Bryant, Helen E, Professor

Professor Helen E Bryant

Clinical Medicine, School of Medicine and Population Health

Professor of Cancer Therapeutics

Head of The DNA replication and repair group

h.bryant@sheffield.ac.uk

GU11, G Floor, The Medical School

Full contact details

Professor Helen E Bryant
Clinical Medicine, School of Medicine and Population Health
GU11, G Floor
The Medical School
Beech Hill Road
91̽��
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

Current PhD Opportunities

Qualifications

1991 - 1995 BSc Medical Biochemistry University of Glasgow

1996 - 1999 PhD MRC Virology Unit, Glasgow

2000 - 2003 Post-doctoral Researcher Ludwig Institute of Cancer Research, St Mary´s Hospital, London.

2003 - 2007 Post-doctoral Researcher YCR Institute for Cancer Studies, University of 91̽��.

2007 - 2012 RCUK Academic Fellow YCR Institute for Cancer Studies, University of 91̽��.

2012 - 2013 Lecturer Department of Oncology, University of 91̽��.

2013 - present Senior Lecturer Department of Oncology and Metabolism, University of 91̽��

Research interests

Dr Bryant has worked in the area of genome biology for 20 years. Her lab employs chemists, biologists and clinicians in order to promote a multi-disciplinary approach to translational research.

By understanding the control of the fidelity of DNA replication in normal cells we aim to understand why defects in the proteins involved are associated with cancer. Her aim is to pinpoint differences between dividing tumour cells and dividing normal cells and determine which are important in cancer development. This has enabled the group to develop drugs which can specifically kill the tumour cells rather than just all dividing cells (personalized therapy).

A separate side to Dr Bryant’s work is the development of novel transition metal-containing photodynamic therapy agents that bind to DNA and induce damage only upon irradiation with specific wavelengths of light. This is a collaboration with Prof. Julia Weinstein in the Department of Chemistry (TUOS).

To this end there are 4 board themes that overlap in the lab.

Understanding of the cellular pathways activated when DNA replication is perturbed.
Improving and understanding radiotherapy response
Identification of the changes in expression of these genes and phenotypic consequences in cancer
Exploitation of these changes in hypothesis-driven drug development.
Chemical development of novel therapeutic agents (focus on PDT agents)

Current projects examine these themes in Bladder, Breast, NSCLC, HNSCC and Neuroblastoma.

