Professor Craig Murdoch
BSc (Hons), PhD
School of Clinical Dentistry
Professor in Oral Bioscience
+44 114 215 9367
Full contact details
School of Clinical Dentistry
19 Claremont Crescent
91探花
S10 2TA
- Profile
-
After graduating with a BSc dual honours in Biochemistry/Microbiology I gained a PhD at the Institute of Child Health, University of 91探花 investigating the role of chemokine receptors on endothelial and epithelial cells within the research group of Prof Adam Finn. Following a brief spell researching the pathogenesis of pneumococcal pneumonia, I spent five years working as a post-doctoral researcher in Prof Claire Lewis鈥檚 group on tumour-associated macrophages in the Department of Oncology at the University of 91探花 Medical School.
I was appointed Lecturer at the School of Clinical Dentistry in 2006, Senior Lecturer in 2012, Reader in 2015 and then to Personal Chair in 2019 where my research encompasses understanding the molecular mechanism of oral disease.
- Research interests
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My main interests are centred on oral epithelial biology and the molecular mechanisms of oral diseases and their systemic sequalae. I am particularly interested in how immune cells are recruited to diseased oral sites and how they interact with other cells/microbes within the local microenvironment. As part of this research my group has developed novel tissue engineered in vitro models of both healthy and diseased oral mucosa to investigate pathogenic mechanisms. I have a long-standing track record of developing and utilising in vitro 3D tissue constructs and zebrafish larvae as direct replacements for animal models and have used these experimental models to study the role of oral microorganisms in mucosal and systemic disease. I am also involved with projects aimed at developing novel oral patches for mucosal drug delivery (with AFYX Therapeutics) and how mathematical modelling of oral tissue can aid the development of drug delivery systems (with University of Liverpool) and non-invasive diagnostics for the detection and management of oral pre-malignant lesions (with Zilico).
Current projects include:
- Role of innate immune cells in head and neck cancer.
- Development of tissue engineered immunocompetent oral mucosal and skin models.
- Host-pathogen interactions at the mucosal surface.
- Use of zebrafish to examine the role of oral microbes in systemic disease.
- Novel forms of oral mucosal drug delivery and the role of xenobiotic metabolising enzymes in the oral mucosa.
Research group
- Amy Harding (PDRA): Development and validation of tissue-engineered skin equivalents to detect skin irritation. (Rohto Pharmaceutical Company Limited) with Dr Helen Colley & Dr Simon Danby.
- Bethany Ollington: Use of immune-competent tissue engineered oral mucosal equivalents to model oral infection. (with Dr Helen Colley, MRC DiMeN Studentship)
- Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (with Dr Helen Colley & Dr Simon Danby, Almirall S.A.-funded PhD Studentship)
- Asma El-Howati: Development of tissue engineered oral inflammatory lesions (with Dr Helen Colley, Funded by Libyan Government Scholarship)
- Antonia Cutts: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (with Prof Graham Stafford, University Faculty Studentship)
- Klaudia Slowik: The role of xenobiotic metabolising enzymes in drug delivery for prevention of alveolar osteitis. (with Dr Helen Colley, EPSRC-Funded Studentship)
- Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (with Dr Helen Colley, Dr Seb Spain and Prof Paul Hatton, EPSRC Centre for Doctoral Training in Polymers and Soft Matter/ AFYX Therapeutics studentship)
- Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (with Prof Paul Hatton - Funded by Kuwait Government Scholarship)
- Publications
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Journal articles
- . International Journal of Pharmaceutics, 124827-124827.
- . J Control Release.
- . Journal of Investigative Dermatology.
- . Biomaterials Advances, 157.
- . Biomedical Materials & Devices.
- . Journal of Controlled Release, 350, 146-157.
- . Sensors, 22(15).
- . Journal of Periodontology.
- . Frontiers in Oral Health, 2.
- . Tissue Engineering Part C: Methods.
- . PLoS ONE, 16(7).
- . JID Innovations, 1(2), 100011-100011.
- . Journal of Dental Research, 100(5), 479-486.
- . The FEBS Journal, 288(5), 1479-1495.
- . European Journal of Oral Sciences.
- . Frontiers in Oral Health, 2.
- . Journal of Dental Research, 99(13), 1494-1501.
- . Biomaterial Investigations in Dentistry, 7(1), 146-157.
- . Materials Science and Engineering: C, 112.
- . Pharmaceutics, 12(6).
- . ACS Biomaterials Science & Engineering.
- . European Journal of Pharmaceutical Sciences.
- . Interface Focus, 10(2).
- . Cancer Cytopathology, 128(3), 207-220.
- . Beilstein Journal of Nanotechnology, 10, 2304-2328.
- . Computational Toxicology, 12.
- . Journal of Investigative and Clinical Dentistry, 10(4).
