Professor Stephen A Renshaw
MA FRCP PhD
Clinical Medicine, School of Medicine and Population Health
Head of Division of Clinical Medicine
Deputy Dean of School of Medicine and Population Health
Sir Arthur Hall Professor of Medicine
+44 114 2159574
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room FU19, F Floor
The Medical School
Beech Hill Road
91探花
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I have worked for the University of 91探花 since 1998. I am the Sir Arthur Hall Professor of Medicine and Director of the Bateson Centre - a large cross-faculty research centre (former MRC Centre, 40PIs, over 130 members and active grant funding of over 拢30m).
I have held important leadership roles in large cross-institution partnerships, including being founding director of an MRC Doctoral Training Partnership across 4 major civic universities of the North of England 鈥 highly regarded as a model for student-led, cross-institutional, innovative postgraduate research training. I also have national and International leadership roles through membership of REF 2021 sub-panel 1, and having been principal organiser of Neutrophil 2021 and the Zebrafish Disease Models meeting 2022.
I studied medicine at Cambridge and then at Oxford Clinical School. After a clinical rotation in Nottingham, I moved to 91探花 to take up a Wellcome Trust Clinical Research Training Fellowship, to work on the regulation of neutrophil lifespan with Professor Moira Whyte.
After 3 years as Clinical Lecturer in Respiratory Medicine, I was awarded an MRC Clinician Scientist Fellowship to develop an innovative model of neutrophil biology in the transparent, genetically-tractable larval zebrafish. I have been able to develop a number of unique transgenic zebrafish which have allowed several important advances in our understanding of inflammation biology and of host-pathogen interaction.
In 2008 I was awarded an MRC Senior Clinical Fellowship and in 2014 an MRC Programme Grant to continue this work. I continue clinical work in Respiratory Medicine with a special interest in Interstitial Lung Disease associated with a range of multisystem diseases.
- Research interests
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Diseases of immunity cause much illness in the developed world 鈥 on one hand we are beset by a range of antibiotic resistance bacterial infections, while on the other hand our immune systems are responsible for many the common diseases of ageing 鈥 heart disease, stroke and COPD.
Understanding the regulation of innate immune cells, neutrophils and macrophages, in infection and inflammation will help us tune the immune system to the exact level needed to cope with the current level of threat. More host defence to fight antibiotic-resistant organisms; less host defence to prevent lung damage in response to environmental pollutants.
To improve our understanding, I have set up a model system in which the genes controlling regulation of innate immune cell function can be identified. The model I have chosen is the Zebrafish, which is both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation.
This model allows me to test the ability of a range of candidate genes to influence host-pathogen interaction and the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an infection or an inflammatory episode, where necessary imaging intracellular signalling events in real-time.
The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease.
Current projects
- Identification of key regulatory pathways in inflammation resolution.
- Non-mammalian models of host-pathogen interaction.
- Identification of novel compounds targeting inflammation resolution using zebrafish in vivo screens.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . PLoS Pathogens, 18(4).
- . Proceedings of the National Academy of Sciences, 118(44).
- . PLoS Pathogens, 17(9).
- . eLife, 10.
- . PLoS Pathogens, 17(3).
- . Journal of Cell Science, 134(5).
- . Frontiers in Immunology, 11(1).
- . Autophagy.
- . ACS Nano.
- . Glia.
- . Journal of Clinical Investigation.
- . Autophagy.
- . eLife, 8.
- . Frontiers in Immunology, 10.
- . PLoS Pathogens, 15(3).
- . Cell Reports, 26(7), 1828-1840.e4.
- . Science Advances, 4(9).
- . Nature Microbiology, 3(8), 881-890.
- . Trends in Immunology, 37(5), 273-286.
- . Science, 346(6209), 641-646.
- . PLoS Biol, 12(5), e1001855.
- . Dev Comp Immunol, 46(1), 53-62.
- . PLoS Pathog, 10(2), e1003959.
- . Sci Transl Med, 6(225), 225ra29.
- . J Immunol, 192(4), 1796-1805.
- . Dis Model Mech, 7(2), 259-264.
- . PLoS Pathog, 9(12), e1003789.
