Dr Munya Dimairo
BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)
Population Health, School of Medicine and Population Health
Senior Research Fellow/ Statistician
+44 114 222 5204
Full contact details
Population Health, School of Medicine and Population Health
Room 2029
Regent Court (ScHARR)
30 Regent Street
91探花
S1 4DA
- Profile
-
Munya leads statistical support in the design, conduct, monitoring, analysis, and reporting of studies (mostly clinical trials) within the University of 91探花 Clinical Trials Research Unit (CTRU). This includes overseeing multiple projects that are at various stages to ensure high-quality delivery. He also supports research proposal development of research for funding. In addition, Munya leads and collaborates on methodological research aimed at improving efficiency in the conduct of trials as well as the implementation of innovative and efficient designs within the unit, such as adaptive trial designs. His vast research interests are around innovative clinical trials statistical methodology and their translation into routine practice. He serves as an independent statistician on trial steering and data monitoring committees of several publicly funded clinical trials.
Munya holds a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine (funded by Wellcome Trust), and a in Medical Statistics from the University of 91探花 (funded by the NIHR, DRF-2012-05-182). His PhD investigated the utility of adaptive designs in publicly funded confirmatory trials.
Munya is based in the Design, Trials and Statistics (DTS) section within ScHARR.
- Qualifications
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BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)
- Research interests
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- Clinical trials methodology
- Adaptive designs, especially group sequential methods and treatment selection in multi-arm and platform trials
- Transparency and reporting of adaptive trials
- Statistical issues around the application of a stepped wedge trial design
- Bayesian inference and borrowing of information in clinical trials
- Early phase clinical trials
- Diagnostic accuracy studies
- Hierarchical or Multilevel modelling
- Multiple imputation techniques in dealing with missing data
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . BMC Medical Research Methodology, 24(1).
- . BMJ Open, 14(1), e076434-e076434.
- . BMJ, 383, e076387.
- . BMJ, 383, e076386.
- . BMC Medicine, 21(1), 246.
- . Statistics in Medicine.
- . BMJ Open, 13.
- . Statistics in Medicine.
- . BMC Medicine, 20(1).
- . Health Technology Assessment, 26(10), 1-211.
- . Nature Medicine, 28(1), 6-7.
- . BMC Medicine, 19(1).
- . Human Reproduction, 36(7), 1841-1853.
- . Clinical Rehabilitation.
- . Trials, 21(1).
- . BMJ, 369.
- . Health Technology Assessment, 24(19), 1-176.
- . The Lancet Neurology, 18(9), 821-833.
- . JNCI: Journal of the National Cancer Institute.
- . Journal of Clinical Epidemiology.
- . BMC Medicine, 16.
- . BMC Medical Research Methodology, 18(1), 105-105.
- . BMC Medicine, 16.
- . Health Technology Assessment, 21(20), 1-278.
- . BMJ, 356.
- . BMJ Open, 7(e013537).
- . BMC Medical Research Methodology, 16.
- . Trials, 17(1).
- . Trials, 16(1).
- . Trials, 16(1).
- . Trials, 15(1), 264-264.
- . Health Technol Assess, 18(13), 1-210.
- . International Journal of Tuberculosis and Lung Disease, 15(10), 1390-1396.
- . Pediatr Infect Dis J, 29(4), 346-351.
- . PLoS ONE, 5(7).
- Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.. Int J Tuberc Lung Dis, 13(10), 1253-1259.
- . Stroke.
- . PLOS ONE, 10(11), e0141104-e0141104.
Conference proceedings papers
- Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017.
- Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017.
- . Trials, Vol. 16(S2)
- . Trials, Vol. 16(S2)
- Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015.
- . Trials, Vol. 12 Suppl 1 (pp A26)
- The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada
- Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011.
Website content
Posters
- Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research.
- Methods to analyse partially nested randomised controlled trials.
Theses / Dissertations
All publications
Journal articles
- . BMC Medical Research Methodology, 24(1).
- . BMJ Open, 14(3).
- . BMJ Open, 14(1), e076434-e076434.
- . British Journal of Anaesthesia.
- . BMJ, 383, e076387.
- . BMJ, 383, e076386.
- . British Journal of Dermatology, 189(3), e42-e43.
- . BMC Medicine, 21(1), 246.
- . Statistics in Medicine.
- . BMJ Open, 13.
- . Statistics in Medicine.
- . BMC Medicine, 20(1).
- . Health Technology Assessment, 26(10), 1-211.
- . Nature Medicine, 28(1), 6-7.
- . BMC Medicine, 19(1).
- . Human Reproduction, 36(7), 1841-1853.
- . Clinical Rehabilitation.
- . Colorectal Disease.
- . Trials, 21(1).
- . BMJ, 369.
- . Health Technology Assessment, 24(19), 1-176.
- . The Lancet Neurology, 18(9), 821-833.
- . JNCI: Journal of the National Cancer Institute.
- . Journal of Clinical Epidemiology.
- . BMC Medicine, 16.
- . BMC Medical Research Methodology, 18(1), 105-105.
- . BMJ Open, 8(4).
- . BMC Medicine, 16.
- . European Spine Journal, 22(3).
- . Health Technology Assessment, 21(20), 1-278.
- . BMJ, 356.
- . BMJ Open, 7(e013537).
- . BMC Medical Research Methodology, 16.
- . Trials, 17(1).
- . Diabetic Medicine, 33(2), 243-251.
- . Trials, 16(1).
- . Trials, 16(1).
- . Trials, 15(1), 264-264.
- . Health Technol Assess, 18(13), 1-210.
- . Trials, 14(Suppl 1), 46.
