Professor Robert Storey
BSc, BM, DM, FRCP, FESC
Clinical Medicine, School of Medicine and Population Health
Professor of Clinical Cardiology
+44 114 305 2055
Full contact details
Clinical Medicine, School of Medicine and Population Health
Northern General Hospital
Herries Road
91探花
S5 7AU
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I joined the University of 91探花 in 2002 as a Senior Clinical Lecturer in Cardiology and subsequently became Professor of Cardiology in January 2011. I am Clinical Lead for the Cardiovascular Disease research theme and Director of the Cardiovascular Research Unit. I am also Academic Director for the Cardiology and Cardiothoracic Surgery Directorate and an Honorary Consultant Cardiologist with 91探花 Teaching Hospitals National Health Service Foundation Trust.
I have a special interest in atherothrombosis and antithrombotic therapy in the management of ischaemic heart disease, including coronary intervention. I was Chair of the European Society of Cardiology (ESC) Working Group on Thrombosis 2012-2014 and have been a member of 4 Task Forces for ESC Guidelines as well as author of many ESC position papers. I received a BSc Hons in biochemistry from the University of York, UK, in 1985 before going on to obtain my medical degree (BM) from the University of Southampton in 1989. After completing general professional training, I trained in the fields of Cardiology and General (Internal) Medicine at Queen麓s Medical Centre in Nottingham, completing specialist training in both fields in 2001.
During that time, I developed a keen interest in thrombosis research, studying platelet biology and pharmacology, conducting clinical research studies in patients with cardiovascular disease and obtaining a postgraduate degree in research (DM) from the University of Nottingham.
I have been an Executive/Steering Committee member of numerous international clinical trials such as the PLATO, PEGASUS-TIMI 54, AUGUSTUS and COMPLETE studies and am currently a member of the steering committees for the RAPID-CTCA, SENIOR-RITA, CLEAR-SYNERGY and other studies.
- Research interests
-
My principal research area is atherothrombosis. My particular interests are:
- platelet pharmacology
- relationships between inflammation and atherothrombosis
- fibrin clot properties and thrombotic risk
- cardiovascular clinical trials
- clinical practice guidelines
Current projects
Numerous projects in the areas of antithrombotic therapy and acute coronary syndromes.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . Circulation, 138(13), 1290-1300.
- . European Heart Journal, 39(13), 1078-1085.
- . Journal of the American College of Cardiology, 67(10), 1145-1154.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 35(12), 2562-2570.
- . New England Journal of Medicine, 372(19), 1791-1800.
- . New England Journal of Medicine, 371(11), 1016-1027.
- . Cardiovasc Res, 102(3), 429-435.
- . Eur Heart J, 32(23), 2945-2953.
- . Arterioscler Thromb Vasc Biol, 30(12), 2385-2391.
- . J Am Coll Cardiol, 56(18), 1456-1462.
- . J Am Coll Cardiol, 56(3), 185-193.
- . NEW ENGL J MED, 361(11), 1045-1057.
- . Circulation, 119(1), 116-122.
All publications
Journal articles
- . JACC: Cardiovascular Interventions, 17(22), 2639-2663.
- . New England Journal of Medicine.
- . New England Journal of Medicine.
- . Circulation, 150(Suppl_1).
- . JACC: Cardiovascular Interventions.
- . European Heart Journal, 45(Supplement_1).
- . European Heart Journal, 45(Supplement_1).
- . European Heart Journal, 45(Supplement_1).
- . European Heart Journal, 45(Supplement_1).
- . European Heart Journal, 45(Supplement_1).
- . Expert Review of Cardiovascular Therapy, 22(9), 471-482.
- . Circulation, 150(4), 317-335.
- . American Heart Journal.
- . The American Journal of Medicine.
- . British Journal of Cardiology.
- . International Journal of Cardiology, 131940-131940.
- . The American Journal of Cardiology.
- . Circulation, 149(8), 601-604.
- . G Ital Cardiol (Rome), 25(2 Suppl 2), e1-e112.
- . European Heart Journal: Acute Cardiovascular Care, 13(1), 55-161.
- . British Journal of Cardiology.
- . European Heart Journal, 44(Supplement_2).
- . European Heart Journal, 44(Supplement_2).
- . European Heart Journal, 44(Supplement_2).
- . JACC: Advances, 2(9), 100675-100675.
- . Journal of the American College of Cardiology, 82(17), B250-B251.
- . Circulation: Cardiovascular Interventions, 16(9).
- . American Heart Journal, 266, 138-148.
- . American Heart Journal.
- . European Heart Journal, 44(38), 3720-3826.
- . International Journal of Cardiology, 131291-131291.
- . JAMA Cardiology, 8(8), 755-755.
- . Circulation, 147(25), 1933-1944.
- . Journal of the American College of Cardiology, 81(19), 1933-1936.
- . European Heart Journal - Cardiovascular Pharmacotherapy, 9(5), 462-496.
- . Cardiovascular Research, 119(7), 1596-1605.
- . Vascular Pharmacology, 149, 107145-107145.
- . JTCVS Open.
- . Platelets, 34(1).
- . Diabetes, 71(12), 2483-2485.
- . J Am Coll Cardiol, 80(18), 1735-1747.
- . Cardiovascular Research, 118(Supplement_2).
- . European Heart Journal, 43(Supplement_2).
- . Journal of the American College of Cardiology, 80(12), B15-B15.
- . Journal of the American College of Cardiology, 80(12), B15-B15.
- . European Heart Journal, 43(39), 3826-3924.
- . Journal of Thoracic Disease, 14(8), 3030-3044.
- . Health Technol Assess, 26(37), 1-114.
- . Nat Rev Cardiol.
- . Eur Heart J Cardiovasc Pharmacother.
- . European Heart Journal: Acute Cardiovascular Care.
- . JACC: Cardiovascular Imaging.
- . Catheterization and Cardiovascular Interventions.
- . Journal of the American College of Cardiology, 79(9), 1220.
- . Journal of the American College of Cardiology, 79(9), 1140.
- . Journal of the American College of Cardiology, 79(9), 575.
- . Journal of the American College of Cardiology, 79(9), 1094-1094.
- . Nat Rev Cardiol.
- . Cardiovascular Diabetology, 20(1).
- . Circulation, 144(Suppl_1), a13221-a13221.
- . Circulation, 144(Suppl_1), a12512-a12512.
- . Journal of the American College of Cardiology, 78(19), B82-B83.
- . European Heart Journal, 42(Supplement_1).
- . BMJ: British Medical Journal, 374.
- . Eur Heart J.
- . Eur Heart J.
- . Journal of Cardiovascular Pharmacology, Publish Ahead of Print.
- . Journal of the American Heart Association, 10(17).
- . European Heart Journal, 42(31), 2973-2985.
- . Reviews in Cardiovascular Medicine, 22(2), 373-394.
- . Platelets, 1-7.
- . J Thromb Thrombolysis.
- . Cochrane Database of Systematic Reviews, 2021(5).
- . Journal of the American College of Cardiology, 77(18), 933.
- . European Heart Journal, 42(14), 1289-1367.
- . Heart.
- . JACC: Basic to Translational Science, 6(3), 219-221.
- . Molecular & Cellular Proteomics, 20.
- . Journal of the American Heart Association, 10(4).
- Contra. EUROPEAN HEART JOURNAL, 42(31), 2979-2985.
- . Rev Esp Cardiol (Engl Ed), 74(6), 544.
- . European Heart Journal. Acute Cardiovascular Care, 10(2), 153-163.
- . European Heart Journal Supplements, 22(Supplement_M), M26-M34.
- . Cardiovascular Diabetology, 19(1).
- . Circulation, 142(Suppl_3).
- . European Heart Journal, 41(Supplement_2).
- . Vascular Biology.
- . European Heart Journal, 41(37), 3495-3497.
- . European Heart Journal, 41(37), 3546-3548.
- . Journal of the American College of Cardiology, 76(11), 1277-1286.
- . EuroIntervention.
- . Journal of the American Heart Association, 9(17).
- . International Journal of Cardiology.
- . Diabetes and Vascular Disease Research, 17(5).
- . Journal of the American College of Cardiology, 76(2), 162-171.
- . Heart, 106(Suppl 2), a41-a41.
