Dr Roger Thompson
MB ChB BSc MRCP(UK) PhD
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Respiratory Medicine
Honorary Consultant in Respiratory Medicine
+44 114 215 9558
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91探花
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I moved to 91探花 in 2006 to take up an NIHR Academic Clinical Fellowship in Respiratory Medicine having completed my undergraduate training and a medical rotation in Edinburgh. I completed an MRC Training Fellowship and PhD in 2012 under the supervision of Professor Moira Whyte and Dr Sarah Walmsley before finishing my specialist clinical training as an NIHR Clinical Lecturer.
In 2016, I was appointed as a JG Graves Fellow and an Honorary Consultant in Respiratory Medicine at 91探花 Teaching Hospitals NHS Foundation Trust. For 12 months from September 2017 I was a BHF-Fulbright scholar () in Professor Marlene Rabinovitch鈥檚 lab at Stanford University and returned to 91探花 in 2018 as a BHF Intermediate Clinical Fellow. I am now a Senior Clinical Lecturer in Respiratory Medicine.
- Research interests
-
Hypoxia has been the general theme of my research interests. In 2001 and 2003 I organised two successful high altitude research expeditions to Bolivia, focusing on maladaptive responses to hypoxia that can result in altitude illness (). During my PhD, I broadened my interests into the field of cell biology, specifically the role of HIF-2alpha in neutrophilic inflammation. I also worked on host pathogen interactions in hypoxia and demonstrated that ambient hypoxia adversely altered the host response to a limited bacterial challenge, provoking a profound phenotype of systemic illness including cardiovascular dysfunction.
Aligning my research interests with my clinical interest in pulmonary arterial hypertension (a devastating disease characterised by progressive remodelling of pulmonary blood vessels), my postdoctoral research has focussed on the role of inflammation and hypoxia in this condition. In collaboration with Laszlo Farkas (VCU), we showed that deficiency of the pattern recognition receptor (TLR3) exacerbated pulmonary hypertension, while activating TLR3 (using synthetic double-stranded RNA) reduced the severity of pulmonary hypertension in animal models of the disease. Current work aims to dissect the mechanisms by which double-stranded RNA regulates pulmonary vascular remodelling.
During the Covid-19 pandemic, I became interested in the clinical application of advanced imaging techniques for lung disease, and I participated in several multi-centre studies investigating the mechanisms of breathlessness in post-Covid patients. In ongoing work with the POLARIS group, the potential role of this technology in pulmonary vascular diseases will be explored.
Current projects
- Hypoxic modulation of host responses to infection.
- Regulation of pulmonary vascular remodelling by endogenous double stranded RNA.
- Multinuclear MR imaging to phenotype pulmonary vascular diseases.
- STH Observational Study of Patients with Pulmonary Hypertension, Cardiovascular and other Respiratory Diseases (STH-ObS) (Research Tissue Bank, Chief Investigator).
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . Magnetic Resonance in Medicine.
- . Nature Immunology, 25(4), 607-621.
- . European Respiratory Journal, 63(3).
- . Journal of the American Heart Association, 13(6).
- . npj Digital Medicine, 6.
- . European Respiratory Journal, 62(2).
- . Chest.
- . iScience, 26(2).
- . The Lancet Respiratory Medicine.
- . The Lancet Respiratory Medicine.
- . American Journal of Respiratory and Critical Care Medicine.
- . Frontiers in Physiology, 13.
- . Nature Communications, 12.
- . The Lancet, 398(10296), 223-237.
- . Arteriosclerosis, thrombosis, and vascular biology, 41(1), 430-445.
- . The European respiratory journal, 55(6).
- . International Journal of Molecular Sciences, 21(9).
- . Nature Communications, 10(1).
- . Elife, 8.
- . Frontiers in Medicine, 6.
- . American Journal of Respiratory and Critical Care Medicine, 199(2).
- . Frontiers in Medicine, 5.
- . Science Immunology, 2(8).
- . Trends in Molecular Medicine, 23(1), 31-45.
- . Nature, 522(7556), 349-353.
- . Blood, 123(3), 366-376.
All publications
Journal articles
- . Magnetic Resonance in Medicine.
- . The Journal of Heart and Lung Transplantation, 43(10), 1629-1639.