- Discussion on the paper by Hampson and Jennison. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 75(1), 40-54.
- . BMJ Open, 3(10), e003509.
- . Trials, 14(Suppl 1), O21.
- . Stroke, 43(7), 1904-1911.
- . Trials, 12, 259.
- . BMC Public Health, 11, 129.
- . International Journal of Tuberculosis and Lung Disease, 15(10), 1390-1396.
- . Pediatr Infect Dis J, 29(4), 346-351.
- . PLoS ONE, 5(7).
- Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.. Int J Tuberc Lung Dis, 13(10), 1253-1259.
- . Stroke.
- . PLOS ONE, 10(11), e0141104-e0141104.
Conference proceedings papers
- Endometrial scratching in women undergoing their first In Vitro Fertilisation (IVF) cycle: results from the UK Multicentre Endometrial Scratch Randomised Controlled Trial. HUMAN REPRODUCTION, Vol. 35 (pp 140-141)
- . Trials, Vol. 20(Supplement 1) (pp 2-3). Brighton, UK, 6 October 2019 - 9 October 2019.
- Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017.
- Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017.
- . BMC Health Services Research, Vol. 16(1)
- . Trials, Vol. 16(S2)
- . Trials, Vol. 16(S2)
- Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015.
- . Trials, Vol. 12 Suppl 1 (pp A26)
- . BONE, Vol. 48(1) (pp S17-S17)
- The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada
- Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011.
- Evaluation of a Commercial Urine Lipoarabinomannan ELISA Kit for Diagnosis of TB in a High HIV Prevalence Setting. 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada, 8 February 2009 - 11 February 2011.
Website content
Posters
- Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research.
- Methods to analyse partially nested randomised controlled trials.
Theses / Dissertations
Datasets
Preprints
- Confidence intervals for adaptive trial designs II: Case study and practical guidance, arXiv.
- Confidence intervals for adaptive trial designs I: A methodological review, arXiv.
- , Center for Open Science.
- , arXiv.
- , ScienceOpen.
- Point estimation for adaptive trial designs.
- Point estimation for adaptive trial designs, arXiv.
- , Research Square.
- , Center for Open Science.
- Grants
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- Accelerating the development of a perinatal platform trial to efficiently evaluate the effectiveness of multiple interventions in maternity and neonatal care. NIHR (NIHR156043). Co-applicant. 拢199,592
- NIHR Pre-Doctoral Fellowship Award for Isabelle Wilson. NIHRC (NIHR302738). Co-applicant and Lead Supervisor. 拢66,757
- Diversity and inclusion in early phase trials. Research England. Co-applicant. 拢22.910
- Efficacy and mechanism evaluation of transcutaneous vagal nerve stimulation for upper limb recovery post-stroke 鈥 a randomised, controlled, multi-arm, multi-stage, adaptive design trial. NIHR (NIHR133169). Co-applicant. 拢1,704,864.
- Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa (MissionEB). NIHR (NIHR127963). Co-applicant. 拢2,451,255.
- MICA: Early Phase Dose-finding Trials: Development of reporting guidance to improve knowledge transfer. MRC (MR/T044934/1). Co-applicant. 拢306,579.
- STOP-OHSS (Shaping and Trialling Outpatient Protocols for Ovarian Hyper-Stimulation Syndrome): A feasibility study and randomised controlled trial, with internal pilot, to assess the clinical and cost-effectiveness of earlier active management of OHSS. NIHR HTA (NIHR128137). Co-applicant. 拢1,782,753.
- A Practical Adaptive & Novel Design and Analysis (PANDA) toolkit. NIHR CTU Support Funding (NIHR129761). Lead Investigator. 拢98,886.
- Costing Adaptive Trials (CAT): developing best practice costing guidance for CTUs supporting adaptive trials. NIHR CTU Support Funding (NIHR130351). Co-applicant. 拢55,629.
- Development of CONSORT guidance for adaptive clinical trials. NIHR CTU Support Funding (NIHR129671) and MRC HTMR (MR/L004933/1-R/N/P/B1). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers. 拢63,000.
- Utility of adaptive designs in publicly funded trials. NIHR Doctoral Research Fellowship (DRF-2012-05-182). Lead investigator. 拢206,221.
- NHS England Specialised Commissioning 鈥 NIHR 2018 Funding Call for CTUs. Co-applicant. 拢13 961.
- Outcome Measures for Emergency Care after a Seizure (OMECS): NIHR CTU Support Funding. (NIHR129743). Co-applicant. 拢9,852.
- Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. NIHR RfPB (PB-PG-0110-21158). Co-applicant. 拢197,129.
- Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) 鈥 A randomised controlled pilot trial. CLAHRC South Yorkshire. Co-applicant. 拢28,170.
- Masters Fellowship in Public Health and Tropical Medicine at LSHTM. Wellcome Trust (085840/Z/08/Z). Lead Investigator. 拢75,919.
- Teaching interests
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Supervision of postgraduate research students in areas around trials and statistical methods.
- Professional activities and memberships
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- Trials Associate Editor
- Member of the BMC Medicine Editorial Board
- Member of the Research Square Advisory Board
- Member of the ICTMC Scientific Committee
- Member of the MRC/NIHR TMRP ADWG
- Advisory board member of The Bill & Melinda Gates Foundation on adaptive trials in low- and middle-income countries
- Reviewer of grant proposals for publicly funding bodies such as NIHR and MRC
- Independent Trial Statistician on trial steering and data monitoring committees
- Independent statistical reviewer for several journals including the BMJ, The Lancet, and The Lancet Infectious Diseases
- Member of the NIHR HTA CET Funding Committee