- . Circulation: Cardiovascular Interventions, 13(7).
- . Revista Espa帽ola de Cardiolog铆a, 73(6), 495.e1-495.e61.
- . Journal of the American Heart Association, 9(10).
- . Journal of the American Heart Association, 9(10).
- . International Journal of Molecular Sciences, 21(8).
- . New England Journal of Medicine, 382(16), 1568-1572.
- . Thrombosis and Haemostasis, 120(04), 538-564.
- . Journal of the American College of Cardiology, 75(11), 15-15.
- . Journal of the American College of Cardiology, 75(11), 2194-2194.
- . Journal of the American College of Cardiology, 75(11), 298-298.
- . Expert Opinion on Emerging Drugs.
- . Clinical Research in Cardiology.
- . Journal of the American College of Cardiology, 75(3), 301-303.
- . Thrombosis and Haemostasis, 120(03), 412-422.
- . Nature Reviews Cardiology, 17(4), 242-257.
- . European Heart Journal, 41(3), 407-477.
- . Clinical Research in Cardiology, 109(7), 930-943.
- . EuroIntervention, 15(13), 1125-1129.
- 2019 ghidul SEC pentru diagnosticul si managementul sindroamelor coronariene cronice: Grupul de lucru pentru diagnosticul si managementul sindroamelor coronariene cronice al societatii europeene de cardiologie (SEC). Revista Romana de Cardiologie, 30(3), 467-548.
- . European Heart Journal, 41(3), 483-484.
- . European Heart Journal - Cardiovascular Pharmacotherapy, 6(4), 222-230.
- . European Heart Journal, 41(17), 1625-1632.
- . Thrombosis and Haemostasis, 120(01), 065-074.
- . Circulation, 141(9), 781-783.
- . Atherosclerosis, 293, 35-41.
- . Journal of the American College of Cardiology, 74(22), 2713-2723.
- . EUROPEAN HEART JOURNAL, 40(Suppl 1), 1355-1355.
- . New England Journal of Medicine, 381(15), 1411-1421.
- . European Heart Journal, 40(Supplement_1).
- . Journal of the American College of Cardiology, 74(13), B400-B400.
- . European Heart Journal - Cardiovascular Pharmacotherapy, 5(4), 200-206.
- . JAMA Cardiology, 4(11), 1092-1092.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 39(11), 2402-2410.
- . Platelets.
- . Thrombosis and Haemostasis, 119(10), 1573-1582.
- . Thrombosis and Haemostasis, 119(10), 1590-1605.
- . Journal of the American College of Cardiology, 74(5), 699-711.
- . American Heart Journal, 215, 157-166.
- . JACC: Cardiovascular Interventions, 12(16), 1521-1537.
- . JACC: Cardiovascular Interventions, 12(10), 993-994.
- . American Heart Journal, 213, 57-65.
- . Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199.
- . Journal of the American Heart Association, 8(6).
- . New England Journal of Medicine.
- . European Heart Journal, 40(24), 1971-1974.
- . Thrombosis and Haemostasis.
- . Cardiovascular Research, 115(10), 1512-1518.
- . Platelets, 30(2), 148-157.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 39(2), 294-302.
- . American Journal of Cardiovascular Drugs, 19(2), 173-183.
- . Catheterization and Cardiovascular Interventions, 93(7), E369-E377.
- . EP Europace, 21(2), 192-193.
- . Platelets, 30(5), 579-588.
- . Diabetes Care, 41(12), 2625-2633.
- . Journal of the American Heart Association, 7(22).
- . JAMA Cardiology, 3(12), 1160-1160.
- . British Journal of Clinical Pharmacology.
- . Circulation, 138(Suppl_1).
- . Circulation, 138(Suppl_1).
- . Circulation, 138(13), 1290-1300.
- . European Heart Journal, 39(suppl_1).
- . European Heart Journal, 39(suppl_1).
- . Nature Reviews Cardiology, 15(8), 480-496.
- . Thrombosis and Haemostasis, 118(07), 1250-1256.
- . Circulation, 137(21), 2310-2311.
- . American Heart Journal, 202, 54-60.
- . European Heart Journal, 39(13), 1078-1085.
- . Blood Advances, 2(6), 715-730.
- . Heart, 104(19), 1555-1556.
- . European Heart Journal, 39(19), 1672-1686f.
- Clot lysis time could identify heart attack patients most at risk of subsequent cardiovascular disease. BRITISH JOURNAL OF HOSPITAL MEDICINE, 79(3), 131-131.
- . Circulation, 137(7), 684-692.
- . Journal of the American College of Cardiology, 71(5), 489-496.
- . Thrombosis and Haemostasis, 118(02), 427-429.
- . American Heart Journal, 196, 56-64.
- . European Heart Journal, 39(3), e1-e33.
- . European Heart Journal, 39(3), 213-260.
- . Journal of the American Heart Association, 7(2).
- . Journal of the American College of Cardiology, 71(1), 108-108.
- . European Journal of Cardio-thoracic Surgery, 53(1), 34-78.
- . Revista Espa帽ola de Cardiolog铆a, 71(1), 42.e1-42.e58.
- . European Heart Journal, 39(3), 209-211.
- . EP Europace, 19(11), 1757-1758.
- . Circulation, 136(20), 1955-1975.
- . Journal of the American College of Cardiology, 70(14), 1760-1776.
- . International Journal of Cardiology, 244, 49-53.
- . Journal of the American College of Cardiology, 70(11), 1368-1375.
- . European Heart Journal: Acute Cardiovascular Care, 6(6), 500-510.
- . JACC - Journal of the American College of Cardiology bts, 2(4), 398-414.
- . European Heart Journal: Acute Cardiovascular Care.
- . European Heart Journal, 38(suppl_1).
- . European Heart Journal, 38(suppl_1).
- . Journal of the American College of Cardiology, 70(5), 527-538.
- . Journal of Thrombosis and Thrombolysis, 44(2), 145-153.
- . Clin Cardiol.
- . European Heart Journal, 38(22), 1710-1716.
- . EuroIntervention, 13(1), 69-77.
- . The American Journal of Cardiology, 119(8), 1135-1140.
- . Journal of the American Heart Association, 6(4), e005580-e005580.
- . American Heart Journal, 186, 91-99.
- . Thrombosis and Haemostasis, 117(5), 940-947.
- . Platelets, 28(8), 767-773.
- . Semin Thromb Hemost, 43(3), 311-319.
- . European Heart Journal, 38(7), 472-472.
- . Clinical Chemistry, 63(2), 573-584.
- . Int. Journal of Clinical Pharmacology and Therapeutics, 55(05), 416-424.
- . Thrombosis and Haemostasis, 117(2), 295-302.
- . Interv Cardiol Clin, 6(1), 49-55.
- . Thrombosis and Haemostasis, 117(06), 1093-1100.
- . Blood, 128(23), 2595-2597.
- . Trials, 17(1), 579-579.
- . The Journal of Clinical Pharmacology.
- . Circulation, 134(suppl_1).
- . European Heart Journal, ehw454-ehw454.
- 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Giornale Italiano di Cardiologia, 17(10), 831-872.
- . Circulation, 134(12), 861-871.
- . Circulation, 134(11), 793-796.
- . Thrombosis and Haemostasis, 116(6), 1079-1088.
- . Int. Journal of Clinical Pharmacology and Therapeutics, 54(09), 666-674.
- . Vascular Pharmacology, 84, 25-27.
- . Expert Review of Cardiovascular Therapy, 14(9), 991-999.
- . JAMA Cardiology, 1(4), 425-425.
- . American Heart Journal, 177, 1-8.
- . Journal of the American College of Cardiology, 67(23), 2719-2728.
- . Journal of the American College of Cardiology, 67(23), 2732-2740.
- . Thrombosis and Haemostasis, 116(2), 369-378.
- . Heart, 102(10), 783-789.
- . Thrombosis and Haemostasis, 116(1), 96-102.
- . Heart, 102(8), 617-625.
- . Current Cardiology Reports, 18(5).
- . JACC: Cardiovascular Interventions, 9(7), 646-656.
- . Thrombosis and Haemostasis, 115(4), 685-711.
- . Human Molecular Genetics, 25(7), 1447-1456.
- . Journal of the American College of Cardiology, 67(10), 1145-1154.
