSE PROBABILITY WEIGHTING AND TWO-STAGE ESTIMATION METHODS. VALUE IN HEALTH, Vol. 26(12) (pp S394-S394)
- EVALUATING BIAS ASSOCIATED WITH INADEQUATE VARIABLE SELECTION WHEN USING INVERSE PROBABILITY OF CENSORING WEIGHTS TO ADJUST FOR TREATMENT SWITCHES IN CLINICAL TRIALS. VALUE IN HEALTH, Vol. 26(12) (pp S423-S424)
- ACCOUNTING FOR STUDY HETEROGENEITY WHEN MODELLING THE MULTI-STATE NATURAL HISTORY OF RARE DISEASES. VALUE IN HEALTH, Vol. 26(12) (pp S421-S422)
- . Value in Health, Vol. 25(12 Suppl) (pp S461-S461). Vienna, Austria, 6 November 2022 - 9 November 2022.
- Promoting physical activity via a smartphone application in people living with breast, prostate or colorectal cancer: study protocol for a randomised pilot trial (APPROACH). PSYCHO-ONCOLOGY, Vol. 31 (pp 20-20)
- A CASE STUDY ASSESSING THE COST-EFFECTIVENESS OF MAINTENANCE IMMUNOSUPPRESSIVE THERAPY FOR KIDNEY TRANSPLANTATION IN ADULTS: ACCOUNTING FOR NON-ADHERENCE USING DATA FROM A RANDOMISED TRIAL AND THE REAL WORLD WITHIN A DECISION-ANALYTIC MODEL. VALUE IN HEALTH, Vol. 25(7) (pp S529-S529)
- A METHODOLOGICAL FRAMEWORK TO ACCOUNT FOR THE IMPACT OF NON-ADHERENCE ON THE COST-EFFECTIVENESS OF CHRONIC MEDICATIONS. VALUE IN HEALTH, Vol. 25(7) (pp S520-S520)
- Application of the Target Trial Framework for Estimating Comparative Effectiveness Using Real-World Data - A Systematic Review. VALUE IN HEALTH, Vol. 25(12) (pp S461-S461)
- ESTIMATION OF TRANSITION PROBABILITIES FOR STATE-TRANSITION MODELS: A REVIEW OF NICE APPRAISALS. VALUE IN HEALTH, Vol. 23 (pp S615-S616)
- PREVALENCE, CHARACTERISTICS AND KEY ISSUES OF MODELLING TREATMENT SEQUENCES IN HEALTH ECONOMIC EVALUATIONS: A SYSTEMATIC REVIEW OF NICE TECHNOLOGY APPRAISALS. VALUE IN HEALTH, Vol. 23 (pp S606-S606)
- ESTIMATING THE TRUE VALUE OF NEW ONCOLOGY TREATMENTS: IMPROVED TWO-STAGE ESTIMATION TO ADJUST FOR TREATMENT SWITCHING IN RANDOMISED TRIALS. MEDICAL DECISION MAKING, Vol. 40(1) (pp E294-E295)
- . Value in Health, Vol. 22 (pp S464-S464)
- . Nephrology Dialysis Transplantation, Vol. 34(Supplement_1)
- THE ASSOCIATION BETWEEN FOUR TIMES A WEEK COMPARED TO THREE TIMES A WEEK HAEMODIALYSIS AND SURVIVAL, HOSPITALISATION AND VASCULAR ACCESS COMPLICATIONS IN EUROPEAN IN-CENTRE PATIENTS. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34
- IMPACT OF USING IMMATURE SURVIVAL DATA ON NICE DECISION-MAKING. VALUE IN HEALTH, Vol. 22 (pp S464-S464)
- . Blood, Vol. 132(Supplement 1) (pp 457-457)
- . Blood, Vol. 132(Supplement 1) (pp 2712-2712)
- Adjusting the causal effects of treatments in the presence of patient non-adherence: a systematic review of methodological papers. European Society for Patient Adherence, Compliance and Persistence, Dublin, 29 November 2018 - 1 December 2018.
