Professor Jagroop Pandhal
BSc (Hons), MSc (Hons), PhD
School of Chemical, Materials and Biological Engineering
School of Chemical, Materials and Biological Engineering
Professor of Microbial Systems Engineering
Engineering Graduate School Deputy Head of Admissions
+44 114 222 4914
Full contact details
School of Chemical, Materials and Biological Engineering
Room D61
Sir Robert Hadfield Building
Mappin Street
91̽»¨
S1 3JD
- Profile
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I am a biological engineer with a passion for exploiting the diverse functional capabilities of microbes to answer emerging societal challenges. We are largely focussed on metabolic engineering of microbial systems for making all sorts of products from high to medium/low value, including therapeutic proteins and polyols for bio-plastics. We also use microbes for bioremediation and resource recovery, including converting complex industrial waste streams into microbial feedstocks. More recently we have become fascinated with the concept of creating synthetic microbial communities to face some of the more complex challenges. We apply a variety of tools to uncover interactions and metabolic functions, with quantitative proteomics being one of our favourite tools.
My undergraduate was in Microbiology in the Department of Molecular Biology and Biotechnology at 91̽»¨. I then spent time doing research in Chicago, USA followed a year of research in applied aspects of biosciences in Nottingham. However, I returned to 91̽»¨ for my doctoral studies and worked at the interface of life sciences and engineering, developing quantitative proteomics tools to complement environment-focused projects with functional characterisation. After a successful PDRA funded by the Bioprocess Research Industry Club I was awarded an Independent Fellowship from NERC. Since 2015, I have led my own research team as an academic in the Department of Chemical and Biological Engineering (CBE). I have spent quite some time in 91̽»¨ now, and consequently I have made an excellent base to work with academics across all faculties, and have some brilliant friends to share ideas and write grants with. However, our international portfolio of collaborators is also very strong.
I am particularly proud of my research group, and so far, have been lucky to supervise an incredibly international team of PhD students and PDRA’s with representatives from Portugal, Italy, India, Cameroon, Iraq, UK, Kuwait, Nigeria, Malaysia, China, Brazil, Peru, Egypt and Mexico.
- Research interests
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My research aims to exploit microbial systems for biomanufacturing through to bioremediation. We engineer cells, but also apply advanced omics technologies to better understand how microbial communities in the natural environment function, with a view to creating synthetic microbial consortia for industrial processes.
Key research interests:
- Metabolic engineering
- Quantitative proteomics (metaproteomics and glycosylation)
- Synthetic microbial communities
- Algae Biotechnology
- Biomanufacturing
It is widely recognised that the fundamental training of a biologist and an engineer is different. Mathematical theories and quantitative methods are at the forefront of engineering approaches, and therefore their application to complex systems, including biological, is a useful attribute.
However, biologists have the advantage of formulating better testable hypotheses, experimental designs and data interpretation from these complex biological systems. This is namely due to different techniques and strategies used by life scientists to qualitatively decipher complex systems.
The skills of an engineer and life scientist are therefore complementary. I work at this interface to reveal (hopefully useful) information about complex biological systems.
- Publications
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Journal articles
- . New Biotechnology, S1871-6784(24)00531.
- . Journal of Proteome Research, 23(3), 999-1013.
- . Front Microbiol, 15, 1349016.
- . Bioresource Technology Reports, 24, 101682-101682.
- . Biotechnology for Biofuels and Bioproducts, 16.
- . Phycology, 2(3), 297-318.
- . New Biotechnology, 68, 9-18.
- . Frontiers in Bioengineering and Biotechnology, 10, 838445.
- . Microbiology, 167(12).
- . Journal of Biotechnology.
- . Biotechnology for Biofuels, 14(1).
- . Bioresource Technology, 321.
- . Environmental Science: Water Research & Technology.
- . Bioresource Technology, 319.
- . Frontiers in Microbiology, 11.
- . Biology, 8(4).
- . BioEngineering, 6(1).
- . Geoderma, 334, 113-123.
- , 145-155.
- . Metabolites, 8(4).
- . Frontiers in Microbiology, 9.
- . Biology, 7(1), 4-4.
- . AIMS Bioengineering, 5(1), 1-38.
- . New Phytologist, 217(2), 599-612.
- . AMB Express, 7.
- . Biochemical and Biophysical Research Communications.
- . Methods in molecular biology (Clifton, N.J.), 233-250.
- . Biotechnology Letters.
- . Biotechnol Lett.
- . Frontiers in Microbiology, 7, 1172-1172.
- . Biotechnology Journal, 11(8), 1014-1024.
- , 17-35.
- . Current Opinion in Biotechnology, 30, 205-210.
- . Biochem J, 458(3), 499-511.
- . Biotechnol Lett, 36(6), 1141-1151.
- Monitoring earths's canary. Planet Earth(WINTER), 22-24.
- . Pharmaceutical Bioprocessing, 1(3), 221-224.
- . Biotechnol Bioeng, 110(9), 2482-2493.
- . Metab Eng, 15, 124-133.
- . J Proteome Res, 11(12), 5959-5971.
- . Anal Bioanal Chem, 404(4), 1011-1027.
- . Biochem Biophys Res Commun, 419(3), 472-476.
- . Current Proteomics, 8(1), 17-30.
- . Biotechnol Bioeng, 108(4), 902-912.
- . Biotechnol Lett, 32(9), 1189-1198.
- . Curr Opin Microbiol, 13(3), 301-306.
- . Current Opinion in Microbiology, 13(3), 301-306.
- . J Proteome Res, 8(2), 818-828.
- . Saline Systems, 5, 8.
- . CONSERV GENET, 9(3), 751-756.
- . Proteomics, 8(11), 2266-2284.
- . Saline Systems, 4, 1.
- . MOL ECOL NOTES, 7(4), 711-715.
- . J Proteome Res, 6(3), 996-1005.
- . Mol Ecol, 15(5), 1299-1320.
- . MOL ECOL NOTES, 5(2), 289-297.
- . MOL ECOL NOTES, 3(2), 270-273.
- . Molecular Biotechnology.
- . Communications Biology, 7(1).
- . mSystems.
- . Molecular Ecology Notes, 0(0), 070621074211164-???.
- .
- . Biology, 7(1).
- Direct Measurements of CO2 Capture are Essential to Assess the Technical and Economic Potential of Algal-CCUS. Journal of Co2 Utilization.
Chapters
- , Computer Aided Chemical Engineering (pp. 2649-2654). Elsevier
- , Quantitative Proteomics (pp. 49-79). Royal Society of Chemistry
- Making Sense Out of the Proteome: the Utility of iTRAQ and TMT, QUANTITATIVE PROTEOMICS (pp. 51-79).
Conference proceedings papers
- . Advanced Science Letters, Vol. 24(12) (pp 9502-9504)
- . Fourth International Conference on Advances in Bio-Informatics, Bio-Technology and Environmental Engineering - ABBE 2016
- . USES Conference Proceedings
Preprints
- , Research Square Platform LLC.
- , Research Square Platform LLC.
- , Cold Spring Harbor Laboratory.
- . New Biotechnology, S1871-6784(24)00531.
- Teaching activities
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I teach fundamental and applied concepts in biotechnology to first year students through to more complex unit operations involved in environmental engineering to MEng and MSc students. This covers about 350 students.
- Professional activities and memberships
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- Committee member of Microbiology
- Society Associate member of iChemE
- Metaproteomics Initiative
- UKRI Peer review college
- AlgaeUK
Links