- . Russian Journal of Cardiology, 131(3), 9-63.
- . Circulation Research, 118(3), 420-432.
- . JACC: Cardiovascular Interventions, 9(4), S22-S22.
- . Circulation: Arrhythmia and Electrophysiology, 9(2).
- . European Heart Journal, 37(3), 267-315.
- CardioPulse: 'Ten Commandments' of 2015 European Society of Cardiology Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (NSTE-ACS).. Eur Heart J, 37(3), 208.
- . International Journal of Cardiology, 202, 167-173.
- . European Heart Journal, 37(14), 1133-1142.
- . European Heart Journal, 37(16), 1325-1333.
- . European Heart Journal: Acute Cardiovascular Care, 5(1), 3-12.
- . Revista Espa帽ola de Cardiolog铆a (English Edition), 68(12), 1125-1125.
- . Revista Espa帽ola de Cardiolog铆a, 68(12), 1125.e1-1125.e64.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 35(12), 2562-2570.
- . Circulation, 132(suppl_3).
- . Circulation, 132(suppl_3).
- . Circulation, 132(suppl_3).
- . Circulation, 132(suppl_3).
- . EuroIntervention, 11(8), 793-798.
- . EuroIntervention, 11(8), 737-745.
- . Journal of the American Heart Association, 4(10).
- . Thrombosis and Haemostasis, 114(09), 449-458.
- . Platelets, 27(3), 191-195.
- . Vascular Pharmacology, 71, 201-207.
- . Thrombosis and Haemostasis, 114(09), 490-497.
- . Platelets, 26(5), 392-398.
- . New England Journal of Medicine, 372(19), 1791-1800.
- . European Heart Journal, 36(27), 1714-1717.
- . European Heart Journal, 36(29), 1901-1912.
- . Platelets, 26(3), 271-273.
- . The American Journal of Medicine, 128(8), 914.e11-914.e19.
- . American Heart Journal, 170(3), 465-470.
- . Circulation: Cardiovascular Genetics, 8(3), 498-506.
- . American Heart Journal, 169(6), 879-889.e7.
- . Journal of the American College of Cardiology, 65(5), 516-518.
- . Thrombosis and Haemostasis, 113(02), 221-230.
- . Thrombosis and Haemostasis, 113(01), 37-52.
- . Kardiologia Polska, 1207-1294.
- . Thrombosis and Haemostasis, 113(01), 37-52.
- . European Heart Journal, 36(2), 83-93.
- . European Heart Journal: Acute Cardiovascular Care, 4(6), 555-560.
- . Heart, 101(2), 119-125.
- . European Heart Journal: Acute Cardiovascular Care, 4(3), 254-262.
- . Platelets, 26(3), 236-242.
- . European Journal of Preventive Cardiology, 22(6), 734-742.
- . New England Journal of Medicine, 371(24), 2337-2339.
- . N Engl J Med, 371(24), 2338-2339.
- . European Heart Journal, 35(45), 3155-3179.
- . Circulation, 130(suppl_2).
- . Circulation, 130(suppl_2).
- . Journal of the American College of Cardiology, 64(12), 1270-1280.
- . New England Journal of Medicine, 371(11), 1016-1027.
- . European Heart Journal, 35(31), 2083-2093.
- . Postgraduate Medical Journal, 90(1067), 520-528.
- . Int J Cardiol, 176(1), 300-302.
- . Heart, 100(22), 1762-1769.
- . European Heart Journal, 35(23), 1510-1514.
- . Eur Heart J, 35(23), 1541-1550.
- . Heart, 100(Suppl 3), A117.3-A118.
- . Clin Med (Lond), 14(3), 323-324.
- . CIRCULATION, 129(19), E494-E495.
- . Thrombosis and Haemostasis, 112(1), 12-14.
- . THROMBOSIS AND HAEMOSTASIS, 111(5), 781-782.
- . American Heart Journal, 168(4), 530-536.
- . J Am Coll Cardiol, 63(11), 1048-1057.
- . J Am Coll Cardiol, 63(15), 1493-1499.
- . Cardiovasc Res, 102(3), 429-435.
- . Circulation, 129(3), 293-303.
- . Thrombosis and Haemostasis, 112(12), 1077-1078.
- . American Heart Journal.
- . Thrombosis and Haemostasis, 111(5), 883-891.
- . Prog Mol Biol Transl Sci, 124, 123-153.
- . European Heart Journal, 35(4).
- . American Heart Journal.
- . Am J Cardiol, 113(6), 936-944.
- . J Cardiovasc Transl Res, 7(1), 19-28.
- . Platelets, 25(7), 517-525.
- . Platelets, 25(6), 416-422.
- . Circulation, 128(suppl_22).
- Vorapaxar in Acute Coronary Syndrome Patients Undergoing Coronary Artery Bypass Graft Surgery: Subgroup Analysis from the TRACER Trial.. J Am Coll Cardiol..
- . JACC: Cardiovascular Interventions, 6(11), 1111-1128.
- Biomarkers in Relation to the Effects of Ticagrelor Compared with Clopidogrel in Non-ST-Elevation Acute Coronary Syndrome Patients Managed with or without In-Hospital Revascularization: A Substudy from the Prospective Randomized Platelet Inhibition and Patient Outcomes (PLATO) Trial.. Circulation.
- . Circulation, 128(10), 1055-1065.
- . Clinical Chemistry, 59(9), 1369-1375.
- . European Heart Journal, 34(suppl 1), P4881-P4881.
- . European Heart Journal, 34(suppl 1), P4048-P4048.
- . European Heart Journal, 34(suppl 1), P4901-P4901.
- . European Heart Journal, 34(suppl 1), 4536-4536.
- . European Heart Journal, 34(suppl 1), 4533-4533.
- PAR-1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 444-444.
- Diabetes modulates the fibrinolytic properties of aspirin without altering the platelet inhibitory actions: a possible mechanism for aspirin treatment failure. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 760-760.
- Zebrafish as a model to investigate the effect of P2Y12 knockdown on leukocyte migration. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 450-450.
- The role of vessel wall P2Y12 in early atherogenesis is not blocked by ticagrelor or clopidogrel. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 156-156.
- Evolving pattern of platelet P2Y12 inhibition during maintenance therapy in acute coronary syndrome patients. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 494-494.
- . JACC: Cardiovascular Interventions, 6(7), 671-683.
- . EUROPEAN HEART JOURNAL, 34(23), 1708-+.
- . EuroIntervention, 9(1), 62-69.
- . Stroke, 44(5), 1477-1479.
- . Nature Reviews Cardiology, 10(6), 302-304.
- . Thromb Haemost, 109(5).
- . Circulation, 127(6), 673-680.
- . Thromb Haemost, 109(3), 550-555.
- . Revista Portuguesa de Cardiologia (English Edition), 32(1), 83-84.
- . Revista Portuguesa de Cardiologia (English Edition), 32(1), 81-82.
- Outcomes with ticagrelor versus clopidogrel in relation to high sensitivity troponin-T in non-ST-elevation acute coronary syndrome patients managed with early invasive or non-invasive treatment: a substudy from the prospective randomized PLATelet inhibit.. Pharmacotherapy(33), E189-E189.
- . International Journal of Cardiology.
- . PLATELETS, 24(8), 643-648.
- . Thrombosis and Haemostasis, 110(3), 609-615.
- . American Journal of Medicine, 126(8).
- . Value in Health, 16(4), 574-580.
- An International Perspective of Current Patterns of Antiplatelet Drug Use in Acute Coronary Syndrome Patients. Results from the EPICOR Study. CIRCULATION, 126(21).
- . Nature Reviews Cardiology, 9(11), 620-633.
- Platelet Function Testing in Atherothrombotic Disease. CURRENT PHARMACEUTICAL DESIGN, 18(33), 5379-5391.
- . European Heart Journal, 33(21), 2750-2750.
- . Journal of the American College of Cardiology, 60(16), 1581-1598.
- . Circulation, 126(16), 2020-2035.
- . European Heart Journal, 33(20), 2551-2567.
- . CIRCULATION, 126(11), E171-E172.
- . CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 5(5), 680-688.
- . Curr Pharm Des, 18(33), 5240-5260.