- . Value in Health, Vol. 21 (pp S68-S68)
- Behavioural activation therapy for depression after stroke (BEADS): a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression. INTERNATIONAL JOURNAL OF STROKE, Vol. 12 (pp 15-15)
- . Value in Health, Vol. 20(9) (pp A769-A769)
- . Value in Health, Vol. 20(9) (pp A718-A718)
- TO RE-CENSOR, OR NOT TO RE-CENSOR, THAT IS THE QUESTION: CRITICAL CONSIDERATIONS WHEN APPLYING STATISTICAL METHODS TO ADJUST FOR TREATMENT SWITCHING IN CLINICAL TRIALS. VALUE IN HEALTH, Vol. 20(5) (pp A314-A314)
- ADJUSTING FOR TREATMENT SWITCHING IN THE RELAPSING-REMITTING MULTIPLE SCLEROSIS CLARITY TRIAL AND THE CLARITY EXTENSION STUDY. VALUE IN HEALTH, Vol. 20(9) (pp A718-A718)
- . Value in Health, Vol. 19(7) (pp A398-A398)
- . Value in Health, Vol. 18(7) (pp A338-A338)
- . Journal of Clinical Oncology, Vol. 33(15_suppl) (pp e15592-e15592)
- . Value in Health, Vol. 17(7) (pp A577-A577)
- . Clinical Trials
- . VALUE IN HEALTH, Vol. 16(7) (pp A610-A611)
- . VALUE IN HEALTH, Vol. 16(7) (pp A325-A325)
- Adjusting for treatment crossover in the BREAK-3 metastatic melanoma trial for dabrafenib: Preliminary analysis. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Adjusting for treatment crossover in the METRIC metastatic melanoma (MM) trial for trametinib: Preliminary analysis. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- The importance of adjusting for treatment crossover bias in oncology clinical trials: An analysis of the EGF104900 trial in metastatic breast cancer (mBC). JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- . VALUE IN HEALTH, Vol. 15(7) (pp A462-A462)
- . VALUE IN HEALTH, Vol. 14(7) (pp A242-A242)
- Using the Liverpool Quality of Life battery to develop a health state classification system for Epilepsy. QUALITY OF LIFE RESEARCH, Vol. 19 (pp 57-57)
- EXPLORATORY ECONOMIC EVALUATION OF ADJUVANT TREATMENT OF NON-SMALL-CELL LUNG CANCER (NSCLC) WITH BEVACIZUMAB IN ADDITION TO A CISPLATIN-BASED TREATMENT REGIMEN IN THE UNITED KINGDOM. VALUE HEALTH, Vol. 11(6) (pp A357-A357)
- EXPLORATORY COST EFFECTIVENESS ANALYSIS OF BEVACIZUMAB IN ADDITION TO FOLFOX-4 IN THE ADJUVANT TREATMENT OF STAGE III COLON CANCER: A UK PERSPECTIVE. VALUE HEALTH, Vol. 11(6) (pp A471-A472)
- The cost of adults with severe active rheumatoid arthritis who do not respond to treatment following treatment with one TNF inhibitor. RHEUMATOLOGY, Vol. 47 (pp II123-II124)
- The impact of rituximab on resource use in a UKNHS rheumatology day care service. RHEUMATOLOGY, Vol. 47 (pp II119-II120)
- What are the costs of treating severe active rheumatoid arthritis with TNF inhibitors, rituximab and abatacept?. RHEUMATOLOGY, Vol. 47 (pp II122-II123)
- A cost utility analysis of peginterferon alfa-2a (40KD) versus peginterferon alfa-2b (12KD) for the treatment of chronic hepatitis C (CHC) in the UK. VALUE HEALTH, Vol. 8(6) (pp A58-A58)
Reports
- Leveraging real-world data to assess treatment sequences in health economic evaluations: a study protocol for emulating target trials using the English Cancer Registry and US Electronic Health Records-Derived Database
- Pre-read document 1: Challenges in valuing and paying for combination regimens in oncology
- Causal inference for long-term survival in randomised trials with treatment switching: Should re-censoring be applied when estimating counterfactual survival times?
- Assessing methods for dealing with treatment crossover in clinical trials: A follow-up simulation study
Scholarly editions
- Developing a health state classification system from NEWQOL for epilepsy using classical psychometric techniques and Rasch analysis: a technical report.
Posters
- Adjusting for treatment crossover in a trametinib metastatic melanoma RCT: Identifying the appropriate method.
Other
Preprints
- Teaching interests
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My teaching interests lie in the field of health economics, economic evaluation and survival analysis. I have previously co-ordinated and taught several modules on economic evaluation and survival analysis on various MSc courses. Currently, I teach methods for adjusting for treatment switching in clinical trials on the Further Statistical Methods for Health Economic Analysis module on the Health Economics and Decision Modelling MSc.
I have completed the Certificate in Learning and Teaching (PGCertHE), the University Of 91探花's professional development course in learning and teaching in higher education.
I am currently supervising five PhD students. Abu Alshreef is investigating adjustment for non-adherence in economic evaluation. Rachid Rafia is exploring multi-state models and partitioned survival models for cancer treatments. Amy Chang is researching methods for modelling the effectiveness and cost-effectiveness of treatment sequences. Ash Bullement is investigating survival analysis methods. Saleema Rex is examining the use of causal inference methods to estimate comparative effectiveness using registry datasets.
I am interested in supervising potential students on topics around adjustment for treatment switching in clinical trials, and the use of causal inference methods to estimate comparative effectiveness from observational datasets.
- Professional activities and memberships
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I have pursued my research interests through a series of research fellowships. In 2012 I completed an NIHR Doctoral Research Fellowship, and in 2018 I completed an NIHR Post-Doctoral Research Fellowship. My current 5-year Yorkshire Cancer Research Fellowship began in January 2019. I also contribute to several other research and consultancy projects in ScHARR.
- I am a member of NICE Technology Appraisal Committee B
- I have been a member of the Yorkshire and Humber Research for Patient benefit Programme Regional Advisory committee
- I am a member of the Health Economists Study Group
- I am a Fellow of the Higher Education Academy
- I have been an invited expert for the NICE Scientific Advice Programme.
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