Publications

Journal articles

Jones C, Martinez-Alonso M, Gagg H, Kirby L, Weinstein JA & Bryant HE (2024) . J Med Chem.
Jackson CE, Doyle I, Khan H, Williams SF, Aldemir Dikici B, Barajas Ledesma E, Bryant HE, English WR, Green NH & Claeyssens F (2024) . Frontiers in Bioengineering and Biotechnology, 11.
Egerton K, Mitchell TA, Gravells P, Katse R, Fisher M, Muthana M, Eyers CE, Eyers PA & Bryant HE (2023) . ESMO Open, 8(1), 101664-101664.
Saldana-Guerrero IM, Montano-Gutierrez LF, Hafemeister C, Stavish D, Shaw LE, Fetahu IS, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S , Shoeb MR et al (2023) . Cancer Research, 83(7_Supplement), 3542-3542.
King D, Southgate HED, Roetschke S, Gravells P, Fields L, Watson JB, Chen L, Chapman D, Harrison D, Yeomanson D , Curtin NJ et al (2021) . Cancers, 13(24).
Aguilar Cosme JR, Gagui DC, Bryant HE & Claeyssens F (2021) . Frontiers in Molecular Biosciences, 8(11).
Aguilar Cosme JR, Gagui DC, Green NH, Bryant HE & Claeyssens F (2021) . ACS Biomater Sci Eng.
Piberger AL, Bowry A, Kelly RDW, Walker AK, González-Acosta D, Bailey LJ, Doherty AJ, Méndez J, Morris JR, Bryant HE & Petermann E (2020) . Nature Communications, 11(1).
Halliwell JA, Gravells P & Bryant HE (2020) . Current Protocols in Stem Cell Biology, 54(1).
George SL, Lorenzi F, King D, Hartlieb S, Campbell J, Pemberton H, Toprak UH, Barker K, Tall J, da Costa BM , van den Boogaard ML et al (2020) . EBioMedicine, 59.
Harrision D, Gravells P, Thompson R & Bryant HE (2020) . Frontiers in Molecular Biosciences, 7.
King D, Li XD, Almeida GS, Kwok C, Gravells P, Harrison D, Burke S, Hallsworth A, Jamin Y, George S , Robinson SP et al (2020) . Oncotarget, 11(23), 2141-2159.
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) . Oncotarget, 11(13), 1109-1130.
Doherty RE, Bryant HE, Valluru MK, Rennie IG & Sisley K (2019) . Cancers, 11(9).
Aguilar Cosme JR, Bryant HE & Claeyssens F (2019) . PLoS ONE, 14(7).
Willan J, Cleasby AJ, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant HE & Ciani B (2019) . Oncogenesis, 8(5).
Crowston B, Shipp J, Chekulaev DM, McKenzie L, Jones C, Weinstein J, Meijer AJHM, Bryant HE, Natrajan L, Woodward AW & Ward MD (2019) . Dalton Transactions.
Kadhim A, McKenzie LK, Bryant HE & Twyman LJ (2019) . Molecular Pharmaceutics, 16(3), 1132-1139.
Omar SAE, Scattergood PA, McKenzie LK, Jones C, Patmore NJ, Meijer AJHM, Weinstein JA, Rice CR, Bryant HE & Elliott PIP (2018) . Inorganic Chemistry.
McKenzie LK, Bryant HE & Weinstein JA (2018) . Coordination Chemistry Reviews.
Daniels RE, McKenzie LK, Shewring JR, Weinstein JA, Kozhevnikov VN & Bryant HE (2018) . RSC Advances, 8(18), 9670-9676.
Gravells P, Neale J, Grant E, Nathubhai A, Smith KM, James DI & Bryant HE (2018) . DNA Repair, 61, 25-36.
Gravells PL, Grant E, Smith KM, James DI & Bryant HE (2017) . DNA Repair, 52, 81-91.
Mateo J, Boysen G, Barbieri CE, Bryant HE, Castro E, Nelson PS, Olmos D, Pritchard CC, Rubin MA & de Bono JS (2017) . European Urology, 71(3), 417-425.
McKenzie L, Sazanovich I, Baggaley E, Bonneau M, Guerchais V, Williams G, Weinstein J & Bryant HE (2017) . Chemistry - A European Journal, 23(2), 234-238.
McKenzie LK, Sazanovich IV, Baggaley E, Bonneau M, Guerchais V, Williams JAG, Weinstein JA & Bryant HE (2017) . Chemistry - A European Journal, 23(2), 234-234.
Ali R, Rakha EA, Madhusudan S & Bryant HE (2016) . Pathology.
Omar SA, Scattergood PA, McKenzie LK, Bryant HE, Weinstein JA & Elliott PI (2016) . Molecules, 21(10).
Patterson K, Arya L, Bottomley S, Morgan S, Cox A, Catto J & Bryant HE (2016) . Oncotarget.
Bryant HE (2016) . European Urology, 69(6), 996-997.
Jana A, Crowston BJ, Shewring JR, McKenzie LK, Bryant HE, Botchway SW, Ward AD, Amoroso AJ, Baggaley E & Ward MD (2016) . Inorganic Chemistry, 55(11), 5623-5633.
Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA & Bryant HE (2016) . Scientific Reports, 6.
Arora A, Abdel-Fatah TMA, Agarwal D, Doherty R, Croteau DL, Moseley PM, Hameed K, Green A, Aleskandarany MA, Rakha EA , Patterson K et al (2016) . Carcinogenesis, 37(1), 63-71.
Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA & Bryant HE (2015) . Photodiagnosis and Photodynamic Therapy, 12(3), 338-339.