- . Giornale Italiano di Cardiologia, 13(3), 171-228.
- . Revista Espa帽ola de Cardiolog铆a (English Edition), 65(2), 173-173.
- . Revista Espa帽ola de Cardiolog铆a, 65(2), 173.e1-173.e55.
- . Hosp Pract (1995), 40(1), 224-231.
- . American Heart Journal.
- . Journal of the American College of Cardiology.
- . Circulation, 125(23), 2914-2921.
- . CMAJ, 184(10), 1135-1142.
- Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. American Heart Journal.
- . Clinical Pharmacokinetics, 51(6), 397-409.
- . Circulation, 125(8), 978-986.
- . New England Journal of Medicine, 366(1), 20-33.
- . Circulation, 125(3), 514-521.
- . Postgrad Med J, 88(1035), 49-54.
- . CLINICAL CHEMISTRY, 58(1), 190-199.
- . Curr Treat Options Cardiovasc Med, 14(1), 24-38.
- Wytyczne dotycza抬ce diagnostyki i leczenia ostrych zespo艂贸w wie艅cowych bez przetrwa艂ego uniesienia odcinka ST. Kardiologia Polska, 69(SUPPL. 5).
- . Circulation, 1-1.
- Wytyczne ESC/EAS dotycza抬ce post锚powania w dyslipidemiach. Kardiologia Polska, 69(SUPPL. 4).
- . Revista Espa帽ola de Cardiolog铆a (English Edition), 64(12), 1168-1168.
- . European Heart Journal, 32(23), 2999-3054.
- Israrci ST-segment y眉kselmesi belirtileri g枚stermeyen hastalarda Akut KoronerSendromlarin (AKS) tedavi kilavuzlari. Turk Kardiyoloji Dernegi Arsivi, 39(SUPP -3), 73-128.
- ESC/EAS Kilavuzlari: Dislipidemilerin tedavisi. Turk Kardiyoloji Dernegi Arsivi, 39(SUPP -3), 5-72.
- . Revista Espa帽ola de Cardiolog铆a, 64(12), 1168.e1-1168.e60.
- Cardiovascular Events in Acute Coronary Syndrome Patients With Peripheral Arterial Disease Treated With Ticagrelor Compared to Clopidogrel: Data From the PLATO Trial. CIRCULATION, 124(21).
- Ticagrelor Versus Clopidogrel in Patients with Acute Coronary Syndromes and History of Stroke or Transient Ischemic Accident: Results from the Platelet Inhibition and Patient Outcomes Trial. CIRCULATION, 124(21).
- . Am J Cardiol, 108(11), 1542-1546.
- Ticagrelor Compared with Clopidogrel by Geographic Region in the Platelet Inhibition and Patient Outcomes (PLATO) Trial. CIRCULATION, 124(5), 660-660.
- . CIRCULATION, 124(5), 544-U78.
- Serial renal function assessment with cystatin c in patients with acute coronary syndrome randomized to ticagrelor or clopidogrel. EUROPEAN HEART JOURNAL, 32, 417-417.
- Stent thrombosis with ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention -an analysis from the prospective randomized PLATO trial. EUROPEAN HEART JOURNAL, 32, 415-416.
- . HEART, 97(15), 1262-1267.
- . Eur Heart J, 32(23), 2945-2953.
- . Atherosclerosis, 217, 1-44.
- . Atherosclerosis, 217(1), 3-46.
- . European Heart Journal, 32(14), 1769-1818.
- . J Thromb Haemost, 9(9), 1730-1737.
- . BRIT MED J, 342.
- . THROMB HAEMOSTASIS, 105, S34-S42.
- . J AM COLL CARDIOL, 57(19), 1908-1916.
- . Thromb Haemost, 105 Suppl 1, S1-S2.
- . Thromb Haemost, 105 Suppl 1, S75-S81.
- . J Am Coll Cardiol, 57(9), 1078-1080.
- . Biomark Med, 5(1), 53-62.
- Optimal Management of Antiplatelet Therapy and Proton Pump Inhibition Following Percutaneous Coronary Intervention. Current Treatment Options in Cardiovascular Medicine, 1-15.
- . European Heart Journal, 32(23), 2933-2944.
- . European Heart Journal, 32(23), 2922-2932.
- . American Journal of Cardiology, 108(11), 1542-1546.
- The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: Combined analysis of the ONSET/OFFSET and RESPOND studies. American Heart Journal.
- . J Am Coll Cardiol, 57(6), 672-684.
- Sustained P2Y12 Receptor Inhibition is Required to Effectively Inhibit Neointima Formation in a Murine Vascular Injury Model. CIRCULATION, 122(21).
- First Analysis of Relation Between CYP2C19 Genotype and Platelet Function in Ticagrelor versus Clopidogrel Treated Patients: Results from the ONSET/OFFSET and RESPOND Studies. CIRCULATION, 122(21).
- . J AM COLL CARDIOL, 56(22), 1895-1895.
- . Circ Cardiovasc Genet, 3(6), 556-566.
- . Arterioscler Thromb Vasc Biol, 30(12), 2385-2391.
- . Circulation, 122(21), 2131-2141.
- . J Neurol Neurosurg Psychiatry, 81(11), e69-e70.
- . Diab Vasc Dis Res, 7(4), 249-250.
- . CIRCULATION, 122(11), 1056-1067.
- . J Am Coll Cardiol, 56(18), 1456-1462.
- . Eur Heart J, 31(24), 3006-3016.
- . PHARMACOL THERAPEUT, 127(2), 95-107.
- . J Am Coll Cardiol, 56(3), 185-193.
- . J Thromb Haemost, 8(8), 1820-1827.
- . Thromb Haemost, 103(6), 1210-1217.
- . PLOS ONE, 5(4).
- . CLIN CARDIOL, 33(4), 206-212.
- . CIRCULATION, 121(10), 1188-1199.
- . Journal of the American College of Cardiology, 55(10), A108.E1007-A108.E1007.
- . Journal of the American College of Cardiology, 55(10), A108.E1006-A108.E1006.
- . LANCET, 375(9711), 283-293.
- . Pharmacology and Therapeutics, 128(2), 385.
- . Therapeutic Advances in Cardiovascular Disease, 4(4), 249-275.
- Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. The Lancet.
- . Circulation, 120(25), 2577-2585.
- The right oral antithrombotics in acute coronary syndromes. LANCET, 374(9706), 1947-1948.
- . EUR HEART J SUPPL, 11(G), G25-G26.
- . EUR HEART J SUPPL, 11(G), G2-G3.
- . Circulation, 120(suppl_18).
- . Circulation, 120(suppl_18).
- . Circulation, 120(suppl_18).
- . Circulation, 120(suppl_18).
- . Circulation, 120(suppl_18).
- . NEW ENGL J MED, 361(11), 1045-1057.
- Cangrelor inhibits the binding of clopidogrel and prasugrel active metabolites to the P2Y12 receptor. EUROPEAN HEART JOURNAL, 30, 193-193.
- . AM HEART J, 158(3), 327-U5.
- . Platelets, 20(5), 341-348.
- . AM HEART J, 157(4), 599-605.
- . INT J CLIN PRACT, 63(4), 667-670.
- , 1-14.
- . Lancet, 373(9660), 276-278.
- . Circulation, 119(1), 116-122.
- Final aggregation response is a more sensitive marker of the effects of P2Y12 receptor antagonists than maximal aggregation response. EUROPEAN HEART JOURNAL, 29, 405-405.
- Platelet function assays that assess response to P2Y12 antagonists vary widely in their sensitivities to low levels of P2Y12 receptor blockade. EUROPEAN HEART JOURNAL, 29, 835-835.
- . DIABETOLOGIA, 51(3), 385-390.
- . Platelets, 19(2), 125-133.
- . PLATELETS, 19(4), 239-251.
- , 1-2.
- , 1-4.
- , 1-3.
- . J AM COLL CARDIOL, 50(22), 2196-2196.
- . J AM COLL CARDIOL, 50(19), 1844-1851.
- . J Am Coll Cardiol, 50(19), 1852-1856.
- Abciximab can potentiate platelet alpha-granule release and this effect is prevented by the P2Y12 antagonist cangrelor. EUROPEAN HEART JOURNAL, 28, 665-666.