- . J Leukoc Biol, 94(4), 633-642.
- . Current Biology, 22(19), 1818-1824.
- . J R Soc Interface, 9(77), 3229-3239.
- . Cell Microbiol, 14(10), 1600-1619.
- . Thorax, 67(9), 796-803.
- Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE 2. Current Biology.
- . Dis Model Mech, 5(1), 38-47.
- . Blood, 118(3), 712-722.
- . Thromb Haemost, 105(5), 811-819.
- . J Leukoc Biol, 87(2), 203-212.
- . Cell Microbiol, 10(11), 2312-2325.
- . Nat Rev Immunol, 7(1), 77-82.
- . Blood, 108(13), 3976-3978.
- . J Immunol, 170(2), 1027-1033.
All publications
Journal articles
- . Current Microbiology, 81(12).
- . Journal of Cystic Fibrosis, 23, S30-S30.
- . Journal of Cystic Fibrosis, 23, S132-S133.
- . Proceedings of the National Academy of Sciences, 121(21).
- . Fish & Shellfish Immunology, 148, 109490-109490.
- . Journal of Cystic Fibrosis, 22, S137-S137.
- . Aging Cell.
- . Scientific Reports, 13(1), 1-11.
- . The Lancet, 400(10349), 359-368.
- . Immunity & Ageing, 19(1).
- . Cellular Microbiology, 2022, 1-13.
- . PLoS Pathogens, 18(4).
- . Disease Models & Mechanisms.
- . The Lancet, 399(10325), 665-676.
- . The Lancet, 399(10320), 143-151.
- . Proceedings of the National Academy of Sciences, 118(44).
- . PLoS Pathogens, 17(9).
- . eLife, 10.
- . The Lancet, 397(10285), 1637-1645.
- . The Lancet, 397(10289), 2049-2059.
- . PLoS Pathogens, 17(3).
- . Journal of Cell Science, 134(5).
- . The Lancet, 397(10274), 605-612.
- . Frontiers in Immunology, 11(1).
- . Sarcoidosis Vasculitis and Diffuse Lung Diseases, 37(2), 218-224.
- . Autophagy.
- . ACS Nano.
- . Frontiers in Immunology, 11.
- . Glia.
- . Journal of Clinical Investigation.
- . Autophagy.
- . BMJ Open Respiratory Research, 6(1), e000469-e000469.
- . Open Forum Infectious Diseases, 6(Supplement_2), S904-S904.
- . Journal of Controlled Release, 314, 116-124.
- . eLife, 8.
- . Frontiers in Immunology, 10.
- . PLoS ONE.
- . Thorax, 74(5), 500-502.
- . PLoS Pathogens, 15(3).
- . Cell Reports, 26(7), 1828-1840.e4.
- . The Journal of Immunology, 202(2), 494-502.
- . Microbiology, 165(4), 367-385.
- . Science Advances, 4(9).
- . Nature Microbiology, 3(8), 881-890.
- . F1000Research, 7, 594-594.
- . Methods Mol Biol, 1736, 147-156.
- . FEBS Journal.
- . Infection and immunity, 85(11).
- . PLoS Pathogens, 13(7).
- . Scientific Reports, 7.
- . Blood, 130, 1014-1025.
- . Journal of Immunology.
- . The FEBS Journal, 284(3), 399-401.
- . Scientific Reports, 6.
- . DMM Disease Models and Mechanisms, 9, 621-632.
- . Trends in Immunology, 37(5), 273-286.
- . Scientific Reports, 6(1), 21489-21489.
- . Journal of Leukocyte Biology, 98(6), 975-981.
- . Human Molecular Genetics, 24(23), 6640-6652.
- . Disease Models & Mechanisms, 8(11), 1349-1360.
- . Diabetes, 64(8), 2991-2995.
- . EMBO Molecular Medicine, 7(2), 127-139.
- Investigating the role of a prototype GIMAP in neutrophil regulation using an in vivo zebrafish model. IMMUNOLOGY, 143, 113-114.
- . Science, 346(6209), 641-646.
- . ACS Nano, 8(5), 4650-4661.