- . The Lancet Psychiatry.
- . European Respiratory Journal, 2301742-2301742.
- . Pulmonary Circulation, 14(3).
- . Magnetic Resonance in Medicine.
- . Nature Immunology, 25(4), 607-621.
- . ERJ Open Research, 10(4), 00982-2023.
- . Pulmonary Circulation, 14(1).
- . European Respiratory Journal, 63(3).
- . Journal of the American Heart Association, 13(6).
- . Radiology, 310(2).
- . Immunity & Ageing, 21.
- . BMJ Open, 14(1).
- . Brain Communications, 6(1).
- . npj Digital Medicine, 6.
- . Nature Communications, 14(1), 8487.
- . The Lancet Respiratory Medicine, 11(11), e93-e94.
- . The Lancet Respiratory Medicine.
- . European Respiratory Journal, 62(2).
- . The Lancet Regional Health - Europe, 100635-100635.
- . Frontiers in Cardiovascular Medicine, 10.
- . The Lancet Respiratory Medicine.
- . Chest.
- . eClinicalMedicine, 57, 101896-101896.
- . Journal of Magnetic Resonance Imaging.
- . iScience, 26(2).
- . eBioMedicine, 87.
- . American Journal of Respiratory and Critical Care Medicine, 207(6), 693-703.
- . High Altitude Medicine and Biology.
- . International Journal of Cardiology.
- . The Lancet Respiratory Medicine.
- . American Journal of Respiratory and Critical Care Medicine.
- . The Lancet Digital Health, 4(7), e477-e477.
- . The Lancet Respiratory Medicine.
- . American Journal of Respiratory and Critical Care Medicine.
- . Radiology, 305(3).
- . Heart, 108, 1392-1400.
- . Open Forum Infectious Diseases, 9(5).
- . The Lancet Respiratory Medicine.
- . ERJ Open Research.
- . ERJ Open Research, 8(2).
- . Frontiers in Cardiovascular Medicine, 9.
- . The Lancet Digital Health, 4(4), e220-e234.
- . Frontiers in Physiology, 13.
- . Cell, 185(3), 467-484.e15.
- . Nephrology Dialysis Transplantation, 37(2), 271-284.
- . Heart.
- . Nature Communications, 12.
- . iScience, 24(11).
- . BMJ Open, 11(10).
- . The Lancet Respiratory Medicine.
- . Infection, 49(5), 889-905.
- . Science.
- . BMJ Open Respiratory Research, 8(1).
- . European Respiratory Review, 30(161), 210053-210053.
- . The Lancet, 398(10296), 223-237.
- . Nature, 600(7889), 472-477.
- . EBioMedicine, 69, 103444-103444.
- . BMC Health Services Research, 21.
- . The Lancet Microbe.
- . The Lancet Rheumatology, 3(6), e393-e393.
- . The Lancet Respiratory Medicine.
- . International Journal of Cardiovascular Imaging.
- . The Lancet Rheumatology.
- . The Lancet Respiratory Medicine.
- . Cell Metabolism, 33(2), 411-423.e4.
- . The Lancet Respiratory Medicine.
- . Arteriosclerosis, thrombosis, and vascular biology, 41(1), 430-445.
- . Nature.
- . JACC: Cardiovascular Imaging.
- . American Journal of Respiratory and Critical Care Medicine, 202(12), 1656-1665.
- . Annals of the American Thoracic Society.
- . American Journal of Respiratory and Critical Care Medicine, 0(ja), 586-594.
- . Frontiers in medicine, 7, 352.
- . European Respiratory Journal.
- . The European respiratory journal, 55(6).
- . International Journal of Molecular Sciences, 21(9).
- . Respirology.
- . American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468.
- . BJU International, 125(5), 669-678.
- . Thrombosis and Haemostasis, 120(02), 253-261.
- . Nature Communications, 10(1).
- . Elife, 8.
- . Frontiers in Medicine, 6.
- . Pulmonary Circulation.
- . American Journal of Respiratory and Critical Care Medicine, 199(2).
- . European Respiratory Journal, 52(3).
- . Frontiers in Medicine, 5.
- . High Altitude Medicine & Biology, 19(1), 4-6.