- . Journal of Thrombosis and Haemostasis, 5.
- . Thromb Haemost, 95(6), 997-1002.
- . Platelets, 17(4), 250-258.
- . Curr Pharm Des, 12(10), 1255-1259.
- . Platelets, 16(7), 398-407.
- Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor.. Thromb Haemost, 94(4), 831-838.
- . Platelets, 16(6), 340-345.
- . The Annals of Thoracic Surgery, 80(1), 149-152.
- . PLATELETS, 16(2), 73-80.
- . Thromb Res, 115(4), 301-307.
- . Platelets, 15(8), 465-474.
- . Catheter Cardiovasc Interv, 63(3), 397-398.
- . British Journal of Clinical Pharmacology, 58(4), 442-442.
- . POSTGRAD MED J, 80(941), 155-164.
- . Platelets, 13(7), 407-413.
- Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin.. Thromb Haemost, 88(3), 488-494.
- . Platelets, 12(7), 443-447.
- . Platelets, 12(4), 197-209.
- Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes.. Thromb Haemost, 85(3), 401-407.
- . Br J Haematol, 110(4), 925-934.
- P2T receptor activation by released ADP dramatically amplifies platelet procoagulant activity and calcium mobilisation induced by thrombin receptor (PAR1) activation. EUR HEART J, 21, 66-66.
- In vitro evidence supporting direct platelet P2T receptor antagonism as an alternative strategy to glycoprotein IIB/IIIA receptor antagonism. Heart, 83(SUPPL. 1).
- . Blood Coagulation & Fibrinolysis, 10(8), 531-531.
- Heparins sensitize platelets to responses mediated via both the P-2T and the P2Y(1) receptor pathways. CIRCULATION, 100(18), 680-680.
- First clinical study of the novel platelet ADP receptor (P-2 gamma) antagonist AR-C69931MX, assessing safety, tolerability and activity in patients with acute coronary syndromes. CIRCULATION, 100(18), 710-710.
- A whole blood assay of inhibition of platelet aggregation by glycoprotein IIb/IIIa antagonists: comparison with other aggregation methodologies.. Thromb Haemost, 82(4), 1307-1311.
- . Clin Lab Haematol, 21(5), 317-329.
- Influence of the ADP antagonists AR-C67085 and A2P5P on ADP-induced responses of platelets and isolated arteries. BRIT J PHARMACOL, 128, U31-U31.
- Does occupation of the P-2t, receptor on platelets by ADP lead to a reduced rate of Ca2+ re-uptake following Ca2+liberation via the P2Y(1) receptor, and is this mediated by a fall in basal camp?. THROMB HAEMOSTASIS, 355-356.
- Contribution of P-2t, and P2Y(1), receptors to ADP-induced platelet microaggregation in human whole blood. THROMB HAEMOSTASIS, 260-260.
- The effects of a P-2T antagonist on platelet aggregation, platelet activation and platelet-leukocyte conjugate formation in vitro and following administration to patients with unstable angina. THROMB HAEMOSTASIS, 11-11.
- Influence of the ADP antagonists AR-C67085 and A2P5P on ADP-induced responses of platelets and isolated arteries. THROMB HAEMOSTASIS, 166-167.
- Administration of a GPIIb/IIIa antagonist to patients with unstable angina: Effects on platelet aggregation and platelet-leucocyte conjugate formation. THROMB HAEMOSTASIS, 357-358.
- The central role of the P-2T receptor in amplification of platelet aggregation and secretion. THROMB HAEMOSTASIS, 420-420.
- . Hamostaseologie, 19(3), 115-118.
- In vitro effects of the novel platelet adenosine diphosphate receptor (P-2T) antagonist AR-C69931MX and aspirin on platelet aggregation in human whole blood: a potential new therapy for arterial thrombosis.. CIRCULATION, 98(17), 560-560.
- . Circulation, 98(16), 1616-1621.
- Electrocardiogram interpretation - Response. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, 32(1), 85-85.
- Electrocardiogram interpretation as a basis for thrombolysis.. J R Coll Physicians Lond, 31(5), 536-540.
- . European Heart Journal.
- . New England Journal of Medicine.
- . Expert Review of Cardiovascular Therapy, 1-7.
- . Emergency Medicine Journal.
- . Heart.
- . Interventional Cardiology: Reviews, Research, Resources, 19.
- . Journal of Thrombosis and Thrombolysis.
- . Clinical Chemistry and Laboratory Medicine (CCLM), 0(0).
- . Cochrane Database of Systematic Reviews, 2024(1).
- . European Heart Journal: Acute Cardiovascular Care.
- . European Heart Journal - Cardiovascular Pharmacotherapy.
- . NEJM Evidence.
- . Expert Opinion on Drug Metabolism & Toxicology, 1-12.
- . British Journal of Pharmacology.
- . European Heart Journal - Cardiovascular Pharmacotherapy.
- . Journal of Clinical Medicine, 12(17), 5450-5450.
- . Nature Reviews Cardiology.
- . European Heart Journal.
- . European Heart Journal.
- . European Heart Journal - Cardiovascular Pharmacotherapy.
- . Journal of the American Heart Association.
- . Diabetes Care.
- . European Heart Journal.
- . European Heart Journal.
- . JAMA Cardiology.
- . Thrombosis and Haemostasis.
- . Thrombosis and Haemostasis.
- . European Heart Journal. Acute Cardiovascular Care.
- . BMJ, o438-o438.
- . Cardiovascular Research.
- . Clinical Cardiology.
- . Circulation: Cardiovascular Interventions.
- . European Heart Journal.
- . Circulation.
- . Circulation: Genomic and Precision Medicine.
- . Platelets, 1-6.
- . ESC Heart Failure.
- . Circulation.
- . European Heart Journal. Acute Cardiovascular Care.
- . Heart.
- . European Heart Journal - Cardiovascular Pharmacotherapy.
- . JAMA Cardiology.
- . Cardiovascular Drugs and Therapy.
- . JAMA Cardiology.
- . Haematologica, haematol.2019.239558-haematol.2019.239558.
- . European Heart Journal - Cardiovascular Pharmacotherapy.
- . Platelets, 1-8.
- . Platelets, 1-7.
- . European Heart Journal: Acute Cardiovascular Care, 204887261984633-204887261984633.
- . Kardiologia Polska, 76(10), 1383-1415.
- . European Heart Journal, ehv610-ehv610.
- . European Heart Journal, ehv482-ehv482.
- . European Heart Journal, ehv304-ehv304.
- . Global Heart, 7(4), 275-275.
- . Platelets.
- . Journal of Clinical Medicine, 9(7), 2059-2059.
- . European Heart Journal.
- . Clinical Cardiology.
- . Journal of Thrombosis and Thrombolysis, 48(4), 563-569.
Chapters
- In De Caterina R, Moliterno DJ & Kristensen SD (Ed.), The ESC Textbook of Thrombosis (pp. 179-C16P154). Oxford University PressOxford
- , Dual Antiplatelet Therapy for Coronary and Peripheral Arterial Disease (pp. 193-199). Elsevier
- Acute coronary syndromes: Thrombotic Response
- , Platelets in Thrombotic and Non-Thrombotic Disorders (pp. 1015-1028). Springer International Publishing
- In Editors-in-Chief:聽聽S.J. Enna & David B. Bylund (Ed.), xPharm: The Comprehensive Pharmacology Reference (pp. 1-4). New York: Elsevier.
- In Editors-in-Chief:聽聽S.J. Enna & David B. Bylund (Ed.), xPharm: The Comprehensive Pharmacology Reference (pp. 1-2). New York: Elsevier.