- Hypoxic signalling modulates neutrophil nitric oxide in a zebrafish tuberculosis model. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 12-12.
- . PLoS Biol, 12(5), e1001855.
- . Dev Comp Immunol, 46(1), 53-62.
- . PLoS Pathog, 10(2), e1003959.
- . Sci Transl Med, 6(225), 225ra29.
- . J Immunol, 192(4), 1796-1805.
- . Dis Model Mech, 7(2), 259-264.
- . Dis Model Mech, 7(1), 163-169.
- . PLoS Pathog, 9(12), e1003789.
- . Infect Immun, 81(11), 4271-4279.
- . JOURNAL OF IMMUNOLOGY, 190(8), 4349-4359.
- . BLOOD, 121(13), 2483-2493.
- . J Leukoc Biol, 94(4), 633-642.
- . J Sleep Res, 22(4), 471-477.
- . PLoS One, 8(8), e72636.
- . Blood, 123(3), 366-376.
- . FASEB J, 27(1), 98-108.
- . Current Biology, 22(19), 1818-1824.
- . J R Soc Interface, 9(77), 3229-3239.
- . Cell Microbiol, 14(10), 1600-1619.
- . Cancer Res, 72(16), 4017-4027.
- . PLoS ONE, 7(4).
- . Thorax, 67(9), 796-803.
- . ISRN Hematol, 2012, 915868.
- . Adv Hematol, 2012, 792163.
- Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE 2. Current Biology.
- . Dis Model Mech, 5(1), 38-47.
- . J CELL SCI, 124(18), 3053-3059.
- . Blood, 118(3), 712-722.
- . J Leukoc Biol, 90(5), 855-865.
- . Thromb Haemost, 105(5), 811-819.
- . B36. AIRWAY IMMUNE MECHANISMS AND INFLAMMATION: ANIMAL MODELS.
- . Haematologica, 96(12), 1753-1760.
- . PLoS One, 6(1), e15810.
- . PLoS One, 6(1), e15768.
- . INFECT IMMUN, 78(4), 1495-1508.
- . J Leukoc Biol, 87(2), 203-212.
- . BMC Biol, 8, 148.
- . GASTROENTEROLOGY, 137(5), 1757-1767.
- . Biochem Soc Trans, 37(Pt 4), 830-837.
- . Immunology, 127(2), 249-255.
- Using Transgenic Zebrafish To Screen for Small Molecules That Promote Resolution of Neutrophilic Inflammation.. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
- . Cell Microbiol, 10(11), 2312-2325.
- Evolution of the inflammatory response in vertebrates: Fish TNF-alpha is a powerful activator of endothelial cells but hardly activates phagocytes. J IMMUNOL, 181(7), 5071-5081.
- . Exp Lung Res, 33(10), 549-554.
- . J Biol Chem, 282(48), 35202-35210.
- . Nat Rev Immunol, 7(1), 77-82.
- . Blood, 108(13), 3976-3978.
- . Clin Sci (Lond), 110(3), 293-304.
- . FEBS Lett, 579(17), 3646-3650.
- . J Biol Chem, 279(4), 2846-2855.
- . Clinical Science, 104(s49), 58P-58P.
- . J Immunol, 170(2), 1027-1033.
- . Clinical Science, 103(s47), 54P-54P.
- . Clinical Science, 101(s45), 2P-2P.
- . J Leukoc Biol, 67(5), 662-668.
- . Biochem Soc Trans, 27(6), 802-807.
- . Biochemical Society Transactions, 27(5), A134-A134.
- . mBio.
- . Nature Communications, 15(1).
- . Aging Cell.
- . Critical Reviews in Microbiology, 1-16.
- . Disease Models & Mechanisms.
- . The Lancet.
- . Disease Models & Mechanisms.
- . Frontiers in Immunology, 13.
- . American Journal of Respiratory Cell and Molecular Biology.
- . PLOS Pathogens, 16(11), e1009058-e1009058.
- . PLOS ONE, 15(10), e0240231-e0240231.
- . Frontiers in Immunology, 11.
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- Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast enhanced perfusion MRI. Thorax.