- . Thrombosis and Haemostasis, 118(01), 063-071.
- . Pulmonary Circulation, 8(1), 1-11.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2087-2101.
- . Journal of Clinical Investigation, 127(9), 3407-3420.
- . Science Immunology, 2(8).
- . Trends in Molecular Medicine, 23(1), 31-45.
- . Microbes and Infection.
- . European Respiratory Journal, 48(5), 1514-1514.
- . Blood, 127(21), 2641-2644.
- . Nature, 522(7556), 349-353.
- . Nature Medicine, 20(8), 809-811.
- . PloS one, 9(1), e81229.
- . Blood, 123(3), 366-376.
- . Biological Chemistry, 394(4), 471-477.
- . HIGH ALTITUDE MEDICINE & BIOLOGY, 13(4), 263-268.
- . Thorax, 67(11), 985-992.
- . Thorax, 67(9), 796-803.
- . Journal of Clinical Investigation, 121(3), 1053-1063.
- . C13. PATHOGENESIS OF ACUTE LUNG INJURY.
- . High Altitude Medicine and Biology, 12(3), 207-214.
- . Journal of Immunology, 186(1), 453-463.
- . High Alt Med Biol, 11(3), 217-222.
- . EUR RESPIR J, 35(1), 221-222.
- . Respir Med, 103(8), 1182-1188.
- . QJM, 102(5), 341-348.
- . HIGH ALT MED BIOL, 9(4), 307-310.
- Manual Assessment of the Initial Fall in Blood Pressure After Orthostatic Challenge at High Altitude. WILD ENVIRON MED, 19(4), 225-232.
- . Chest, 131(5), 1473-1478.
- Phosphodiesterase type 5 inhibitors in the treatment and prevention of high altitude pulmonary edema. CURR OPIN INVESTIG D, 8(3), 226-231.
- . Respir Med, 101(3), 587-594.
- . Eur J Emerg Med, 13(3), 184-186.
- . HEART, 92(4), 539-540.
- Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at altitude. HIGH ALT MED BIOL, 7(3), 221-227.
- . Annals of the American Thoracic Society.
- . ERJ Open Research, 00474-2024.
- . ERJ Open Research, 00059-02024.
- . International Journal of Epidemiology.
- . Scientific Reports, 13(1).
- . Pulmonary Circulation.
- . Frontiers in Medicine, 5.
- . Hypoxia, 47-47.
- . ERJ Open Research, 00046-2021.
- . Frontiers in Medicine, 7.
Conference proceedings papers
- . 鈥楾he Never-Ending Story鈥 (of long COVID) (pp A59.2-A60)
- . Clinical respiratory physiology, exercise and functional imaging (pp PA5261-PA5261)
- . Imaging (pp PA5251-PA5251)
- . Imaging (pp PA5252-PA5252)
- . Pulmonary hypertension (pp PA2492-PA2492)
- . Imaging (pp PA5250-PA5250)
- . D95. SURVEYING THE ZOO: -OMICS FOR MECHANISTIC DISCOVERY IN PULMONARY VASCULAR DISEASE
- . The Royal College of Radiologists Open, Vol. 1 (pp 100096-100096)
- . 鈥楤ad blood鈥 鈥 Biomarkers and mechanisms in long COVID
- . 鈥楽hake it off鈥 鈥 Recovery from COVID-19
- . 鈥楽hake it off鈥 鈥 Recovery from COVID-19
- . Imaging
- . Respiratory infections and bronchiectasis
- . Clinical respiratory physiology, exercise and functional imaging
- . Clinical respiratory physiology, exercise and functional imaging (pp PA1180-PA1180)
- . Pulmonary hypertension (pp PA3490-PA3490)
- . Heart Failure
- . Heart Failure
- . Heart Failure
- . Heart Failure
- . Heart Failure
- . Heart Failure
- . Stable IHD/Prevention/Hypertension/Lipids
- . Basic Science
- . A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION
- . D106. HOT OFF THE PRESSES! LATE BREAKERS IN PULMONARY VASCULAR DISEASE
- . D106. HOT OFF THE PRESSES! LATE BREAKERS IN PULMONARY VASCULAR DISEASE
- . B57. INTERMEDIATES, CORRELATES, AND SURROGATES, OH MY!: NOVEL END POINTS AND ASSESSMENTS IN PVD
- . D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE
- . 10.01 - Respiratory infections and bronchiectasis
- . 13.01 - Pulmonary hypertension