Conference proceedings papers
- . Clinical problems (pp PA3889-PA3889)
- . 鈥楾otal eclipse of the heart鈥 鈥 COPD and cardiovascular disease
- . Acute coronary syndromes & Interventional Cardiology
- First Report of the International Safe and Timely Antithrombotic Removal (STAR) Registry. SWISS MEDICAL WEEKLY, Vol. 153 (pp 109S-109S)
- Effects of Complete Revascularization in Relation to Left Ventricular Function in Patients With STEMI and Multivessel Disease: Data from the COMPLETE Randomized trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 82(17) (pp B250-B251)
- DAPA-MI - A Registry-Based Randomized Trial of Dapagliflozin in Patients With Acute Myocardial Infarction Without Diabetes. CIRCULATION, Vol. 148(25) (pp E283-E284)
- Left Anterior Descending Non-culprit Lesion Location And Clinical Outcomes In Patients With St-segment Elevation Myocardial Infarction And Multivessel Disease: Results From The Complete Trial. CIRCULATION, Vol. 148(25) (pp E298-E298)
- . Stable IHD/Prevention/Hypertension/Lipids
- Effects of Complete Revascularization According to Age in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel: Insights From the COMPLETE Trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 80(12) (pp B15-B15)
- Complete Revascularization Versus Culprit Lesion-Only PCI in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease: A Subgroup Analysis of the COMPLETE Trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 80(12) (pp B15-B15)
- Treatment and prognosis of elderly patients with non-ST-elevation myocardial infarction. EUROPEAN HEART JOURNAL, Vol. 43 (pp 2541-2541)
- Temporal changes of biomarkers in myocardial infarction patients with non-obstructive compared to obstructive coronary arteries. EUROPEAN HEART JOURNAL, Vol. 42 (pp 1491-1491)
- Impact of Proton Pump Inhibitors on Efficacy of Antiplatelet Strategies With Ticagrelor or Aspirin After Percutaneous Coronary Intervention. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 78(19) (pp B82-B83)
- The Biomarker-Based ABC-ACS (Age, Biomarkers, Clinical History) Score Can Predict Major Bleeding Better Than Other Contemporary Scores in Patients on Dual Antiplatelet Therapy After Coronary Revascularization: Results of a Large Derivation and Validation Study. CIRCULATION, Vol. 144
- Antithrombotic Strategies According to Age in Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the Augustus Trial. CIRCULATION, Vol. 144
- Rationale, design and feasibility of conducting a real-world study of outcomes in patients with a history of MI receiving extended DAPT with ticagrelor 60 mg. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol. 29 (pp 129-129)
- Rapid Assessment of Potential Ischaemic Heart Disease With Ctca: The Rapid-ctca Trial. A Randomised Trial of Ctcain the Evaluation, Intervention and Outcome Ofadults With Suspected or Confirmed Acute Coronary Syndrome Presenting to the Emergency Department. CIRCULATION, Vol. 142(24) (pp E471-E472)
- . CIRCULATION, Vol. 142
- . Journal of the American College of Cardiology, Vol. 73(9) (pp 196-196)
- Non-Culprit Lesion Plaque Morphology in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Trial Optical Coherence Tomography (OCT) Substudy. CIRCULATION, Vol. 140(25) (pp E982-E983)
- Prolonged Enoxaparin Infusion in Patients Undergoing Primary Percutaneous Coronary Intervention Compared to Standard-of-care: A Single-centre Clinical Trial. CIRCULATION, Vol. 140
- Novel CYP2C19 Genetic Variants Associated With Stent Thrombosis - A Next Generation Sequencing Study. CIRCULATION, Vol. 140
- Dyspnea in ticagrelor treated patients in the all-comer randomized GLOBAL LEADERS study and its association with clinical outcomes. EUROPEAN HEART JOURNAL, Vol. 40 (pp 4011-4011)
- Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
- Impaired fibrin clot lysis persists at 1 month post ACS: a PLATO substudy. EUROPEAN HEART JOURNAL, Vol. 39 (pp 882-883)
- Multiple biomarkers and cause-specific mortality in patients with acute coronary syndromes - Insights from the PLATO biomarker substudy. EUROPEAN HEART JOURNAL, Vol. 39 (pp 145-146)
- . CIRCULATION, Vol. 136
- . Journal of the American College of Cardiology, Vol. 71(11) (pp A1398-A1398)
- . Journal of the American College of Cardiology, Vol. 71(11) (pp A30-A30)
- Patient Selection for Therapies to Prevent Major Adverse Limb Events. CIRCULATION, Vol. 138
- Long-Term Secondary Prevention With Ticagrelor for Prior Myocardial Infarction in Patients With No Coronary Stenting: A Sub-Analysis From PEGASUS TIMI 54. CIRCULATION, Vol. 138
- High-Sensitivity Cardiac Troponin at Any Detectable Concentration Identifies Higher Risk of Major Cardiovascular Events in Patients With Stable Ischemic Heart Disease. CIRCULATION, Vol. 138
- Caffeine and Dyspnea With Ticagrelor: A Sub-Analysis From PEGASUS TIMI-54 Trial. CIRCULATION, Vol. 138
- Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
- Growth differentiation factor 15 and bleeding risk with ticagrelor in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. EUROPEAN HEART JOURNAL, Vol. 38 (pp 612-612)
- Effect of Hypoglycemia on Platelet Reactivity and Platelet-Leukocyte Kinetics. DIABETES, Vol. 66 (pp A41-A41)
- . Heart, Vol. 103(Suppl 5) (pp A53.2-A54)
- . Journal of the American College of Cardiology, Vol. 69(11) (pp 1014-1014)
- Osteoprotegerin is Associated With Major Bleeding but Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes - Insights From the PLATelet Inhibition and Patient Outcomes (PLATO) Trial. CIRCULATION, Vol. 134
- Osteoprotegerin is Associated With Major Bleeding but Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes - Insights From the PLATelet Inhibition and Patient Outcomes (PLATO) Trial. CIRCULATION, Vol. 134
- Impact of presentation and transfer delays on complete ST-segment resolution before primary percutaneous coronary intervention: the ATLANTIC ST-segment resolution substudy. EUROPEAN HEART JOURNAL, Vol. 37 (pp 1173-1173)
- Successful reperfusion is associated with lower levels of markers of myocardial damage and dysfunction in ST-elevation but not in non-ST-elevation myocardial infarction: insights from the PLATO trial. EUROPEAN HEART JOURNAL, Vol. 37 (pp 1282-1283)
- Impact of diabetes mellitus and chronic kidney disease on cardiovascular outcomes and platelet P2Y12 receptor antagonist effects in patients with acute coronary syndromes: insights from the PLATO trial. EUROPEAN HEART JOURNAL, Vol. 37 (pp 1224-1224)
- Platelet P2Y12 inhibitors enhance expansion of the intermediate monocyte population following systemic inflammation in humans. EUROPEAN HEART JOURNAL, Vol. 37 (pp 904-904)
- Potential role of ticagrelor in preventing venous and cardiac thrombosis: insights from PEGASUS-TIMI 54. EUROPEAN HEART JOURNAL, Vol. 37 (pp 636-637)
- . Heart, Vol. 102(Suppl 6) (pp A18-A18)
- . Journal of the American College of Cardiology, Vol. 67(13) (pp 556-556)
- . Journal of the American College of Cardiology, Vol. 67(13) (pp 493-493)
- . Journal of the American College of Cardiology, Vol. 67(13) (pp 2266-2266)
- . Journal of the American College of Cardiology, Vol. 67(13) (pp 2146-2146)
- . Journal of the American College of Cardiology, Vol. 67(13) (pp 2111-2111)
- Long-Term Tolerability of Ticagrelor in the PEGASUS-TIMI 54 Trial. CIRCULATION, Vol. 132(23) (pp 2272-2272)
- Reduction in Total Cardiovascular Events With Long-term Use of Ticagrelor in Patients With Prior Myocardial Infarction in the PEGASUS-TIMI 54 Trial. CIRCULATION, Vol. 132
- Consistent Benefit of Ticagrelor Both Early and Late in Patients With Prior MI in PEGASUS-TIMI 54. CIRCULATION, Vol. 132
- GDF-15 at One Month After an Acute Coronary Syndrome is Associated With Increased Risk of Major Bleeding - A PLATO Biomarker Substudy. CIRCULATION, Vol. 132
- Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. CIRCULATION, Vol. 132
- . Journal of the American College of Cardiology, Vol. 66(15) (pp B36-B36)