Pang KH, Miah S, Drayton RM, Rehman I, Clarke R, Stoehr R, Hartmann A, Lavin M, Bryant HE, Martens-Uzunova ES , Jenster G et al (2015) . European Urology Supplements, 14(2), e426-e426b.
King D, Yeomanson D & Bryant HE (2015) . Journal of Pediatric Hematology/Oncology, 37(4), 245-251.
Drayton RM, Rehman I, Clarke R, Zhao Z, Pang K, Miah S, Stoehr R, Hartmann A, Blizard S, Lavin M , Bryant HE et al (2015) . Cancer Epidemiology Biomarkers & Prevention, 24(1), 268-275.
Lafta IJ, Bryant HE & Goldman ASH (2014) . Oncotarget, 5(18), 7984-7985.
Drayton RM, Peter S, Myers K, Miah S, Dudziec E, Bryant HE & Catto JWF (2014) . Oncotarget, 5(15), 6375-6386.
Drayton RM, Dudziec E, Peter S, Bertz S, Hartmann A, Bryant HE & Catto JW (2014) . Clin Cancer Res, 20(7), 1990-2000.
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE , Bundred NJ et al (2013) . Breast Cancer Research(5), R92.
Gravells P, Hoh L, Solovieva S, Patil A, Dudziec E, Rennie IG, Sisley K & Bryant HE (2013) . Oncogene, 32(46), 5338-5346.
Loseva O, Jemth A-S, Bryant HE, Schüler H, Lehtiö L, Karlberg T & Helleday T (2012) . Journal of Biological Chemistry, 287(41), 34494-34494.
Fathers C, Drayton RM, Solovieva S & Bryant HE (2012) . Cell Cycle, 11(5), 990-997.
Drayton RM, Dudziec E, Catto JWF & Bryant HE (2012) . Cancer Research, 72(2 Supplement), A10-A10.
Bryant HE (2012) . Methods Mol Biol, 920, 315-321.
Gravells P, Hoh L, Canovas D, Rennie IG, Sisley K & Bryant HE (2011) . Br J Cancer, 104(7), 1098-1105.
Hoh L, Gravells P, Canovas D, Ul-Hassan A, Rennie IG, Bryant H & Sisley K (2011) . Genes Chromosomes Cancer, 50(1), 34-42.
Blundred R, Myers K, Helleday T, Goldman ASH & Bryant HE (2010) . DNA Repair (Amst), 9(9), 964-975.
Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA & Helleday T (2010) . Cancer Res, 70(13), 5389-5398.
Loseva O, Jemth AS, Bryant HE, Schuler H, Lehtio L, Karlberg T & Helleday T (2010) . J BIOL CHEM, 285(11), 8054-8060.
McLachlan J, Fernandez S, Helleday T & Bryant HE (2009) . DNA Repair (Amst), 8(12), 1424-1433.
Catto JWF, Miah S, Owen HC, Bryant H, Myers K, Dudziec E, Larré S, Milo M, Rehman I, Rosario DJ , Di Martino E et al (2009) . Cancer Res, 69(21), 8472-8481.
Al-Minawi AZ, Lee Y-F, Håkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M , Hinz JM et al (2009) . Nucleic Acids Res, 37(19), 6400-6413.
Bryant HE, Petermann E, Schultz N, Jemth A-S, Loseva O, Issaeva N, Johansson F, Fernandez S, McGlynn P & Helleday T (2009) . EMBO J, 28(17), 2601-2615.
Ying S, Myers K, Bottomley S, Helleday T & Bryant HE (2009) . Nucleic Acids Res, 37(15), 5105-5113.
Bryant H (2007) A function for PARP at stalled replication forks. MUTAGENESIS, 22(6), 431-431.
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ & Helleday T (2007) . Nature, 447(7142), 346-346.
Bryant HE, Ying S & Helleday T (2006) . Mutat Res, 599(1-2), 116-123.
Bryant HE & Helleday T (2006) . Nucleic Acids Res, 34(6), 1685-1691.
Helleday T, Bryant HE & Schultz N (2005) . Cell Cycle, 4(9), 1176-1178.
Saleh-Gohari N, Bryant HE, Schultz N, Parker KM, Cassel TN & Helleday T (2005) . Mol Cell Biol, 25(16), 7158-7169.
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ & Helleday T (2005) . Nature, 434(7035), 913-917.
Amon W, Binné UK, Bryant H, Jenkins PJ, Karstegl CE & Farrell PJ (2004) . J Virol, 78(24), 13460-13469.
Bryant HE & Helleday T (2004) . Biochem Soc Trans, 32(Pt 6), 959-961.
Bryant H & Farrell PJ (2002) . J Virol, 76(20), 10290-10298.
Bryant HE, Wadd SE, Lamond AI, Silverstein SJ & Clements JB (2001) . J Virol, 75(9), 4376-4385.
Bryant HE, Matthews DA, Wadd S, Scott JE, Kean J, Graham S, Russell WC & Clements JB (2000) . J Virol, 74(23), 11322-11328.
Wadd S, Bryant H, Filhol O, Scott JE, Hsieh TY, Everett RD & Clements JB (1999) . J Biol Chem, 274(41), 28991-28998.
Saldana-Guerrero IM, Montano-Gutierrez LF, Boswell K, Hafemeister C, Poon E, Shaw LE, Stavish D, Lea RA, Wernig-Zorc S, Bozsaky E , Fetahu IS et al () . Nature Communications, 15(1).
Fabbrizi MR, Nickson CM, Hughes JR, Robinson EA, Vaidya K, Rubbi CP, Kacperek A, Bryant HE, Helleday T & Parsons JL () . Cell Death & Disease, 15(2).
Martínez-Alonso M, Jones CG, Shipp JD, Chekulaev D, Bryant HE & Weinstein JA () . JBIC Journal of Biological Inorganic Chemistry.
Taher Z, Legge C, Winder N, Lysyganicz P, Rawlings A, Bryant H, Muthana M & Staniland S () . Pharmaceutics, 13(3), 367-367.