- . Current Protocols in Toxicology, 81(1).
- . Infection and Immunity.
- . The Journal of Infectious Diseases.
- . BIOMEDICINE, 112.
- . Cellular and molecular biology.
- . Toxicology in Vitro, 55, 160-172.
- . International Journal of Cancer, 144(2), 334-344.
- . Biomaterials, 178, 134-146.
- . BMJ Open, 8(8).
- . iScience, 4, 84-96.
- . Experimental Dermatology, 27(5), 473-475.
- . European Journal of Nutrition, 57(4), 1321-1332.
- . Toxicology in Vitro, 48, 262-275.
- . Journal of Tissue Engineering and Regenerative Medicine, 12(3), e1636-e1646.
- . Journal of Oral Pathology and Medicine.
- . Carcinogenesis, 39(2), 170-179.
- . Journal of Medical Microbiology.
- . Computational Toxicology, 3, 44-57.
- . ACS Applied Materials and Interfaces, 9(13), 11557-11567.
- . MicrobiologyOpen, 6(1).
- . Tissue Engineering Part C: Methods, 22(2), 1108-1117.
- . Scientific Reports, 6, 36023-36023.
- . Oral Oncology, 60, 103-111.
- . European Journal of Cancer, 61, S60-S60.
- . Toxicology Research, 5, 1053-1065.
- . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 120(4), 474-482.e2.
- . Nature Communications, 6.
- . Sovremennye tehnologii v medicine, 7(1), 60-68.
- . International Journal of Nanomedicine, 9, 4521-4532.
- . Mol Pharm, 11(4), 1176-1188.
- . Microbes Infect, 16(4), 310-319.
- . Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 339-348.
- . Hypoxia, 2, 185-196.
- . FASEB J, 27(11), 4455-4465.
- . Mol Oral Microbiol, 28(5), 366-378.
- . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(3), e201-e201.
- . Int J Radiat Biol, 89(11), 907-914.
- . J Biol Chem, 288(30), 22006-22018.
- . Semin Cancer Biol, 23(3), 149-158.
- . Journal of Mathematical Biology, 69(4), 839-873.
- . J Oral Pathol Med, 42(4), 309-314.
- . Egyptian Journal of Pathology, 32(2), 217-226.
- . J Dent Res, 91(7), 642-650.
- . J Biomed Opt, 16(11), 116015.
- . Microbiology, 157(Pt 6), 1806-1815.
- . J Immunol, 186(7), 4183-4190.
- . Int J Cancer, 129(4), 847-858.
- . Cancer Res, 71(5), 1805-1815.
- . Journal of Ethnopharmacology, 138(3), 780-787.
- . British Journal of Cancer, 105(10), 1582-1592.
- . Microbial Pathogenesis, 50(6), 278-285.
- . Microbes and Infection, 13(1), 65-75.
- . Nanomedicine (Lond), 5(7), 1025-1036.
- . Eukaryot Cell, 9(9), 1363-1373.
- . Cancer Res, 70(13), 5270-5280.
- . J Pathol, 221(2), 153-163.
- . Infect Immun, 77(9), 3872-3878.
- . Blood, 114(4), 844-859.
- . Pharm Res, 26(7), 1718-1728.
- . Int J Exp Pathol, 90(3), 222-231.
- . Infect Immun, 76(10), 4370-4377.
- . Nat Rev Cancer, 8(8), 618-631.
- . CANCER LETT, 265(2), 239-249.
- . Gene Ther, 15(12), 902-910.
- . Neoplasia, 10(4), 329-339.
- . Immunobiology, 213(9-10), 899-908.
- . TRENDS IMMUNOL, 28(12), 519-524.
- . B MATH BIOL, 69(5), 1747-1776.
- Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J.Immunol., 178(11), 7405-7411.
- . PEDIATR INFECT DIS J, 26(3), 243-246.
- . PEDIATR INFECT DIS J, 25(1), 80-81.
- . Int J Cancer, 117(5), 701-708.
- . J Immunol, 175(10), 6257-6263.
- . Am J Pathol, 167(3), 627-635.
- . Blood, 104(8), 2224-2234.
- . Pediatr Infect Dis J, 23(4), 307-313.
- . Arch Dis Child, 88(3), 211-214.
- . J Infect Dis, 186(9), 1253-1260.
- . Urol Res, 29(2), 102-107.
- . Immunol Rev, 177, 175-184.
- Chemokine receptors and their role in inflammation and infectious diseases.. Blood, 95(10), 3032-3043.
- . Blood, 95(10), 3032-3043.
- . J Vasc Res, 37(1), 1-7.
- . Immunology, 98(1), 36-41.
- . Cytokine, 11(9), 704-712.
- Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials. CLIN EXP METASTAS, 17(5), 389-396.