- Efficacy and Safety of Ticagrelor for Long-Term Secondary Prevention of Atherothrombotic Events in Relation to Renal Function: Insights from the PEGASUS-TIMI 54 trial. EUROPEAN HEART JOURNAL, Vol. 36 (pp 520-520)
- Pre-hospital ticagrelor in ST-segment elevation myocardial infarction: the French subgroup analysis of the ATLANTIC study. EUROPEAN HEART JOURNAL, Vol. 36 (pp 68-68)
- Balancing the risk of ischaemic and bleeding events in ACS. EUROPEAN HEART JOURNAL, Vol. 36 (pp 860-861)
- The efficacy and safety of ticagrelor in women versus men with a prior myocardial infarction: insights from the PEGASUS-TIMI 54 trial. EUROPEAN HEART JOURNAL, Vol. 36 (pp 549-549)
- Associations of plasma microRNAs with platelet proteins and platelet function. EUROPEAN HEART JOURNAL, Vol. 36 (pp 230-230)
- Ticagrelor 60 mg twice-daily provides effective platelet inhibition in patients with prior myocardial infarction: the PEGASUS-TIMI 54 platelet function substudy. EUROPEAN HEART JOURNAL, Vol. 36 (pp 549-549)
- . Heart, Vol. 101(Suppl 4) (pp A112.1-A112)
- . Journal of the American College of Cardiology, Vol. 65(10) (pp A15-A15)
- . Journal of the American College of Cardiology, Vol. 65(10) (pp A231-A231)
- . Journal of the American College of Cardiology, Vol. 65(10) (pp A221-A221)
- . Journal of the American College of Cardiology, Vol. 65(10) (pp A114-A114)
- . Journal of the American College of Cardiology, Vol. 65(10) (pp A12-A12)
- . Journal of the American College of Cardiology, Vol. 65(10) (pp A259-A259)
- . Atherosclerosis, Vol. 237(2) (pp e5-e5)
- Lower Mortality and Stent Thrombosis Rates Associated With Introduction of Potent P2Y12 Inhibitors in Patients With Acute Coronary Syndromes. CIRCULATION, Vol. 130
- Plasma MicroRNAs Correlate With Platelet Reactivity in Patients With Acute Coronary Syndrome: Association With Platelet Function. CIRCULATION, Vol. 130
- Secreted wingless (Wnt) antagonists and risk prediction in acute coronary syndrome (ACS) a PLATO biomarker substudy. EUROPEAN HEART JOURNAL, Vol. 35 (pp 318-318)
- ApoA1 is independently associated with recurrent ischemic events and death in acute coronary syndrome patients. EUROPEAN HEART JOURNAL, Vol. 35 (pp 482-482)
- Chemokine (CXC motif) ligand 16 (CXCL16) and osteoprotegerin (OPG) as predictors of outcome in patients with acute coronary syndromes (ACS) a PLATO biomarker substudy. EUROPEAN HEART JOURNAL, Vol. 35 (pp 486-486)
- Ticagrelor inhibits release of pro-inflammatory cytokines TNF and IL-6 during human endotoxaemia. European Heart Journal, Vol. 35(Supp1) (pp 1170-1170), 30 August 2014 - 3 September 2014.
- Ticagrelor and dipyridamole potentiate adenosine-induced stimulation of neutrophil chemotaxis in the presence of erythrocytes. EUROPEAN HEART JOURNAL, Vol. 35 (pp 1031-1032)
- . Journal of the American College of Cardiology, Vol. 63(12) (pp A25-A25)
- . Journal of the American College of Cardiology, Vol. 63(12) (pp A18-A18)
- . Journal of the American College of Cardiology, Vol. 63(12) (pp A298-A298)
- CYP2C19 Polymorphism and PON-1 Activity in NSTE ACS: Vorapaxar Effect in Relation to Clopidogrel Metabolism in the TRACER Trial. CIRCULATION, Vol. 128(22)
- Are There Any Causal Relations Between Growth Differentiation Factor 15 and Outcomes in Patients With Acute Coronary Syndrome? - A Report From the Plato Gwas Study. CIRCULATION, Vol. 128(22)
- Evaluation of the Effect of Interleukin 18 Associated Genetic Polymorphisms on Risk of Cardiovascular Events in Patients With Acute Coronary Syndrome. CIRCULATION, Vol. 128(22)
- Morphine Delays the Onset of Action of Prasugrel in Patients With Prior History of St Elevation Myocardial Infarction. CIRCULATION, Vol. 128(22)
- Impact of Medication on Quantification of Plasma MicroRNAs in Patients With Cardiovascular Disease. CIRCULATION, Vol. 128(22)
- Genetic Polymorphism and Relationship to Cystatin C Concentrations and Outcome - Results From the Platelet Inhibition and Patient Outcomes Study. CIRCULATION, Vol. 128(22)
- Outcomes with ticagrelor versus clopidogrel in relation to high sensitivity troponin-T in non-ST-elevation acute coronary syndrome patients managed with early invasive or non-invasive treatment - a substudy from the prospective randomized PLATelet inhibit. PHARMACOTHERAPY, Vol. 33(10) (pp E189-E189)
- Ischaemic events following planned discontinuation of study treatment with ticagrelor or clopidogrel in the PLATO study. EUROPEAN HEART JOURNAL, Vol. 34 (pp 826-826)
- Difference in causes of death between ticagrelor and clopidogrel in the PLATO trial. EUROPEAN HEART JOURNAL, Vol. 34 (pp 827-827)
- Modulation of complement C3 levels and fibrin clot structure: the role of aspirin dose. EUROPEAN HEART JOURNAL, Vol. 34 (pp 891-891)
- GDF-15 level in acute coronary syndrome and its relations to cardiovascular risk factors, disease manifestations, treatments and outcome - results from the PLATO-study. EUROPEAN HEART JOURNAL, Vol. 34 (pp 733-733)
- Health economic evaluation of ticagrelor compared to generic clopidogrel in patients with acute coronary syndromes intended for non-invasive management based on the PLATO trial. EUROPEAN HEART JOURNAL, Vol. 34 (pp 896-896)
- Hypoglycemia Increases Platelet Reactivity in Patients With Type 2 Diabetes. DIABETES, Vol. 62 (pp A100-A100)
- . Heart, Vol. 99(suppl 2) (pp A7-A7)
- . HEART, Vol. 99
- . Journal of the American College of Cardiology, Vol. 61(10) (pp E1858-E1858)
- . Journal of the American College of Cardiology, Vol. 61(10) (pp E1-E1)
- A study of a preoperative intervention in patients with diabetes undergoing cardiac surgery. DIABETIC MEDICINE, Vol. 30 (pp 152-152)
- ZEBRAFISH AS A MODEL TO INVESTIGATE THE ROLES OF THE P2Y12 RECEPTOR IN VIVO. ATHEROSCLEROSIS, Vol. 225(2) (pp E1-E1)
- Current regional differences in the use of antiplatelet drugs for the treatment of acute coronary syndromes. Results from the EPICOR study. EUROPEAN HEART JOURNAL, Vol. 33 (pp 311-311)
- Vorapaxar in ACS patients undergoing CABG surgery: results from the TRACER trial. EUROPEAN HEART JOURNAL, Vol. 33 (pp 508-509)
- Contemporary pre-hospital management of ACS patients: results from the EPICOR study. EUROPEAN HEART JOURNAL, Vol. 33 (pp 314-314)
- Serial cystatin C measurements and changes in glomerular filtration rate as predictors for death or myocardial infarction in ACS patients. EUROPEAN HEART JOURNAL, Vol. 33 (pp 135-135)
- Availability of cath lab facilities and contemporary inter-hospital transfer patterns for the management of ACS patients: findings from the EPICOR study. EUROPEAN HEART JOURNAL, Vol. 33 (pp 145-145)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E500-E500)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E351-E351)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E504-E504)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E497-E497)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E495-E495)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E629-E629)
- . Journal of the American College of Cardiology, Vol. 59(13) (pp E507-E507)
- . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 59(13) (pp E482-E482)
- . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 59(13) (pp E505-E505)
- Cytochrome P450 2C19 Loss-Of-Function Genetic Variants but not Paraoxonase-1 Activity Modulate P2Y12 Blockade in Response to Clopidogrel Therapy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B45-B45)
- . Journal of the American College of Cardiology, Vol. 57(14) (pp E946-E946)
- . Journal of the American College of Cardiology, Vol. 57(14) (pp E1099-E1099)
- . Journal of the American College of Cardiology, Vol. 57(14) (pp E999-E999)
- Proton Pump Inhibitor Use is Likely a Marker for, Rather than a Cause of, a Higher Risk of Cardiovascular Events: Insights from PLATO. CIRCULATION, Vol. 122(21)
- Relationship between ATP hydrolysis and molecular dynamics in co-freeze-dried sugar-ATP mixtures. JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol. 62(10) (pp 1465-1467)