Chapters

Shewring JR, Hodgson L, Bryant HL, Bullough PA, Weinstein JA & Verkade P (2021) , Methods in Cell Biology (pp. 69-87). Elsevier
Bryant HE & Shall S (2015) , Cancer Drug Discovery and Development (pp. 315-344). Springer International Publishing

Conference proceedings papers

Jackson CE, Green N, English W, Bryant HE & Claeyssens F (2023) Production of porous polycaprolactone polyHIPEs as substrates for in vitro 3D breast cancer cell culture. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Jackson CE, Green N, English W, Bryant HE & Claeyssens F (2023) Production of porous polycaprolactone polyHIPEs as substrates for in vitro 3D breast cancer cell culture. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Mitchell T, Jones T, Danson S, Glover M, Bury J, Horsman J, Christian L, Hill E, Harrison E, Hatton M & Bryant H (2021) Investigation of Aurora Kinase A as a Potential Biomarker of Radiation in Non-Small Cell Lung Cancer (NSCLC). JOURNAL OF THORACIC ONCOLOGY, Vol. 16(10) (pp S1163-S1164)
Mitchell T, Astley J, Robinson S, Bryant H, Danson S, Tahir B & Hatton M (2021) Artificial Neural Network-Based Tumour Recurrence Prediction in Non-Small Cell Lung Cancer Patients Following Radical Radiotherapy. JOURNAL OF THORACIC ONCOLOGY, Vol. 16(10) (pp S958-S958)
Bradbury A, King D, Bryant H, Zenke F, Drew Y & Curtin N (2018) Investigating the effect of replication stress and other phenotypic factors as determinants of sensitivity to single agent ATR inhibitor, VE-821 in ovarian cancer cell lines. EUROPEAN JOURNAL OF CANCER, Vol. 103 (pp E32-E32)
Ritchie J, Wyld L & Bryant HE (2013) UPR Activation via glucose deprivation and depletion of GRP78 protein (using siRNA) do not alter radiosensitivity in the human breast cancer cell line MCF7. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S425-S425)
Ślusarczyk A, Bryant HE, Chen E, Hitchcock I, Zeidler M, Chantry A & Thomas S () . The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, Vol. 129 (pp 17-17)

Preprints

Gamill MC, Holmes EP, Provan JI, Wiggins L, Rusková R, Whittle S, Catley TE, Main KHS, Shephard N, Bryant HE , Račko D et al (2024) , Cold Spring Harbor Laboratory.
Saldana-Guerrero IM, Montano-Gutierrez LF, Hafemeister C, Stavish D, Shaw LE, Fetahu IS, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S , Shoeb MR et al (2022) , Cold Spring Harbor Laboratory.
Piberger AL, Bowry A, Kelly RDW, Walker AK, Gonzalez D, Bailey LJ, Doherty AJ, Méndez J, Morris JR, Bryant HE & Petermann E () , Cold Spring Harbor Laboratory.
Kim HR, Santhakumar K, Markham E, Baldera D, Bryant HE, El-Khamisy SF & van Eeden FJ () , Cold Spring Harbor Laboratory.
Willan J, Cleasby A, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant H & Ciani B () , Cold Spring Harbor Laboratory.

Research group

Polly Gravells - Postdoctoral Research (Biologist)
David King - Clinical Lecturer
Saskia Roetschke - Clinical Research Fellow
Marta Martinez - Postdoctoral Researcher (Chemist)
Emma Grant - Postgraduate Student
Callum Jones - Postgraduate Student
Chris Legge - Postgraduate Student
Thomas Jones - Postgraduate Student
Fatma Bucklain - Postgraduate Student
Hannah Gagg - Technician

Teaching interests

2012 - Postgraduate certificate in Learning and Teaching

Fellow of the Higher Education Academy

MSc - Translational Oncology

MSc - Molecular Medicine

Undergraduate - Genome Stability & Genetic Change module