- . Immunology Letters, 56, 101-101.
- . Oral Diseases.
- . Molecular Pharmaceutics.
- . PLOS ONE, 10(4), e0122285-e0122285.
Chapters
- , Biomaterials for Oral and Dental Tissue Engineering (pp. 245-255). Elsevier
- , Biomaterials for Oral and Dental Tissue Engineering (pp. xiii-xvii). Elsevier
- (pp. 38-57).
Conference proceedings papers
- . European Urology, Vol. 83 (pp S1190-S1190)
- ELECTROSPUN PATCH DELIVERY OF ANTI-TNF. F(AB) ANTIBODY FRAGMENT FOR THE TREATMENT OF ORAL MUCOSAL INFLAMMATORY DISEASES. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 360-360)
- ELECTROSPUN ORAL PATCHES FOR PAIN RELIEF OF DRY SOCKET. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 1530-1530)
- AN IN VITRO IMMUNOCOMPETENT HUMAN TISSUE-ENGINEERED MODEL OF ATOPIC DERMATITIS FOR DRUG TESTING. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 492-492)
- Development of an in vitro immunocompetent human skin-equivalent model. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E29-E29)
- Development and validation of tissue-engineered human skin equivalents to detect stinging potential. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E31-E31)
- . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 126(4) (pp e204-e204)
- Vaginal epithelial cells co-cultured with Lactobacillus and anaerobes differentially express acetate and CXCL8. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 125 (pp 90-90)
- . APPLIED IN VITRO TOXICOLOGY, Vol. 4(1), 23 November 2017 - 24 November 2017.
- Cervicovaginal Epithelial Cells Differentially Express Acetate and CXCL8 in Co-Culture with Preterm Birth-Associated Bacteria and Protective Lactobacillus Species.. REPRODUCTIVE SCIENCES, Vol. 25 (pp 187A-187A)
- Mathematical modelling predicts the spatial distribution of metabolism in skin. European Cells and Materials, Vol. 32 (pp 96-96)
- . Oral Diseases((Suppl. 2)) (pp 10-13), 15 September 2016 - 17 September 2016.
- . Oral Diseases, Vol. 22(S2) (pp 11-11), 15 September 2016 - 17 September 2016.
- . Oral Diseases, Vol. 22(S2) (pp 10-11), 15 September 2016 - 17 September 2016.
- . Oral Diseases, Vol. 22 (pp 10-10)
- . Oral Diseases, Vol. 22(S2) (pp 19-19), 15 September 2016 - 17 September 2016.
- Isolation and immortalisation of tonsillar keratinocytes for three-dimensional tissue engineered tonsil mucosal models. European Cells and Materials, Vol. 31(Suppl 1) (pp 20-20), 28 June 2016 - 1 July 2016.
- . Photonic Therapeutics and Diagnostics XII, 13 February 2016 - 18 February 2016.
- The Effect of Relaxin-2 and Tissue Inhibitors of Matrix Metalloproteinase-2 (TIMP-2) on the Expression Levels of Matrix Metalloproteinase-2 (MMP-2) by Co-Incubation of Endometrial Stromal and Trophoblast Cell Lines.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 335A-335A)
- . Toxicology Letters, Vol. 238(2) (pp S176-S176)
- Using 3-D Models To Investigate Trophoblast-Endometrial Interactions In Vitro. REPRODUCTIVE SCIENCES, Vol. 22 (pp 226A-226A)
- . Tumor Biology
- The role of HOX genes in Head and Neck Squamous Cell Carcinoma (HNSCC). VIRCHOWS ARCHIV, Vol. 463(2) (pp 177-177)
- The role of miR-196a and HOXB9 in head and neck squamous cell carcinoma. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S121-S121)
- Sialyl Lewis A and sialyl Lewis X antigens mediate oral cancer cell binding to recombinant E-selectin and TNF-alpha-stimulated endothelial cells. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S134-S134)
- Tissue engineered models of oral disease for the study of a novel drug delivery system. ORAL DISEASES, Vol. 18
- CXCL12/CXCR4 axis mediates recruitment of monocytes to oral cancer spheroids. ORAL DISEASES, Vol. 18 (pp 8-8)
- Non-invasive lab-on-a-chip characterization of potentially malignant oral disorders. ORAL DISEASES, Vol. 18 (pp 4-4)
- . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S254-S254)
- . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S287-S287)
- Using zebrafish as an in vivo model to study Candida albicans-mediated systemic candidiasis. MYCOSES, Vol. 55 (pp 11-11)
- Development of a static adhesion assay to identify host proteins exploited by Candida albicans. MYCOSES, Vol. 55 (pp 303-303)
- . Molecular and Cellular Biology
- . DRUG DISCOVERY TODAY, Vol. 15(23-24) (pp 1097-1098)
- Using polymersomes to deliver chemotherapeutic agents to oral cancer cells. ORAL DIS, Vol. 16(6) (pp 527-527)