- Earlier recovery of platelet function after treatment cessation in ticagrelor-treated patients compared to clopidogrel high responders. EUROPEAN HEART JOURNAL, Vol. 31 (pp 389-389)
- Platelet inhibition by ticagrelor is not affected by proton pump inhibitors: results from the PLATO PLATELET substudy. EUROPEAN HEART JOURNAL, Vol. 31 (pp 905-906)
- Ticagrelor versus clopidogrel in patients with acute coronary syndromes and diabetes in the PLATO trial. EUROPEAN HEART JOURNAL, Vol. 31 (pp 202-202)
- Increased incidence of dyspnoea associated with ticagrelor did not appear to adversely affect cardiovascular outcomes in the PLATO study. EUROPEAN HEART JOURNAL, Vol. 31 (pp 203-203)
- Ticagrelor versus clopidogrel in patients with Acute Coronary Syndromes intended for a non-invasive management in the PLATO trial. EUROPEAN HEART JOURNAL, Vol. 31 (pp 203-203)
- The Effect of Ticagrelor on Cardiopulmonary Function in Patients With Stable Coronary Artery Disease. CIRCULATION, Vol. 120(18) (pp S1145-S1145)
- The Effect of Ticagrelor in Stable Coronary Artery Disease Patients Nonresponsive to Clopidogrel: The RESPOND Study. CIRCULATION, Vol. 120(18) (pp S1173-S1173)
- Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Stable Coronary Artery Disease. CIRCULATION, Vol. 120(18) (pp S1102-S1102)
- More Rapid and Consistent Inhibition of Platelet Aggregation is Achieved by Loading With Ticagrelor Compared to Clopidogrel in Patients With Acute Coronary Syndromes: Results From the PLATO PLATELET Substudy. CIRCULATION, Vol. 120(18) (pp S1102-S1102)
- A Randomized Double-Blind Study to Assess the Onset and Offset of the Antiplatelet Effects of Ticagrelor versus Clopidogrel in Patients With Stable Coronary Artery Disease. CIRCULATION, Vol. 120(18) (pp S1143-S1143)
- Maintenance Treatment With Ticagrelor Yields Greater and More Consistent Inhibition of Platelet Function Compared to Clopidogrel in Patients With Acute Coronary Syndromes: Results From the PLATO PLATELET Substudy. CIRCULATION, Vol. 120(18) (pp S1027-S1027)
- PLATO-Invasive: Comparison of Ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes with a planned invasive strategy: Results of the PLATelet inhibition and patient Outcomes (PLATO) trial. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp XVIII-XVIII)
- RIFAMPICIN INCREASES THE EXTENT OF P2Y12 RECEPTOR BLOCKADE ACHIEVED BY CLOPIDOGREL ADMINISTRATION. HEART, Vol. 95 (pp A51-A52)
- High-performance liquid chromatography method development for studying the degradation of freeze-dried adenosine triphosphate when stored at 4 and 40 degrees C. JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol. 61 (pp A130-A130)
- Rifampicin increases the extent of P2Y12 receptor blockade achieved by clopidogrel administration. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 7 (pp 105-105)
- Reversible binding of cangrelor to the P2Y12 receptor prevents the binding of clopidogrel and prasugrel active metabolites. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 7 (pp 942-942)
- . EUROPEAN HEART JOURNAL SUPPLEMENTS, Vol. 10(D) (pp D30-D37)
- The platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp A291-A291)
- . EUROPEAN HEART JOURNAL SUPPLEMENTS, Vol. 10(A) (pp A21-A27)
- Inhibition of platelet aggregation by clopiclogrel is unaffected by the CYP2C19 681G > A polyrnorphism in patients with coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 49(9) (pp 375A-375A)
- AZD6140 exerts greater inhibition of platelet aggregation than clopidogrel in patients with stable atherosclerotic disease or unstable coronary disease. CIRCULATION, Vol. 114(18) (pp 698-699)
- AZD6140, a reversible oral ADP receptor antagonist, does not increase risk of bleeding vs the thienopyridine clopidogrel in patients undergoing CABG surgery in the DISPERSE2 trial. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 98(8A) (pp 204M-204M)
- The G allele of the platelet P2Y1 1622 A > G polymorphism is not associated with platelet hyper-reactivity to ADP in either healthy volunteers or CAD patients. EUROPEAN HEART JOURNAL, Vol. 27 (pp 756-756)
- The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. EUROPEAN HEART JOURNAL, Vol. 27 (pp 753-753)
- The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. HEART, Vol. 92 (pp A111-A111)
- Platelet protease-activated receptor 1 density, trap-induced platelet responses, and the effect of complete P2Y(12) receptor blockade. HEART, Vol. 92 (pp A111-A112)
- The effects of AZD6140, the first oral reversible ADP receptor antagonist, compared with clopidogrel on biochemical markers in patients with acute coronary syndromes (ACS). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 200A-200A)
- Clinical outcomes with AZD6140, an oral reversible ADP receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes (ACS). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 199A-200A)
- Greater inhibition of platelet aggregation be tolerated? - Evaluation of the bleeding risk of AZD6140 compared with clopidogrel (CLOP) in patients with acute coronary syndromes (ACS). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 212A-212A)
- AZD6140 yields greater inhibition of platelet aggregation than clopidogrel in patients with acute coronary syndromes without previous clopidogrel treatment. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 204A-204A)
- AZD6140 yields additional suppression of platelet aggregation in patients with acute coronary syndromes previously treated with clopidogrel. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 204A-204A)
- The DISPERSE2 trial: Safety, tolerability and preliminary efficacy of AZD6140, the first oral reversible ADP receptor antagonist, compared with clopidogrel in patients with non-ST segment elevation acute coronary syndrome. CIRCULATION, Vol. 112(17) (pp U677-U677)
- Common sequence variations in the P2Y12 and CYP3A5 genes do not explain variability in the inhibitory effects of clopidogrel therapy. EUROPEAN HEART JOURNAL, Vol. 26 (pp 486-486)
- Partial P2Y12 receptor blockade by clopidogrel may not be overcome by increasing the clopidogrel dose. EUROPEAN HEART JOURNAL, Vol. 26 (pp 487-487)
- A randomized double blind comparison of two strategies for managing patients on aspirin and clopidogrel therapy requiring urgent coronary revascularization. CIRCULATION, Vol. 110(17) (pp 356-356)
- Gene sequence variations influence platelet reactivity before and during clopidogrel therapy. EUROPEAN HEART JOURNAL, Vol. 25 (pp 237-237)
- Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. HEART, Vol. 90 (pp A31-A31)
- Effects of clopidogrel on platelet calcium mobilisation in acute coronary syndrome patients. EUROPEAN HEART JOURNAL, Vol. 24 (pp 323-323)
- Effect of clopidogrel on procoagulant activity in acute coronary syndromes: Evidence for incomplete P2Y12 receptor blockade. CIRCULATION, Vol. 106(19) (pp 149-150)
- Inhibition of ADP-induced platelet-leukocyte conjugate formation by clopidogrel and AR-C69931MX. EUROPEAN HEART JOURNAL, Vol. 23 (pp 722-722)
- Clinical experience with antithrombotic drugs acting on purine receptor pathways. DRUG DEVELOPMENT RESEARCH, Vol. 52(1-2) (pp 202-212)
Other
Preprints
- Research group
-
PhD Students
- Dr William Parker
- Dr Wael Sumaya
MD Students
- Dr Rachel Orme
- Dr Vatchsala Sree Varadharajan
- Teaching activities
-
I am currently coordinator for the first year medical undergraduate Cardiovascular System module.
- Professional activities and memberships
-
- 2019: Research of the Year award, British Cardiovascular Intervention Society.
- 2017: Member of the BHF Fellowships Committee.
- 2015-2019: Member of the NIHR EME board.
- 2000: DM with distinction, 'Novel platelet antagonists in the management of ischaemic heart disease', University of Nottingham.
- 1999: Young Investigators Award, International Society of Thrombosis and Haemostasis.
Links