Chapters
Conference proceedings papers
- . 鈥楿nder your skin鈥 鈥 imaging in lung disease
- . Imaging
- . Imaging
- . A62. MUCUS, MUCINS, MUCOCILIARY UNIT IN LUNG DISEASE
- The role of augmenting material in Staphylococcus aureus interaction with macrophages. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol. 49 (pp 205-205)
- Neutrophils activated with Hif-1 alpha are protective in zebrafish tuberculosis in vivo models. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol. 49 (pp 67-68)
- Lc3-associated phagocytosis provides an intracellular niche for Staphylococcus aureus in neutrophils. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol. 49 (pp 203-204)
- . Thorax, Vol. 73(Suppl 4) (pp A44-A45). London, UK, 5 December 2018 - 7 December 2018.
- . IFAC-PapersOnLine, Vol. 51(15) (pp 766-771), 9 July 2018 - 11 July 2018.
- . Journal of Cystic Fibrosis, Vol. 17(S3) (pp 58-59), 6 June 2018 - 9 June 2018.
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Evaluation of Perfusion Heterogeneity in Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- . European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 13 September 2017.
- Synthesis of novel tanshinones for probing the inflammatory response in zebrafish. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 254
- Polymersomes for targeting and eradicating intracellular parasites. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 253
- . Journal of Infection, Vol. 71(6) (pp 684-684)
- . Annals of the Rheumatic Diseases, Vol. 74(Suppl 2) (pp 833.1-833)
- Hypoxia signaling modulates neutrophil nitric oxide in a zebrafish tuberculosis model. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- . THORAX, Vol. 68 (pp A108-A109)
- . 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 3 July 2013 - 7 July 2013.
- A Bayesian framework for identifying cell migration dynamics. 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) (pp 3459-3462)
- . THORAX, Vol. 67 (pp A1-A1)
- . THORAX, Vol. 67 (pp A171-A172)
- Exploring neutrophil behaviour in a zebrafish model of inflammation through the generation of novel parameters using MatLab algorithms. IMMUNOLOGY, Vol. 137 (pp 254-254)
- Assessment of exercise capacity following continuous positive airway pressure therapy in patients with obstructive sleep apnoea/hypopnoea syndrome using the incremental shuttle walk test (ISWT). JOURNAL OF SLEEP RESEARCH, Vol. 21 (pp 347-347)
- Macrophage-delivered signals drive inflammation resolution in an in vivo zebrafish model. IMMUNOLOGY, Vol. 137 (pp 255-255)
- . C31. REGULATION OF LUNG INFLAMMATION
- Local affine texture tracking for serial registration of zebrafish images.. ISBI (pp 434-437)
- . THORAX, Vol. 65 (pp A56-A56)
- Wiskott Aldrich syndrome protein knockdown enhances collateral vessel formation in zebrafish. EUROPEAN HEART JOURNAL, Vol. 31 (pp 622-622)
- . THORAX, Vol. 64 (pp A42-A43)
- Using transgenic zebrafish models to help understand inflammatory lung disease. THORAX, Vol. 62 (pp A116-A117)
- Lentivirus: A tool for the study of neutrophil biology. JOURNAL OF LEUKOCYTE BIOLOGY (pp 36-36)
- Regulation of granulocyte apoptosis by 3 novel isoforms of the BCL-2 protein, Bid. THORAX, Vol. 58 (pp 31-31)
Preprints
- , Research Square Platform LLC.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
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- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Professional activities and memberships
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- Director, The Bateson Centre.
- REMOVE Director, MRC Doctoral Training Partnership, Discovery Medicine North.
- Deputy Director and 91探花 Lead, MRC SHIELD Antimicrobial Research Consortium.
- REMOVE MRC Programme Grant Holder.
- REMOVE: Current sponsor of 3 Wellcome Trust/Royal Society Sir Henry Dale Fellows, 1 Wellcome Trust Clinical Training Fellow and 1 European Leukodystrophy Association Fellow.
- Remove: Board Member and co-chair of the Trainee Programme, Zebrafish Disease Models Society.
- Principal Organiser, Neutrophil in Immunity Meeting 2021 and Zebrafish Disease Models meeting 2022.
- Research Excellence Framework, subpanel 1.