- Atherosclerosis and oral health: mechanisms for P.gingivalis survival in endothelial-cells. Oral Diseases, Vol. 16 (pp 516-516)
- In vitro modelling of oral and vaginal candidiasis host-pathogen interactions. ORAL DIS, Vol. 16(6) (pp 517-517)
- Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies. ORAL DIS, Vol. 16(6) (pp 518-518)
- Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing sustained hypoxia. EJC SUPPLEMENTS, Vol. 8(5) (pp 77-77)
- Engineering Macrophages to Synthesize Recombinant Adenoviruses in Hypoxic Areas of Human Prostate Tumours. HUMAN GENE THERAPY, Vol. 21(4) (pp 488-488)
- . Proceedings of the IASTED International Conference on Nanotechnology and Applications, NANA 2010 (pp 559-564)
- . ORAL ONCOLOGY (pp 68-68)
- . ORAL ONCOLOGY (pp 160-160)
- . ORAL ONCOLOGY (pp 66-66)
- Imaging of polymersome penetration into 3D tissue engineered models of oral mucosa and head and neck cancer. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 58)
- Magnetite nanoparticle-loaded macrophages enhance gene delivery to tumours. IMMUNOLOGY, Vol. 120 (pp 82-82)
- Microenvironmental signals regulating the tumour-promoting functions of macrophages: role of hypoxia and necrotic debris. JOURNAL OF LEUKOCYTE BIOLOGY (pp 56-56)
- Radiation, hypoxia and chemotherapy-mediated gene therapy and the potential for tumour delivery via macrophages. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 63(2) (pp S137-S137)
- Effect of hepatavalent conjugate pneumococcal vaccine in infancy and booster polysaccharide vaccine at 13 months on nasopharyngeal carriage of S-pneumoniae in children aged 2 to 4 years. CLIN INFECT DIS, Vol. 33(7) (pp 1148-1148)
- CXC chemokine receptor expression on human endothelial cells. J VASC RES, Vol. 35(5) (pp 388-388)
- Leukocyte chemoattractant receptor expression on endothelial and epithelial cells. IMMUNOLOGY, Vol. 89 (pp OM115-OM115)
- Analysis of the endothelial panel reactivity against the type II alveolar epithelial cell line, A549.. TISSUE ANTIGENS, Vol. 48(4-II) (pp EC216-EC216)
- Research group
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PhD students:
- Cher Farrugia: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (co-supervisor: Dr Graham Stafford, University Faculty Studentship)
- Bethany Ollington: Immune-competent tissue engineered oral mucosal models to investigate xenobiotic metabolism. (co-supervisor: Dr Helen Colley, DiMeN MRC Studentship)
- Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (co-supervisors: Dr Helen Colley & Dr Simon Danby, Almirall S.A. funded PhD Studentship)
- Asma El-Howati: Tissue engineered oral inflammatory lesions (lead supervisor: Dr Helen Colley, Funded by Libyan Government Scholarship)
- Klaudia Slowik: The role of metabolising enzymes in drug delivery for prevention of alveolar osteitis. (lead supervisor: Dr Helen Colley, EPSRC Funded Studentship)
- Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (lead supervisor: Dr Helen Colley, EPSRC Centre for Doctoral Training in Polymers and Soft Matter)
- Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (lead supervisor: Prof. Paul Hatton - Funded by Kuwait Government Scholarship)
- Teaching activities
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Undergraduate:
Bachelor of Dental Surgery:
- DEN11001 - The Human Body
- DEN11002 - The Oral Cavity in Health and Disease
- DEN21004 鈥 Nutrition, Disease and Materials
- DEN31002 - Integrated Human Disease
- DEN41004 - Oral Disease
BSc Bio-Dental Science and Technology:
MbChB Medicine:
- MEDU01 鈥 Immunology
Post-Graduate Taught:
- DEN616 鈥 Tissue Engineering & Regenerative Dentistry (module lead) taught to both MSc in Dental Materials Science and MMedSci in Diagnostic Oral Pathology
- OCP604 鈥 MSc(Res) Translational Oncology (Chemokines in Cancer)
- PGT research projects regularly supervised for MSc Dental Materials Science, MMedSci in Diagnostic Oral Pathology, MSc Molecular Medicine and MSc(Res) Translational Oncology.
- Professional activities and memberships
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- British Association for Cancer Research National Executive Committee Member (2017 - 2021).
- National Centre for the Replacement Refinement and Reduction of Animals (NC3R) Studentship Grant Review Board Member (2015 - 2020).
- PlosOne Academic Editor.
- Associate Editor Frontiers in Oral Health
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