Thompson, Ruth, Dr

Dr Ruth Thompson

Clinical Medicine, School of Medicine and Population Health

Royal Society Dorothy Hodgkin Research Fellow

R.H.Thompson@91̽��.ac.uk
+44 114 215 9235

GU34, The Medical School

Full contact details

Dr Ruth Thompson
Clinical Medicine, School of Medicine and Population Health
GU34
The Medical School
Beech Hill Road
91̽��
S10 2RX

Profile

For enquiries, please contact - iicd-om-operational@sheffield.ac.uk

2018 - present
Royal Society Dorothy Hodgkin Research Fellow
School of Medicieneand Popuoation Health, University of 91̽��, 91̽��, UK.

2016 - 2018
JG Graves Academic Fellow
Unit of Molecular Oncology, University of 91̽��, 91̽��, UK.

2013 - 2015
Post-doctoral Researcher
Division of Haematology and Medical Oncology, Mount Sinai Hospital, New York, USA.

2010 - 2013
Post-doctoral Researcher
Geisel School of Medicine, Dartmouth College, New Hampshire, USA.

2006 - 2010
PhD
YCR Institute for Cancer Studies, University of 91̽��, 91̽��, UK.

2003 - 2006
BSc
Genetics, University of 91̽��, 91̽��, UK.

Current PhD Opportunities

Research interests

It is commonly understood that DNA damage is largely sensed and repaired in interphase and it is proposed that DNA repair is largely repressed during mitosis due to the risk of telomere fusion.

Cancer treatments such as chemo and radiotherapy induce massive amounts of DNA damage leading to cell death of rapidly dividing cells. Some cancers have developed resistance to these agents by repairing the damage prior to cell division. For this reason, drugs which target the well-known interphase DNA repair pathways are rapidly being developed for use in the clinic. Drugs such as these could be substantially less effective if there was also a DNA damage checkpoint in mitosis.

The aim of my research is to understand what happens when a cell with damaged DNA arrives in mitosis due to dysfunctional interphase checkpoints. I want to understand which signalling proteins are involved and hope to discover the mechanism by which DNA damage is sensed and targeted for repair in mitosis.

Understanding and inhibiting this pathway could lead to sensitization of tumours to standard cancer agents and thus represents a novel site of therapeutic intervention.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Liu PH, Shah RB, Li Y, Arora A, Ung PM-U, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V , Barbaro JM et al (2019) . Nature Cell Biology, 21(2), 203-213.
Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A , Sidi S et al (2017) . The Journal of Cell Biology, 216(6), 1795-1810.
Shah RB, Thompson R & Sidi S (2016) . Molecular & Cellular Oncology, 3(3), e1059921-e1059921.
Sakurikar N, Thompson R, Montano R & Eastman A (2015) . Oncotarget, 7(2), 1380-1394.
Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK & Sidi S (2015) . Molecular Cell, 58(5), 767-779.
Gagou ME, Ganesh A, Thompson R, Phear G, Sanders CM & Meuth M (2011) . Cancer Research, 71, 4998-5008.
Thompson R () . International Journal of Oncology.
Thompson R, Montano R & Eastman A () . PLoS ONE, 7(8), e44021-e44021.

All publications

Journal articles

Watson S, Porter H, Sudbery I & Thompson R (2024) . International Journal of Molecular Sciences, 25(9).
Shah RB, Kernan JL, van Hoogstraten A, Ando K, Li Y, Belcher AL, Mininger I, Bussenault AM, Raman R, Ramanagoudr-Bhojappa R , Huang TT et al (2021) . Developmental Cell, 56(15), 2207-2222.e7.
Harrision D, Gravells P, Thompson R & Bryant HE (2020) . Frontiers in Molecular Biosciences, 7.
Thompson R, Gatenby R & Sidi S (2019) . Cells, 8(9).
Liu PH, Shah RB, Li Y, Arora A, Ung PM-U, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V , Barbaro JM et al (2019) . Nature Cell Biology, 21(2), 203-213.
Thompson R & Patel P (2017) . British Journal of Hospital Medicine, 78(5), C74-C77.
Thompson R & Patel P (2017) . British Journal of Hospital Medicine, 78(5), C78-C80.
Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A , Sidi S et al (2017) . The Journal of Cell Biology, 216(6), 1795-1810.
Shah RB, Thompson R & Sidi S (2016) . Molecular & Cellular Oncology, 3(3), e1059921-e1059921.
Sakurikar N, Thompson R, Montano R & Eastman A (2015) . Oncotarget, 7(2), 1380-1394.
Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK & Sidi S (2015) . Molecular Cell, 58(5), 767-779.
Montano R, Thompson R, Chung I, Hou H, Khan N & Eastman A (2013) . BMC Cancer, 13(1).
Thompson R & Eastman A (2013) . British Journal of Clinical Pharmacology, 76(3), 358-369.
Eastman A, Montano R, Thompson R, Khan N, Hou H, Lewis LD, Seigne JD & Ernstoff MS (2013) . Cancer Research, 73(8_Supplement), 3413-3413.
Gagou ME, Ganesh A, Thompson R, Phear G, Sanders CM & Meuth M (2011) . Cancer Research, 71, 4998-5008.
Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN () . mBio.
Thompson R () . International Journal of Oncology.
Thompson R, Montano R & Eastman A () . PLoS ONE, 7(8), e44021-e44021.

Preprints

Watson S, Porter H, Sudbery I & Thompson R (2022) , Cold Spring Harbor Laboratory.
Gatenby R, Li N, Lata P, Walne T, Tufail A, Breitweiser A & Thompson R (2022) , Cold Spring Harbor Laboratory.