- . 13.01 - Pulmonary hypertension
- . 13.01 - Pulmonary hypertension
- . 鈥業nfinity War鈥 鈥 Ongoing clinical challenges in COVID-19
- . 鈥楥ontagion鈥 鈥 The impact of COVID-19
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楳ission (Im)possible I鈥 鈥 Pulmonary vascular disease
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楳ission (Im)possible I鈥 鈥 Pulmonary vascular disease
- . Circulation, Vol. 146(Suppl_1) (pp a13553-a13553)
- . Circulation, Vol. 146(Suppl_1) (pp a13527-a13527)
- . Circulation, Vol. 146(Suppl_1) (pp a10848-a10848)
- . C30. LIFE AND LUNGS AFTER COVID: FUNCTIONAL RECOVERY AND OUTCOMES FOLLOWING SARS-CoV2 INFECTION (pp a3914-a3914)
- . D17. TOP KNOWLEDGE IN COVID (pp a5050-a5050)
- . D17. TOP KNOWLEDGE IN COVID (pp a5055-a5055)
- . B96. FISHERMAN'S WHARF: OMICS AND TRANSLATIONAL APPROACHES IN PULMONARY VASCULAR DISEASE (pp a3440-a3440)
- . C55. NOB HILL: CELLULAR ORIGINS OF PULMONARY VASCULAR DISEASE (pp a4432-a4432)
- . Pulmonary hypertension
- . Circulation, Vol. 144(Suppl_1)
- . Heart failure
- . The nuts and bolts of ILD clinical management
- Heart Rhythm versus Heart Rate Control Strategy in Patients With Pre-Capillary Pulmonary Hypertension and Atrial Arrhythmias. CIRCULATION, Vol. 144
- . Circulation, Vol. 142(Suppl_3)
- . Pulmonary hypertension
- . Pulmonary hypertension
- . Pulmonary hypertension
- . A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE
- . B27. HEARTBREAKER: HEART FAILURE AND PULMONARY HYPERTENSION
- . A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH
- . A97. STATION TO STATION: UNRAVELING THE MOLECULAR PATHOGENESIS OF PAH
- . BTS/BALR/BLF Early Career Investigators awards symposium
- . Pulmonary hypertension
- . Pulmonary hypertension
- Vascular Smooth Muscle Derived TRAIL is Required for Development of Pulmonary Arterial Hypertension in Sugen 5416 / Hypoxia Mice. CIRCULATION, Vol. 138
- . Pulmonary Circulation and Pulmonary Vascular Disease
- . Pulmonary vascular disease: monitoring and managing
- . Advances in understanding chronic thrombo-embolic disease and pulmonary hypertension
- . Pulmonary vascular disease: monitoring and managing
- . Thorax, Vol. 71(Suppl 3) (pp A61.2-A62)
- . Thorax, Vol. 71(Suppl 3) (pp A50.1-A50)
- . Thorax, Vol. 71(Suppl 3) (pp A98.1-A98)
- Deficiency Of Toll-Like Receptor 3 (tlr3) Exacerbates Pulmonary Hypertension In Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
- Increased Reactive Oxygen Species Generation In Quiescent And Activated Peripheral Blood Neutrophils In Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 191
- . THORAX, Vol. 68 (pp A140-A140)
- Differential Regulation Of Neutrophil (pmn) Survival By The Prolyl Hydroxylase Enzymes Phd2 And Phd3. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 187
- . THORAX, Vol. 67 (pp A1-A1)
- . D33. ASTHMA PATHOGENESIS
- . C31. REGULATION OF LUNG INFLAMMATION
- The natriuretic response on acute ascent to high altitude. THORAX, Vol. 62 (pp A84-A84)
- High altitude exposure causes a reduction in PFA-100 (TM) closure time in humans: evidence of platelet activation or a result of increased haematocrit?. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 133 (pp 49-50)
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
Preprints
- , Cold Spring Harbor Laboratory.
- , Research Square Platform LLC.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , medRxiv.
- , bioRxiv.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.